ライフサイエンスコーパス: iron

1 o (SNR) especially in the presence of severe iron.

2 central to its higher oxidase activity over iron.

3 e first time, by a complex of earth-abundant iron.

4 patients have diminished capacity to process iron.

5 ce and randomly assigned to receive 12 wk of iron (60 mg; Fe group), MMNs (14 other micronutrients; M

6 ore or with the meal significantly increased iron absorption from FePP by 2.55-fold (95% CI: 1.48-, 4

7 Our study aim was to compare iron absorption from oral iron supplements given on cons

8 less well understood than the regulation of iron absorption in adults, which is inverse to iron stat

9 by the erythrocyte iron incorporation method.Iron absorption was 5.7% +/- 8.5% (TM-1), 3.6% +/- 4.2%

10 Iron absorption was assessed by isotope incorporation in

11 Fractional iron absorption was estimated by the erythrocyte iron in

12 not from FeSO4 There was a trend to increase iron absorption with the MNP+RUTF meal, which did not re

13 hypercoagulability, and increased intestinal iron absorption.

14 ) transporter internalization, impairing the iron absorption; clinically manifested as anemia of infl

15 Importantly, Pfn2-deficient mice showed iron accumulation in discrete areas of the brain (olfact

16 We tested the hypothesis that renal iron accumulation occurs and contributes to renal injury

17 d be differentiated according to hemosiderin iron accumulation-both in tumors and systemically.

18 include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (entero

19 Eurasia must have occurred early during the Iron Age.

20 Among the iron alkoxide and aryloxide catalysts evaluated, the iro

21 d natural community APase activity following iron amendment within the low zinc and moderately low ir

22 produced by Enterobacteriaceae for acquiring iron, an essential metal nutrient.

23 ere we determine the 3D coordinates of 6,569 iron and 16,627 platinum atoms in an iron-platinum nanop

24 s is an accumulation of excess intracellular iron and an augmented dependence on iron for proliferati

25 ce elements with Earth-abundant metals, with iron and copper being particularly attractive owing to t

26 They are assembled from iron and cysteine sulfur on protein scaffolds.

27 At the concentrations of iron and exudate used, iron was present as dissolved iro

28 ates many aspects of the alterations in free iron and iron-related proteins in cancer cells without a

29 Elevated dissolved iron and manganese concentrations at the fringe of the m

30 on is primarily mediated by the reduction of iron and manganese oxides.

31 ects model was used to assess the effects of iron and MMNs and the interaction between these factors.

32 ion of OC-complexed Fe to the total sediment iron and reactive iron pools, showing that 25-62% of tot

33 The production of ferrous iron and sulfide in conjunction with rapid oxidant consu

34 can act as powerful chelators for dissolved iron and thus enhance its export to the coastal ocean.

35 model was then completed by the addition of iron and various antioxidants in concentrations reflecti

36 oject sought to inform the interpretation of iron and vitamin A biomarkers (ferritin, serum transferr

37 aluating the effect of milk fortification on iron and vitamin D status in these children are scarce.

38 Feppt, combined with equilibration of sorbed iron and with Fe(II)aq using published fractionation fac

39 ental addition of haemoglobin (Hb) or ferric iron, and reduced following addition of the iron chelato

40 esent the effects of irradiation by protons, iron, and silver ions at MeV-level energies on a WSe2/6H

41 on of pmtA is specifically induced by excess iron, and this induction requires PerR.

42 (n = 115) after iron supplementation (60 mg iron as ferrous fumarate daily).

43 d computational studies increasingly support iron as the site of catalytic activity but differ with r

44 One group was given 60 mg iron at 0800 h (+/-1 h) on consecutive days for 14 days,

45 described so far, does not bind to the heme iron atom and has a novel binding mode.

