ライフサイエンスコーパス: mechanical force

1 ll has long been considered to be subject to mechanical force.

2 by extension the LINC complex, is subject to mechanical force.

3 roviding tethering for TGFbeta activation by mechanical force.

4 ies in polymeric materials is achieved using mechanical force.

5 the cytoskeleton could provide the necessary mechanical force.

6 cally couple neighboring cells and withstand mechanical force.

7 or removal of ligands or the application of mechanical force.

8 rely on the ability to detect and transduce mechanical force.

9 the unfolding transition state to an applied mechanical force.

10 tic cation-selective channel that opens with mechanical force.

11 nt mutants at 100 mM KCl concentration under mechanical force.

12 the translocon has been proposed to occur by mechanical force.

13 ion in cells only in the presence of applied mechanical force.

14 ere anchoring devices, deforming bilayers by mechanical force.

15 above a substrate, associated with a recoil mechanical force.

16 on, and enabling cells to migrate and resist mechanical force.

17 CM adhesions are stabilized upon exposure to mechanical force.

18 d fluorescence quenching under the action of mechanical force.

19 n and become longer lived in the presence of mechanical force.

20 late how strongly sensory neurons respond to mechanical force.

21 further how Piezo channels are regulated by mechanical force.

22 tures that adapt their growth in response to mechanical force.

23 roposed mechanisms, enzymatic liberation and mechanical force.

24 Cells continuously exert or respond to mechanical force.

25 sically active structure capable of exerting mechanical force.

26 light the interplay between each pathway and mechanical forces.

27 n increase in the strength and anisotropy of mechanical forces.

28 r (TCR) integrates both binding kinetics and mechanical forces.

29 valent GAG.protein bonds respond to directed mechanical forces.

30 ing area and that this behavior depends upon mechanical forces.

31 een the channel's responses to two different mechanical forces.

32 All living organisms sense mechanical forces.

33 eractions between the actin cytoskeleton and mechanical forces.

34 important role in the channel's response to mechanical forces.

35 hout conventional heating sources or applied mechanical forces.

36 ling of the adherens junction in response to mechanical forces.

37 se cell shape and the direction of extrinsic mechanical forces.

38 adhesions respond to increased and decreased mechanical forces.

39 d shark skin and were robust with respect to mechanical forces.

40 that is known to be triggered by repetitive mechanical forces.

41 the bacterial surface and resist significant mechanical forces.

42 growth in response to external or intrinsic mechanical forces.

43 n NE spacing in cells subjected to increased mechanical forces.

44 plastic substrates can generate substantial mechanical forces.

45 interfering with the exploitation of passive mechanical forces.

46 ogical and structural changes in response to mechanical forces.

47 l known that it releases 5-HT in response to mechanical forces.

48 w that mitochondrial fission is triggered by mechanical forces.

49 niche through secreting factors and exerting mechanical forces.

50 , suggesting local network reorganization by mechanical forces.

51 cell releases this serotonin in response to mechanical forces.

52 ltered by a variety of different conditions, mechanical forces across the LINC complex, as well as th

53 Thus, mechanical forces act through a central feedback circuit

54 terconnected network upon which haemodynamic mechanical forces act to control vascular tone and remod

55 In a more general framework, mechanical forces acting on a molecular system can stron

56 s shift can be interpreted as changes in the mechanical forces acting on the cortex.

57 shaped by growth, detachment and response to mechanical forces acting on them.

58 Mechanical forces affect all the tissues of our bodies.

59 Despite the observation that mechanical forces affect nuclear geometry and movement,

60 (up to 21 kbp) linear molecules stretched by mechanical forces akin to magnetic tweezers contain, in

61 Mechanical forces also appear to have an important role

62 ress in understanding how pressure-dependent mechanical forces alter networked Ca(2+) signalling.

63 ons such as high temperatures, pressures and mechanical force, among others.

64 ion of rocks due to elevated climate-related mechanical forces (an increasing frequency of days with

65 footpad and exhibit enhanced sensitivity to mechanical force and innocuous cold temperatures.

