ライフサイエンスコーパス: labeled at

1 administered daily in controlled oral doses labeled at 0, 25, 125, and 250 micro g cholecalciferol f

2 Intrinsic KIEs from MTAs labeled at 1'-(3)H, 1'-(14)C, 2'-(3)H, 4'-(3)H, 5'-(3)H,

3 In this work, FRP was labeled at 1:1 molar ratio with the fluorophore eosin.

4 The protein was labeled at 11 water-exposed and lipid-covered sites, and

5 ing activity was enriched in organelles that labeled at 15 degrees C, but not at 4 degrees C, that ex

6 t only 13% of the lens epithelial cells were labeled at 18.5 weeks.

7 of the peptic fragments derived from alphaTS labeled at 3 M urea indicates that most of the region be

8 Only RPE65 is labeled at 5 microM 1 at 4 degrees C.

9 capture probe (CP) with methylene blue (MB) labeled at 5' end is modified on the pretreated electrod

10 DNA labeled at 5'end using 6-mercapto-1-hexhane (HS-ssDNA) i

11 Adenines labeled at [6-13C], [6-15N], [6-13C, 6-15N], and [1-15N]

12 illin headpiece subdomain protein (HP36) was labeled at a "single" site corresponding to any one of t

13 The 35-kDa band was half-maximally labeled at a [(3)H]6-AziP concentration of 1.9 microM, w

14 ion was found to be much longer lived, being labeled at a rate of only 0.2% per day (corresponding to

15 Chloroplast ATPase F1 was labeled at a single cysteine residue by OPBM and trypsin

16 The annexin V-128 protein, labeled at a single specific site at the N terminus, sho

17 g technique, in which one type of subunit is labeled at a time, to carbonmonoxy-hemoglobin A (HbCO A)

18 Second, we have used S4 labeled at a unique cysteine with either of two fluoroph

19 tested using a set of HFPs that were (13)CO-labeled at Ala-14 and (15)N-labeled at either Val-2, Gly

20 On the (+)-side, alpha1M3 was labeled at Ala-291 and Tyr-294 and gamma2M3 at Ser-301,

21 CB(1)(T377-E416) specifically (2)H- or (15)N-labeled at Ala380 and reconstituted in membrane-mimetic

22 pffs in neurons, we developed a pff species labeled at amino acid residue 114 with the environmental

23 occur upon binding of a T4L variant, bimane-labeled at an alternative solvent-exposed site, establis

24 CNV complexes are labeled at an earlier stage and more reproducibly than w

25 oving limitations on the quantity of protein labeled at any one time significantly decreases the cost

26 andard assay, one end of the dsDNA helix was labeled at apposing 5' and 3' ends with hexachlorofluore

27 in a series of Sup35NM fibril samples, (13)C-labeled at backbone carbonyl sites of Tyr, Leu, or Phe r

28 kinetics of DNA bending by M.EcoRI using DNA labeled at both 5'-ends and observed changes in fluoresc

29 escent double-stranded DNA (dsDNA) molecules labeled at both ends are commonly produced by annealing

30 ts and lengths of up to 75 A, have been spin-labeled at both ends with stable nitroxide TEMPO radical

31 ent label at the N-terminus, and another one labeled at both ends.

32 6-position and approximately 4-fold for DHO labeled at both the 5- and 6-positions.

33 t the 6-position, and about 6-7-fold for DHO labeled at both the 5- and 6-positions.

34 e TATA box binding protein was photoaffinity labeled at bp -26/-21 with nucleotide analogs containing

35 it of TFIIIB (Mr = 90 kDa) was photoaffinity labeled at bps -26/-21 with DNA containing a approximate

36 s detected when histidine specifically (13)C-labeled at C-2 of the imidazole ring was used, providing

37 3 and D-talose 8 selectively (13)C- and (2)H-labeled at C1 and H1.

38 The stearate spin-labeled at C5 has the highest affinity for the lipoxygen

39 (111)In- and (90)Y-ibritumomab tiuxetan are labeled at commercial radiopharmacies and delivered for

40 eria toxin transmembrane (T) domain was spin-labeled at consecutive residues in a helical segment, TH

41 GluR4-receptor subunits labeled at corticothalamic synapses on RTN neurons outnu

42 skinned psoas fibers reconstituted with sTnC labeled at Cys 98 with 5'ATR, dichroism was maximal duri

43 cdb3 was labeled at Cys-201 with fluorescein maleimide.

44 ence of a mutant Galphat (Chi6b) selectively labeled at Cys-210.