46 ctive iron(V)oxo units (Fe(V)O), wherein the iron atom is two oxidation equivalents above the Fe(III)

47 SAM binds to the unique iron atom of a site-differentiated [4Fe-4S] cluster and

48 zed in conjunction with redox conditions and iron availability within the source zone to better asses

49 Hence, the cellular iron balance must be tightly controlled.

50 Moreover, these iron-based anti-perovskites are comparatively friendly t

51 the spin susceptibility across the cuprates, iron-based superconductors and many heavy fermion materi

52 thermally activated vortex motion (creep) in iron-based superconductors unveiled fast rates (S) compa

53 s, revealing dynamic structural changes upon iron binding and core formation, as reflected by a quick

54 present in the dissolved form as a result of iron binding by the organic exudate.

55 ich the length of the linker between the two iron-binding catecholamide units was increased from four

56 cles (OMVs) by directly interacting with the iron-binding Pseudomonas quinolone signal (PQS), a cell-

57 The relative iron bioavailability from FeFum+NaFeEDTA compared with F

58 uggest that water displacement from the heme iron can be affected in activator-bound CYP46A1.

59 This iron can be used for metabolic functions, stored within

60 Too little or too much iron can have important clinical consequences.

61 Iron-catalyzed cross-coupling reactions using alkynyl nu

62 n transfer from the substrate radical to the iron center followed by late ligand (Cl(-) or OH(-)) tra

63 iron, and reduced following addition of the iron chelator deferoxamine (DFO).

64 inositol hexakisphosphate (IP6), is the main iron chelator in cereals and bread.

65 This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to c

66 Iron complex [Fe(III)(N3)(MePy2tacn)](PF6)2 (1), contain

67 There were more reports of diarrhea in the iron complex group than in the ferrous sulfate group (58

68 (ferrous sulfate group) vs 7.7 to 11.1 g/dL (iron complex group), a greater difference of 1.0 g/dL (9

69 The iron complex is in equilibrium with an N2-free species.

70 A cationic iron complex, generated from the neutral precatalyst upo

71 No known iron complexes are considered photoluminescent at room t

72 Iron complexes bound by redox-active pyridine dialdimine

73 , changes in NOM consistent with the loss of iron-complexing carboxylate ligands were observed, inclu

74 ants grown on soil contain higher endogenous iron concentration than wild-type plants in both brown a

75 The last calculation assumes EUC dissolved iron concentrations from 140 degrees W'.

76 to thrive in environments where low soluble iron concentrations would otherwise preclude survival.

77 Therefore, safer formulations of iron-containing supplements and MNPs are needed.

78 d with a reduced dentate and caudate nucleus iron content compared to placebo.

79 cation ordering or a decrease in the ferric iron content of the lower mantle.

80 perties, growth rate, elemental composition, iron content, and oxidation state.

81 ession of iron proteins indicating increased iron content, oxidative stress and higher expression of

82 uantitative MRI relaxation times and hepatic iron content.

83 The nanoparticles comprising of iron core and carbon shell were decorated with ferrocene

84 ibition of their activity that fully stopped iron-coupled AOM.

85 challenged the prevailing view of the ocean iron cycle.

86 ld-scale evidence for changing conditions of iron cycling and stability of iron minerals it does not

87 ed the proportion of anemia with concomitant iron deficiency (defined as an inflammation-adjusted fer

88 Although the hazards associated with iron deficiency anemia (IDA) are well known, concerns ab

89 eople worldwide whose inadequate diet causes iron deficiency anemia.

90 y important in relation to the management of iron deficiency but should also inform dietary advice, e

91 ne for the genetic studies of abiotic stress iron deficiency chlorosis (IDC) of soybean is reported.

92 BRINDA findings confirm that iron deficiency is a common and consistent risk factor f

93 Despite its known detrimental effects, iron deficiency remains the most common micronutrient de

94 At 8 months, the risk for iron deficiency was reduced in the delayed clamping grou

95 mong patients without known risk factors for iron deficiency, gastric acid inhibitor use for >/=2 yea

96 emphasizes the complex relationship between iron deficiency, iron treatment, and malaria infection i

97 letion reduced cell viability in response to iron deficiency.

98 ng medication use and the subsequent risk of iron deficiency.

99 modifications during both erythropoiesis and iron deficiency.