66 enerates much higher output power by a small mechanical force and integrates piezoelectric generator

67 600 LED bulbs by the application of a 0.2 N mechanical force and it charged a 10 muF capacitor to 10

68 pyran bond with the direction of the applied mechanical force and its effect on mechanochemical trans

69 rates and have crucial roles in transmitting mechanical force and linking organs.

70 isions and is distinctive in its reliance on mechanical force and protein glycosylation.

71 we use a combination of chemical denaturant, mechanical force and site-directed mutations to demonstr

72 However, it is unknown whether mechanical force and Wnt signaling act independently or

73 Mechanical force and Wnt signaling activate beta-catenin

74 m, continuous and progressive regulation via mechanical forces and aberrant signaling are believed to

75 lular matrix (ECM) components that can exert mechanical forces and affect nuclear structure.

76 s, synovial fibroblasts exposed to anomalous mechanical forces and an inflammatory microenvironment r

77 uctural properties, particularly by exerting mechanical forces and by serving as a scaffold for bindi

78 adherin-based adhesions adapt and respond to mechanical forces and cell density, while tight junction

79 ow that rheotaxis can be explained solely by mechanical forces and does not require sensory input or

80 Here we show that ECs integrate mechanical forces and extracellular matrix (ECM) cues to

81 hesion pathway as a fulcrum for transmitting mechanical forces and regulatory signals.

82 In addition to generating mechanical forces and sensing mechanical deformation, dy

83 the ability of the cell's machinery to sense mechanical forces and tune the force-generating machiner

84 nd robust conversion between electricity and mechanical force, and arises from the broken inversion s

85 arding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel seq

86 NA during ES indicate that DNA is damaged by mechanical forces, and the damage takes place in the vic

87 Mechanical force applied on ICAM-1 impairs CD2AP binding

88 ellular mechanosensation, a process by which mechanical forces applied on the cell membrane are conve

89 into shorter MTs have been reported due the mechanical forces applied on the MT during transport.

90 inding affinity of particles is modulated by mechanical forces applied to the ends of the fiber.

91 Mechanical forces, applied via covalent polymer mechanoc

92 Ion channels that sense mechanical force are postulated to play critical roles i

93 Mechanical forces are critical but poorly understood inp

94 The mechanical forces are determined using a computational (

95 g evidence in eukaryotic cells suggests that mechanical forces are essential for building a robust mi

96 forms a barrier between the cytoplasm, where mechanical forces are generated, and the nucleoskeleton.

97 Mechanical forces are increasingly recognized to influen

98 Mechanical forces are increasingly recognized to regulat

99 Because mechanical forces are inherent in the cellular environme

100 Mechanical forces are integral to many biological proces

101 r scales, it is increasingly recognized that mechanical forces are involved in the modulation of size

102 Mechanical forces are key regulators of cell and tissue

103 ge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mech

104 We find that localized mechanical forces are sufficient to induce the formation

105 trol gene expression, it remains unclear how mechanical forces are transduced through the nucleus.

106 stantly inform plant growth and development, mechanical forces are unique in that they are an intrins

107 a mechanical barrier that can be overcome by mechanical force as well as disruption of the cytoskelet

108 Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientati

109 ese neurons are very long and exposed to the mechanical forces associated with limb movement; most la

110 essential components of a mechanism whereby mechanical forces associated with the establishment of c

111 ction of protein barnase under the action of mechanical force at the single-molecule level using opti

112 how the cadherin-catenin complex transduces mechanical forces at cell-cell junctions.

113 Here, starting with mechanical force balance at the cell cortex, and the rec

114 Among them, the emerging mechanical force-based stimulus offers a convenient and

115 Mechanical forces between cells and their extracellular

116 ammalian) cells in our body are sensitive to mechanical forces, but little work has been done to deve

117 first examine the detection and encoding of mechanical forces by primary mechanoreceptor neurons.

118 The work reveals that a mechanical force can shift the redox potential of a mole

119 ition to locally acting signals, tissue-wide mechanical forces can act as organizing cues, and that t

120 , providing a molecular understanding of how mechanical forces can modulate organ growth.

121 Mechanical forces can strengthen (catch) or weaken (slip

122 cell shape, driven by gene expression and/or mechanical forces, can promote breast cancer progression

123 Thus, the relative strengths of two opposing mechanical forces--contractility and cell-substrate adhe

124 flagella are model systems for studying how mechanical forces control morphology.