45 The catalytic domain of the myosin head was labeled at Cys-707 with indane dione spin label; the reg

46 A genetically engineered cardiac TnC mutant labeled at Cys-84 with tetramethylrhodamine-5-iodoacetam

47 ne mutant of the protein (C35S) specifically labeled at Cys-84 with the fluorescent probe 2(-)[4'-(io

48 zard myosin regulatory light chain (RLC) was labeled at Cys108 with either the 5- or the 6-isomer of

49 The essential light chain was labeled at Cys177 with the indanedione spin-label follow

50 te binding protein (PBP) and the same mutant labeled at Cys197 with N-[2-(1-maleimidyl)ethyl]-7-(diet

51 ingly, RTryp complexes containing alpha(1)PI labeled at Cys232 with a cationic fluorophore display tw

52 MPO leads to an inactive enzyme that is spin-labeled at cys273.

53 Chi6a labeled at Cys347 also showed an AlF4--dependent increas

54 conformation and dynamics of actin filaments labeled at Cys374 with erythrosin-iodoacetemide (ErIA),

55 ds (S1) on the microsecond dynamics of actin labeled at Cys374 with erythrosine iodoacetamide.

56 led by EPR studies on hCB(1)(T377-E416) spin-labeled at Cys382 and reconstituted into the phospholipi

57 efolding kinetics of iso-1-cytochrome c spin-labeled at Cysteine 102.

58 etected by fluorescence spectroscopy of gHgL labeled at cysteine 153 at the domain I-domain II interf

59 ght chain and re-addition of the light chain labeled at cysteine-108 with the 6-isomer of iodoacetami

60 By all physical evidence, the protein labeled at cysteine102 folded, but the spin probe in thi

61 bled from DNA fragments such that a chain is labeled at designated spots with covalently attached flu

62 arison of REDOR spectra on samples that were labeled at different residue positions suggests that the

63 measurements between eight Rep mutants donor-labeled at different residues and pdDNA acceptor-labeled

64 ithelial cells undergoing DNA synthesis were labeled at discrete time points following abrasion.

65 des from bovine fibrinogen were fluorescence labeled at each branch specifically for conformational s

66 emical shifts were carried out in constructs labeled at either Ala-6 or Ala-15.

67 Caldesmon was labeled at either Cys-153 in the NH2 domain or Cys-580 i

68 Caldesmon was labeled at either Cys-153 in the NH2-terminal domain or

69 ned by spin dipolar quenching in six samples labeled at either the cytoplasmic or extracellular ends

70 that were (13)CO-labeled at Ala-14 and (15)N-labeled at either Val-2, Gly-3, Ile-4, or Gly-5.

71 d identical experiments on both myosins spin-labeled at equivalent sites.

72 nce: KKITLIIFG(79)VMAGVIGTILLISWG(94)IKK was labeled at G(79) and G(94) with (13)C=(16)O or (13)C=(18

73 Q(2)A-alpha(2)AP was also labeled at Gln(21) > Gln(419) > Gln(447), but became cro

74 Actin labeled at Gln-41 with dansyl ethylenediamine (DED) via

75 atidylinositol-specific phospholipase C spin-labeled at H82C, a position near the active site of the

76 In contrast, when the right SHF was labeled at HH18, the fluorescence was limited to the cau

77 their bipotential progenitors) are heritably labeled at high efficiency with yellow fluorescent prote

78 n of 1.9 microM, whereas the 60-kDa band was labeled at higher concentrations.

79 ent base, 2-aminopurine (2-AP), and dT(pT)15 labeled at its 3'-end with fluorescein (3'-F-dT(pT)15).

80 fied free target protein can be specifically labeled at its C-terminus.

81 fluorescence enhancement of a reference DNA labeled at its end with a Cy3 fluorophore.

82 tes resolution, to observe a growing peptide labeled at its N terminus with the fluorophore tetrameth

83 ldihydrotestosterone, a steroid that is spin-labeled at its solvent-exposed end, induced the selectiv

84 region) also project to both tissues but are labeled at later times.

85 More spinal and brainstem neurons were labeled at longer survival times.

86 Although occasional brainstem nuclei were labeled at low levels by embryonic day 18, the majority

87 orporation and alphaCys-192 and alphaTyr-198 labeled at lower efficiency.

88 NMR measurements on OspA specifically 15N-labeled at Lys residues identified the locations of the

89 To accomplish this goal, PLB was labeled at Lys-3 in the cytoplasmic domain, with two dif

90 nding with three well-characterized proteins labeled at lysine residues: calmodulin (CaM), maltose-bi

91 at Ser-301, and on the (-)-side, beta3M1 was labeled at Met-227.