100 ociated with an increased subsequent risk of iron deficiency.

101 hildren aged 9 to 48 months with nutritional iron-deficiency anemia, ferrous sulfate compared with ir

102 When tissue iron demands are high, hepcidin concentrations are low a

103 In root cells, HS triggered an iron-dependent cell death pathway that was characterized

104 ns contain anti-oxidant systems that include iron-dependent superoxide dismutases (SODs) in mitochond

105 ular renal injury was accompanied by nonheme iron deposition and hypoxia-inducible factor-1alpha upre

106 ht be attributable to microglial activation, iron deposition, and blood-brain barrier breakdown.

107 ubular brush border loss, diminished tubular iron deposition, blocked the development of interstitial

108 at higher numbers of infiltrating macrophage iron deposits was associated with lower anti-tumor chela

109 ients, LSIRs appeared to be related to focal iron deposits; this was proven with Perls staining in tw

110 s of Fe/S cluster biogenesis proteins during iron deprivation.

111 f the C-H amination reaction mediated by the iron dipyrrinato complex ((Ad) L)FeCl(OEt2 ) provided a

112 In neuronal cultures lithium attenuates iron efflux by lowering tau protein that traffics amyloi

113 fics amyloid precursor protein to facilitate iron efflux.

114 significant difference between aluminum and iron electrodes (P value of 0.0526-0.9487).

115 mice were protected against lithium-induced iron elevation and neurotoxicity.

116 cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal memb

117 nthesis protein EgtB, a mononuclear non-haem iron enzyme capable of catalysing the C-S bond formation

118 The di-iron enzyme ribonucleotide reductase (RNR) uses a diferr

119 a phagosomal membrane protein that controls iron export from vacuoles and inhibits Salmonella growth

120 which in turn results in decreased cellular iron export.

121 ies of children to test associations between iron exposures and mood, emotion, cognition, and memory;

122 establishment of human epigenetic markers of iron exposures and oxidative stress that could be monito

123 Two previously described iron (Fe) chelates of pentetic acid (Fe-DTPA) and of tra

124 Iron (Fe) oxide mineral concentrations were elevated in

125 ative siderophore, desferrioxamine B (DFOB), iron (Fe) was released at higher rates and to greater ex

126 of nitrogen (N), phosphorus (P), zinc (Zn), iron (Fe), and copper (Cu) in the fruit pulp was similar

127 upplements containing iron-folic acid versus iron-folic acid alone in 112 953 pregnant women.

128 ultiple micronutrient supplements containing iron-folic acid versus iron-folic acid alone in 112 953

129 cellular iron and an augmented dependence on iron for proliferation.

130 by considering the temporal record of banded iron formations and marine red beds.

131 The disappearance of banded iron formations at 1.8 billion years ago was traditiona

132 ears ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later.

133 Here we show that iron forms chemical bonds of similar strengths in basalt

134 ed using this process could be used as novel iron fortificants.

135 Iron from ferritin was nearly absent in young hearts, bu

136 eriprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomol

137 Except for Ni, all the iron-group elements, as well as most of the heavy elemen

138 al in nondiabetic DIOS patients with hepatic iron >50 mumol/g at magnetic resonance imaging to compar

139 r mechanisms that underlie the regulation of iron homeostasis and its disorders.

140 esent work, we study the effects produced on iron homeostasis by a wide range of copper concentration

141 eeding choice, infants' capacity to regulate iron homeostasis is important but less well understood t

142 s suggest that pathological changes in renal iron homeostasis occurs in lupus nephritis, contributing

143 predictive mathematical model of an expanded iron homeostasis pathway was constructed that includes s

144 understanding and knowledge gaps related to iron homeostasis, measurement of and evidence for iron s

145 layer of regulation in maintaining cellular iron homeostasis.

146 enzyme levels, white blood cell counts, and iron homeostasis.

147 regulate biosynthesis rates of the encoded, iron homeostatic proteins.

148 henol-like components bind on freshly formed iron hydroxides, a process that affects both DOC stabili

149 xide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition.