125 uire Piezo1 at the steady state, the type of mechanical force controls the outcome: stretch induces c

126 ation, while coupling of thermal effects and mechanical forces controls the stability of the clusters

127 evels, we reveal how spatial segregation and mechanical force cooperate to direct receptor activation

128 logical processes by responding to exogenous mechanical forces directed through sub-cellular componen

129 d muscle-like biomimetic systems to generate mechanical force directly from chemical reactions.

130 hich can be manipulated in vitro by applying mechanical forces directly on the nucleic acid strands.

131 physiological processes.Proteins fold under mechanical force during co-translational folding at the

132 sin contractility locally to generate robust mechanical forces during axis elongation.

133 NMDA receptors (NMDARs) are key in mediating mechanical forces during TBI, and that TBI produces a co

134 w, using simulations of src SH3 domain, that mechanical force enhances the population of the aggregat

135 e cell-substrate contact can be regulated by mechanical force, especially at the focal adhesion.

136 We conclude that polymerized actin provides mechanical force essential for all kinetically distingui

137 The epithelial junction experiences mechanical force exerted by endogenous actomyosin activi

138 Together, these studies show that mechanical force exerted by signal-sending cells is requ

139 ay between their material properties and the mechanical forces exerted on them.

140 activated by shear stress, the major type of mechanical force experienced by endothelial cells in res

141 role, but whether this is relevant under the mechanical forces experienced by endothelial cells in vi

142 that nodal alphaII spectrin helps resist the mechanical forces experienced by large-diameter axons, a

143 ical ventilation and the resultant excessive mechanical forces experienced by lung vascular endotheli

144 For folded Spy0125 without mechanical force exposure, thioester cleavage was in equ

145 function of denaturant concentration ([C]), mechanical force (f), and temperature exhibit an apparen

146 n and resort to enzymatic liberation only if mechanical forces fail to retrieve antigen.

147 of the oxygen vacancy distribution using the mechanical force from a scanning probe microscope tip.

148 hat are predicted to experience the greatest mechanical force from ciliary beating.

149 Endothelial cells transduce mechanical forces from blood flow into intracellular sig

150 ical structure that mediates the transfer of mechanical forces from the cytoskeleton onto the nucleus

151 escribe the response of a PK over a range of mechanical forces (fs) and monovalent salt concentration

152 tically on an animal's ability to respond to mechanical forces generated both within and outside the

153 with the F-actin cytoskeleton and transduce mechanical forces generated by the actin retrograde flow

154 and migration, rely on its ability to endure mechanical forces generated by the cytoskeleton on the n

155 ined with diffusion on the cell membrane and mechanical forces generated in the cortex, can determine

156 of cytoskeletal protein filaments is key for mechanical force generation driving animal tissue morpho

157 Current methods for examining mechanical force generation either necessitate dedicated

158 Today, overt or covert mechanical forces govern cell biological processes and p

159 Although mechanical forces have been characterized at the single

160 Mechanical forces have been proposed to modulate organ g

161 s a deliberate or an involuntary response to mechanical forces have been the subject of conflicting r

162 Mechanical forces have previously been used to drive rea

163 g bLVR are related to microscopic changes in mechanical force heterogeneity; and (3) both techniques

164 ime of FcgammaRIIA-IgG bonds increased under mechanical force in an F-actin-dependent manner, which c

165 ic nanoparticles as localized transducers of mechanical force in combination with pressure-clamp elec

166 Proteins fold under mechanical forces in a number of biological processes, r

167 al important developmental processes involve mechanical forces in an essential manner.

168 We hypothesized that mechanical forces in bacterial adhesion could regulate t

169 cal and molecular technologies, the roles of mechanical forces in cardiac biology are being explored

170 The importance of mechanical forces in influencing cell behaviour is widel

171 to enable the measurement of cell-generated mechanical forces in intact tissues in vivo, which will

172 biophysical assays, now supports a role for mechanical forces in not only modulating cell behavior b

173 The proteins sensing mechanical forces in podocytes are unconfirmed, but the

174 Recent studies suggest an important role of mechanical forces in regulating cellular behaviors.

175 Although the key role of mechanical forces in shaping plant architecture from the

176 new molecular-level insight into the role of mechanical forces in the assembly and function of GAG-ri

177 Mechanical forces in the cell's natural environment have

178 enges associated with accurately quantifying mechanical forces in the developing heart.