92 Neuronal clones in the ferret labeled at middle to late neurogenesis (embryonic day 33

93 aromyces cerevisiae iso-1 ferricytochrome c (labeled at mutant Cys residues 4, 39, 50, 66, and 99) by

94 genomic restriction fragments that were end-labeled at NotI cleavage sites.

95 The fluorogenic peptide was labeled at one end with a UV/blue fluorophore (N-methyla

96 Arp2/3 actin nucleation complex selectively labeled at one subunit and obtained (1)H/(13)C-HSQC spec

97 X-MS experiments using unstructured peptides labeled at pD 4.0 under crowded and uncrowded conditions

98 For nonreduced preparation, rMAbs are labeled at pH 6.5 with a dye-to-protein (D/P) molar rati

99 For reduced preparation, rMAbs are labeled at pH 9.3 with a D/P molar ratio of 10:1, which

100 ant near 300 nM was determined for a variant labeled at position 12, in the N-terminal domain.

101 ssociation constants near 30 nM for variants labeled at position 33, in the N-terminal domain, and po

102 ualifying differences seen with the receptor labeled at position 417, which had motion between the in

103 e particularly illustrative for the receptor labeled at position 530, which had motion between the fa

104 [(11)C]PD153035 labeled at position 6 was metabolized extensively in viv

105 domonas reinhardtii (CrChR2) was selectively labeled at position Cys-79 at the end of the first cytop

106 ycosides into the emissive A-site construct, labeled at position U1406, shows a decrease in donor emi

107 The peptide is 13Calpha-labeled at position V9(a) and results are compared with

108 We found that the fibrils labeled at positions 127, 144, 196, and 230 displayed co

109 for the alkaline phosphatase signal peptide labeled at residue 22 or 2, respectively, with SecA, and

110 unfolding, whereas the unfolding of fibrils labeled at residue 88 was non-cooperative.

111 eukocyte antigen (HLA)-DR A and B genes were labeled at saturation with a univalent probe consisting

112 employed to detect local motions of Galphai1 labeled at selected sites with Alexa 488 (C5) fluorescen

113 eptors were expressed in Xenopus oocytes and labeled at selected sites with environment-sensitive flu

114 Fibers were extensively and predominantly labeled at SH1 (Cys-707) of the myosin heavy chain with

115 Spectra of arrestin spin-labeled at site 267 were recorded at room temperature as

116 Two separate derivatives, labeled at sites 44 and 69, were analyzed.

117 heW, and an engineered single-chain receptor labeled at six different sites allow docking of the rece

118 ters formed in the presence of symmetric PCs labeled at sn-2.

119 It was labeled at specific activities of 1.1-2.7 mCi/mg using N

120 ole-dipole couplings in samples that are 13C-labeled at specific sites and two-dimensional 15N-13C an

121 We find that progenitor cells labeled at stage 19-22 can give rise to multiple cell ty

122 We show that when labeled at tail somite 15-17 stages, corresponding to 11

123 When labeled at tail somite 18-20 stages, corresponding to 11

124 The S179C variant of GlnBP was labeled at the -SH and N-terminal positions with acrylod

125 mide gel electrophoresis of samples that are labeled at the 3'- or 5'-terminus with (32)P.

126 le while the other nucleic acid fragment was labeled at the 3'-end by a dansyl molecule prone to be i

127 ontaining mRNA in total RNA was detected and labeled at the 3(')-terminal on a poly(T) template.

128 In these studies, we used DNA substrates labeled at the 5' end of the template strand and the 5'

129 The oligodeoxyribonucleotide was labeled at the 5' end with 32P and at the 3' end with a

130 t oligonucleotide probes that are covalently labeled at the 5' end with a fluorophore and at the 3' e

131 d by an oligonucleotide "tail" fluorescently labeled at the 5' end.

132 amics of a 20-mer HIV-1 RNA stem loop 3 spin-labeled at the 5' position were probed in the nanosecond

133 ling reduction and were about 3-fold for DHO labeled at the 5-position, about 4-fold for DHO labeled

134 At pH 8.5, the KIEs observed for DHO labeled at the 5-position, the 6-position, and the 5- an

135 eled at the 5-position, about 4-fold for DHO labeled at the 6-position, and about 6-7-fold for DHO la

136 As occurred in protease complexes with crmAs labeled at the 68 and 261 positions, but not the P1' pos

137 reinhardtii, to yield the enzyme selectively labeled at the [2Fe]H subcluster.