150 emphasizing the importance of the fac-C,N,S-iron(II) motif in promoting enzyme-like reactivity.

151 Iron(III)-catalyzed carbonyl-olefin ring-closing metathe

152 ation-level iron status and risk factors for iron imbalance.

153 smic data, implying the presence of metallic iron in an isochemical mantle.

154 crops to accumulate additional bioavailable iron in edible parts, thus improving the iron nutrition

155 evidence is uncertain regarding the role of iron in the development of gestational diabetes mellitus

156 nd to coincide with depletion of solid phase iron in the source zone.

157 viable spectrophotometry method to determine iron in wheat and maize flours was developed following a

158 nation of lead, cadmium, zinc, manganese and iron in white and wild rice samples.

159 The effect of iron incorporation into DrDps2 was investigated by stati

160 absorption was estimated by the erythrocyte iron incorporation method.Iron absorption was 5.7% +/- 8

161 lated and shown to grow autotrophically with iron, indicating a new biogeochemical role for this ubiq

162 concerns about risks associated with excess iron intake in young children are emerging.

163 lobally and that anemia control must combine iron interventions with control of infection and inflamm

164 Co-doping of strontium and iron into PrBaCo2O5+delta is found to be very effective

165 thereby facilitating an increased supply of iron into the circulation.

166 Iron is an essential metal for all organisms, yet disrup

167 pools, showing that 25-62% of total reactive iron is directly associated to OC through inner-sphere c

168 ction, a striking DFe isotope minimum (light iron) is observed at intermediate depths (200-1,300 m),

169 Coupling the co-localization results to iron K-edge X-ray absorption spectroscopy fitting result

170 Spatial profiling of the iron-laden infiltrates further demonstrated that higher

171 learly demonstrated that, in the presence of iron, large amounts of N-nitroso-tryptophan can be forme

172 hesis including an increase in mitochondrial iron levels, a decrease in the activities of Fe-S cluste

173 Iron-loaded transferrin binds to transferrin receptor 1

174 exudate used, iron was present as dissolved iron (<0.025 mum) at pH 4 but principally as small (<0.4

175 sis of crochelins and the mechanism by which iron may be removed upon import of the holo-siderophore

176 rt to better understand the linkages between iron metabolism and breast cancer, a predictive mathemat

177 n cancer exhibits a targetable alteration in iron metabolism.

178 The structures suggest a mechanism for iron mineral formation at the protein interface.

179 conditions of iron cycling and stability of iron minerals it does not provide a simple proxy for lon

180 with these chelators, ELT enhanced cellular iron mobilization more than additive (synergistic) with

181 Transport properties of tetragonal iron monosulfide, mackinawite, show a range of complex f

182 During pregnancy, iron needs to increase substantially to support fetoplac

183 and contained heterotrophs and oxidizers of iron, nitrite, and ammonium, whereas the other was abund

184 ble iron in edible parts, thus improving the iron nutrition of the billions of people worldwide whose

185 By increasing the field strength about iron, odd-electron reactivity was circumvented via incre

186 eview considers the specific effects of high iron on the brain, stem cells, and the process of erythr

187 absorption peak at 422 nm without releasing iron or sulfide from the clusters.

188 The re-dispersed soluble complexes of casein-iron-orthophosphate generated using this process could b

189 These data showed high sensitivity to iron overload and a strong relationship between quantita

190 ia in mice with either genetic or iatrogenic iron overload and in human plasma.

191 ed to embryonic lethality potentially due to iron overload in developing embryos.

192 Prevalence of fatty liver diseases and iron overload was calculated (weighted by probability of

193 ferroportin (Fpn), resulting in parenchymal iron overload.

194 A new enzyme-free sensor based on iron oxide (Fe3O4) nanodots fabricated on an indium tin

195 Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sen

196 noleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(

197 cylenate (oSUD) were chemisorbed to magnetic iron oxide nanoparticles (MNPs) through a single-step sy

198 , MER can also be used to capture changes in iron oxide reducibility during phase transformations, as

199 Beyond allowing to study iron oxide reduction under defined thermodynamic conditi

200 Here, we use iron oxide-loaded ferritin proteins to create a stable a

201 ormula: see text]m-long microrods containing iron-oxide nanoparticles connected by a polymer mesh.