179 Blood flow and mechanical forces in the ventricle are implicated in car

180 tle knowledge on potential risks of applying mechanical forces in the vicinity of tumors.

181 Axons must withstand mechanical forces, including tension, torsion, and compr

182 as a powerful tool to monitor the extent of mechanical force-induced cartilage injury in vivo.

183 We found that mechanical force induces alpha-actinin-4 and actin accum

184 similar mechanical strength, likely because mechanical force induces the active state in wild-type F

185 mals spontaneously reduce fractures, yet the mechanical forces influencing this process are poorly un

186 tecture underscores the basis of translating mechanical force into an electrical signal within a cell

187 adhesion molecule-1 (PECAM-1), that convert mechanical force into biochemical signals.

188 Mechanosensation, the transduction of mechanical force into electrochemical signals, allows or

189 o develop synthetic materials that transduce mechanical force into multifold changes in their intrins

190 The transduction of mechanical force into useful chemical reactions is an em

191 The translation of mechanical forces into biochemical signals plays a centr

192 n has an important role in the conversion of mechanical forces into biochemical signals.

193 iezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critic

194 nt signalling as a candidate for transducing mechanical forces into joint cell behaviours.

195 Mechanical force is needed to mediate endocytosis.

196 The generation of acid under mechanical force is potentially useful for initiating pr

197 el cells or afferent fibres themselves sense mechanical force is still debated, and the molecular mec

198 f these channels and an understanding of how mechanical force is transduced has remained elusive.

199 losteric effects, chemical reagents, pH, and mechanical force, it is still challenging to introduce m

200 meter photon time-stamping spectroscopy with mechanical force manipulation, a newly developed single-

201 Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas st

202 such as extracellular regulators of ligands, mechanical forces, microRNAs and small molecule drugs as

203 chments is unknown, and the possibility that mechanical force might regulate centrosome function has

204 It has long been appreciated that mechanical forces must be applied to chromosomes.

205 ly, our findings suggest that a reduction of mechanical force near the boundary promotes Notch1-Dll4

206 important role in protecting tissues against mechanical force, no cytoplasmic IF proteins have been c

207 These data suggest that reduced spreading/mechanical force of fibroblasts in aged skin elevates PG

208 the ability of the nucleus to withstand the mechanical forces of the contracting heart.

209 lar junctions by which cells sense and exert mechanical force on each other.

210 and that this pathway is further enhanced by mechanical force on ICAM-1.

211 We propose that, by exerting mechanical forces on CPEB oligomers, an active cytoskele

212 ting spatiotemporally controlled subcellular mechanical forces on live cells by acoustic actuation of

213 perparamagnetic beads to tip links and exert mechanical forces on the links when exposed to a magneti

214 F-actin and microtubules are known to exert mechanical forces on the nuclear surface through molecul

215 Cells are physical objects that exert mechanical forces on their surroundings as they migrate

216 t amoeboid migration requires cells to apply mechanical forces on their surroundings via transient ad

217 al pore loops that effect the application of mechanical forces onto SPs to promote unfolding and tran

218 ustering, and is sustained in the absence of mechanical force or association with F-actin or vinculin

219 which ring motors convert chemical energy to mechanical force or torque and coordinate the activities

220 Mechanical force organizes life at all scales, from mole

221 Mechanical (force, peak power, mean power, velocity and

222 Cell-generated mechanical forces play a critical role during tissue mor

223 Mechanical forces play critical roles in collective cell

224 Mechanical forces play critical roles in the function of

225 Mechanical forces play increasingly recognized roles in

226 Mechanical forces play key roles in regulating cellular

227 fashion by changing the concentration or the mechanical force (pressure) applied.