138 Further studies with Pm labeled at the active site with 2-anilinonaphthalene-6-s

139 deletion mutant (SKDeltaK414) binding to Pm labeled at the active site with 5-fluorescein ([5F]FFR-P

140 (mAbs), two of which block EPCR/Fl-APC (APC labeled at the active site with fluorescein) interaction

141 dynamic exchange was detected with pre-mRNA labeled at the AG dinucleotide of the 3' splice site.

142 otope effect was determined for benzaldehyde labeled at the aldehyde position and found to be small (

143 pG sites in the (GCC)n hairpins that are 15N-labeled at the amino (N4) groups of specific cytosine ba

144 of replicons in replicon clusters that were labeled at the beginning of one S phase were also labele

145 ed at the beginning of one S phase were also labeled at the beginning of the next.

146 opsin that was regenerated with retinal (2)H-labeled at the C(5), C(9), or C(13) methyl groups by tot

147 Often the nicotinamide ring is labeled at the C-4 position which is directly involved i

148 was regenerated using retinal that was (2)H-labeled at the C5, C9, or C13 methyl groups and was reco

149 (Pg), which are specifically inactivated and labeled at the catalytic site have been prepared and cha

150 d to create novel analogs of ProT covalently labeled at the catalytic site with fluorescence probes.

151 ional COOH-terminal residues, GMLC, and then labeled at the COOH-terminal cysteine with fluorescein 5

152 aled by both the failure of veg1 descendants labeled at the eighth equatorial division to segregate p

153 m)Tc-HYNIC-annexin V showed that the protein labeled at the endogenous chelation site had the same or

154 Tritiated adenosylcobalamin, labeled at the exchangeable position, has been used to i

155 sonance energy transfer (FRET), using lipids labeled at the headgroup with pyrene (Py) as donors and

156 und 6b was demonstrated to be >/=95% tritium-labeled at the imine position by NMR spectroscopy, and t

157 led at different residues and pdDNA acceptor-labeled at the junction were conducted at each of the fo

158 -time dynamic coupling between the ribosome, labeled at the L1 stalk, and transfer RNA (tRNA).

159 Transgenic mice labeled at the M71 odorant receptor (specifically activa

160 Each peptide was specifically labeled at the MAG3 chelation sites at ambient temperatu

161 L-AE (S = (1)/(2)) in the presence of AdoMet labeled at the methyl position with either (2)H or (13)C

162 nstructs of Galphai/o subunits fluorescently labeled at the N terminus (GAP43-CFP-Galphai/o) seem to

163 In addition, using active terminases labeled at the N- and C-terminal ends with a single dye

164 ide (ODN) containing a cis-syn thymine dimer labeled at the N3 of both T's with 15N by two efficient

165 When crushed optic nerve was retrogradely labeled at the nerve stump, no labeling of retinal neuro

166 ivity was also investigated on cellopentaose labeled at the nonreducing end with 14C, and cellooligos

167 results in the surface of DNA being randomly labeled at the phosphorothioate sites with this protein-

168 fate chains were purified from CHO cells and labeled at the reducing end with [3H]NaBH4.

169 Muscle was labeled at the regulatory domain by replacing native ess

170 Studies with this substrate labeled at the RNA 3' end showed that Y181C is no more l

171 ions of the molecule, except the C-terminus, labeled at the same nine axial positions in each half A-

172 ed molecules, and thus many molecules can be labeled at the same time and within the point spread fun

173 dione spin label; the regulatory domain was labeled at the single cysteine residue of the essential

174 C102T variant of yeast iso-1-cytochrome c is labeled at the single cysteine residue on the back surfa

175 102T variant of yeast iso-1-cytochrome c was labeled at the single cysteine residue with a tris (bipy

176 With this method, peptides get labeled at their C-terminus, at Asp and Glu residues, an

177 rminals of B-type horizontal cells were also labeled at their contacts with rod spherules.

178 pproach, surface bound peptides, selectively labeled at their N-termini with a positive charge-bearin

179 fer (FRET) experiments conducted on peptides labeled at their N-termini with either tetramethylrhodam

180 are based on probe oligonucleotides that are labeled at their opposite termini with Tb and a fluoresc

181 Of 205 GAD67-ir cells labeled at these sites, 74% exhibited immunoreactivity f

182 data on ligand-free GlnBP, paramagnetically labeled at two sites (one at a time), could be appropria