202 predominantly co-located with aluminium and iron oxides and hydroxides, which are known to strongly

203 Iron oxides are important structural and biogeochemical

204 perior performance in comparison to the pure iron oxy-hydroxide (FeOOH) catalysts, originate from the

205 characterization and reactivity of important iron-oxygen intermediates.

206 ransformation rate of the poorly crystalline iron (oxyhydr)oxide, ferrihydrite, to more crystalline f

207 Specifically, galvanic corrosion of lead by iron (oxyhydr)oxides was investigated.

208 n of trace uranium associated with nanophase iron (oxyhydr)oxides, a model system for the geochemical

209 at pH 4 but principally as small (<0.45 mum) iron oxyhydroxide particles at pH 8 with only approximat

210 his flux decreased slightly after scaling by iron oxyhydroxide; however, membranes maintained >99% di

211 rs proposed the formation of an intermediate iron-peroxo complex but experimental evidence for its ex

212 Bmp6 conditional knockout mice exhibited no iron phenotype.

213 oxide and aryloxide catalysts evaluated, the iron phenoxide complex exhibited superior performance to

214 Lithium iron phosphate acts effectively as a reversible redox ag

215 ithiation dynamics of single-crystal lithium iron phosphate microrods with long-axis along the [010]

216 king and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss r

217 f 6,569 iron and 16,627 platinum atoms in an iron-platinum nanoparticle, and correlate chemical order

218 , MMNs (14 other micronutrients; MMN group), iron plus MMNs (Fe+MMN group), or placebo capsules.

219 EuFe2As2-based iron pnictides are quite interesting compounds, due to t

220 ciency anemia, ferrous sulfate compared with iron polysaccharide complex resulted in a greater increa

221 d Fe to the total sediment iron and reactive iron pools, showing that 25-62% of total reactive iron i

222 is broader than those of enzymes containing iron porphyrins.

223 Here, we found different expression of iron proteins indicating increased iron content, oxidati

224 tin protoporphyrin IX (SnPP) decreased heme-iron recycling in the liver and ameliorated anemia in th

225 Given plausible iron recycling rates, seasonal variability in nitrate co

226 driven in part by fungal respiration and/or iron redox cycling.

227 vity but differ with respect to the relevant iron redox state.

228 ore crystalline forms in the presence of the iron reducing bacterium Shewanella oneidensis MR-1 are i

229 d the effects of DOM on Hg methylation by an iron-reducing bacterium Geobacter sulfurreducens PCA and

230 slower upwelling allowing for more cycles of iron regeneration and uptake.

231 (PhuS) is required for interaction with the iron-regulated heme oxygenase (HemO).

232 Additionally, an iron-regulated metastasis suppressor interacts with the

233 The iron-regulated metastasis suppressor N-myc downstream-re

234 The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspe

235 The iron-regulatory hormone hepcidin is induced early in inf

236 The second prediction is that iron-related proteins are dramatically affected by mitoc

237 aspects of the alterations in free iron and iron-related proteins in cancer cells without affecting

238 three-quarters of children were found to be iron replete, and excess iron stores (SF >100 mug/L) did

239 iron status before interventions to exclude iron-replete individuals).

240 s, and emerging concerns about supplementing iron-replete members of these vulnerable populations.

241 Estimates of iron-replete status cannot be made at this time in the a

242 me in the absence of established cutoffs for iron repletion based on TBI.

243 Dietary iron repletion completely reversed ID anemia and ineffec

244 in vivo MRI assessments of non-heme cellular iron revealed that preclinical prostate tumor models cou

245 of similar strengths in basaltic glasses and iron-rich alloys, even at high pressure.

246 Among other factors iron-rich reactor and feedstream impurities cause these

247 These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metab

248 cidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma i

249 erstanding of the mechanism of long-distance iron signaling will allow improved strategies for the en

250 globin (Hb) to enable growth on Hb as a sole iron source.

251 Here we present iron-speciation, redox-sensitive trace element, and nitr

252 climation of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via postt

253 l response invoked by paracrine signals from iron-starved astrocytes.

254 is available on the current population-level iron status and risk factors for iron imbalance.

255 on absorption in adults, which is inverse to iron status and strongly upregulated or downregulated.

256 lications (e.g., the necessity to screen for iron status before interventions to exclude iron-replete

257 by oxidative stress that is imparted by high iron status in early life.

258 TBI has been used to assess iron status in the United States, but its use worldwide

259 Efforts to optimize iron status should keep these findings in view.

260 blood samples from 20 participants to assess iron status using ironPhone and compared the results wit

261 homeostasis, measurement of and evidence for iron status, and emerging concerns about supplementing i

262 itin (SF) concentrations as the indicator of iron status, which makes the interpretation of results c

263 rum ferritin so that two groups with similar iron statuses could be formed.

264 rt protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the ch

265 , and midbrain) and reduction of the hepatic iron store without anemia.

266 en were found to be iron replete, and excess iron stores (SF >100 mug/L) did not appear to be a conce

267 s AGP), the estimated prevalence of depleted iron stores increased by 7-25 and 2-8 absolute median pe

268 reased covalencies in both iron-thiolate and iron-sulfide bonds would stabilize the oxidized state of

269 d in the matrix where also the mitochondrial iron-sulfur (Fe/S) cluster assembly machinery resides to

270 lytic H-cluster, CpI contains four accessory iron-sulfur [FeS] clusters in a branched series that tra

271 he WhiB1 structure suggests that loss of the iron-sulfur cluster (by nitrosylation) permits positivel

272 at cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1.

273 unusual cytidilation reaction and the use of iron-sulfur cluster cofactors in reductive ring opening

274 rdination sphere of the outermost, "distal", iron-sulfur cluster.

275 stood roles performed by multiple, auxiliary iron-sulfur clusters and the paucity of protein X-ray st

276 9 days (n = 112) and 84 days (n = 115) after iron supplementation (60 mg iron as ferrous fumarate dai

277 If true, iron supplementation will not be an effective anemia red

278 IDA patients can be treated with iron supplementation, yet TT patients have diminished ca

279 aim was to compare iron absorption from oral iron supplements given on consecutive versus alternate d

280 ed that Ent can chelate intracellular labile iron that is required for neutrophil oxidative responses

281 iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin.

282 f chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracel

283 Increased covalencies in both iron-thiolate and iron-sulfide bonds would stabilize the

284 stration in macrophages and decreased plasma iron; this is proposed to limit the replication of extra

285 with magnetic resonance imaging to quantify iron through R2* map at 24-72 h and at 1-year follow-up.

286 Key players in mammalian iron trafficking include several types of cells importan

287 etal hepcidin in the regulation of placental iron transfer still remains to be characterized.

288 y hemochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in parench

289 omplex relationship between iron deficiency, iron treatment, and malaria infection in endemic areas;

290 porter-1 (DMT-1), indicating PrP(C)-mediated iron uptake through DMT-1.

291 te both recycling-dependent and -independent iron uptake.

292 res early signaling components with the root iron-uptake machinery.

293 onstructed that includes species involved in iron utilization, oxidative stress response and oncogeni

294 gave the structurally authenticated reactive iron(V)oxo units (Fe(V)O), wherein the iron atom is two

295 the concentrations of iron and exudate used, iron was present as dissolved iron (<0.025 mum) at pH 4

296 synthesise many of the elements heavier than iron.) We identify line features in the spectra that are

297 dment within the low zinc and moderately low iron Western North Atlantic.

298 rawal of essential metal ions, in particular iron, which leads to "nutritional immunity".

299 trategy.We measured the effect of daily oral iron with or without multiple micronutrients (MMNs) on h

300 They compete for iron with soil-borne pathogens or induce a systemic resi