228 Quantifying the mechanical forces produced by fluid flows within the oce

229 In support of this model, mechanical force production is compromised and cell prol

230 ontrol of pMLC levels, which is critical for mechanical force production, likely through the direct i

231 Mechanical force regulates a broad range of molecular in

232 vestigated the molecular mechanisms by which mechanical force regulates Ca(2+) signaling at endoplasm

233 The use of mechanical forces renders antigen extraction sensitive t

234 crotubules against each other, providing the mechanical force required for initial neurite extension

235 muscle contraction and the generation of the mechanical force required to pump blood.

236 te at gastrulation, but how the adhesive and mechanical forces required for these movements are gener

237 the actomyosin cytoskeleton in providing the mechanical forces required to remodel the lipid bilayer

238 Reduced spreading/mechanical force resulted in increased expression of bot

239 er, the mechanisms by which bone cells sense mechanical forces, resulting in increased mineral deposi

240 Activation of Piezo2 by mechanical forces results in a characteristic ionic curr

241 consistent with heightened activity of this mechanical force-sensitive system in atherosclerosis.

242 th usual interstitial pneumonia submitted to mechanical force showed an increase in TGF-beta1 activat

243 K(+) channel TRAAK (K2P4.1) is responsive to mechanical forces similar to the ion channel Piezo1 and

244 Bone turnover in vivo is regulated by mechanical forces such as shear stress originating from

245 proteins that are physiologically exposed to mechanical forces, such as cardiac titin.

246 This has been attributed to mechanical forces, such as urine flow, that prevent the

247 genetic perturbations, we show that passive mechanical forces suffice to explain the observed size c

248 laments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier

249 clustering that may allow the development of mechanical forces, sustained force is not required for m

250 resulting from insults caused by an external mechanical force that disrupts normal brain function, ha

251 alized embryos still gastrulate, producing a mechanical force that strains the developing skin along

252 mitting chemical energy from hydrolysis into mechanical force that translocates the substrate is stil

253 Ciliary beating produces asymmetric mechanical forces that are resisted by basal bodies.

254 odulation is dependent on the fine-tuning of mechanical forces that are transmitted in part through t

255 biochemical signaling interactions with the mechanical forces that eventually pattern and shape the

256 Actomyosin contraction generates mechanical forces that influence cell and tissue structu

257 in which the T cell actin network generates mechanical forces that regulate LFA-1 activity at the im

258 ctivity of kinetochore microtubules generate mechanical forces that segregate sister chromatids.

259 of a cell's ability to sense and respond to mechanical force, the molecular mechanisms by which phys

260 ation of the mechanosensors and the kinds of mechanical forces they can sense and respond to.

261 he most common hypothesis being sensation of mechanical force through calcium-permeable ion channels

262 Cells experience mechanical forces throughout their lifetimes.

263 witching can be attributed to intramolecular mechanical forces, thus laying the foundation for a new

264 e mechanisms that govern the conversion of a mechanical force to distinct patterns of action potentia

265 dies have revealed how Piezo1 protein senses mechanical force to enable vascular development.

266 Polymerized actin provides mechanical force to form endocytic pits.

267 as outer dynein arms (ODAs) develop the main mechanical force to generate the ciliary and flagellar b

268 we used a hydraulic apparatus that can apply mechanical force to intercellular junction in a confluen

269 0 degrees , was achieved by application of a mechanical force to its molecular monolayer at the air-w

270 kemia cells onto pre-activated ECs exerted a mechanical force to regain the cell surface contact whic

271 c functionalization can now be used to apply mechanical force to specific regions of cells, which per

272 with 40% of molecules requiring virtually no mechanical force to unfold (<10 piconewtons (pN)), sugge

273 ave a narrow pore and therefore must capture mechanical forces to control gating in another way.

274 cyte function and demonstrate that cells use mechanical forces to control the activity of outgoing ch

275 relies on tools that are capable of applying mechanical forces to elicit and assess cellular response

276 s have been characterized that control local mechanical forces to elongate epithelial tissues, genes

277 ryo development requires the coordination of mechanical forces to generate the macroscopic shapes of

278 We then apply mechanical forces to growing leaves after veins have dif

279 We have found that after applying mechanical forces to ICAM-1 clusters, there is an increa

280 al for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and

281 ves as a filter that buffers transmission of mechanical forces to nociceptor nerve endings thereby re

282 is driven by the increase and clustering of mechanical forces to push the centrosome toward the cell

283 Generating the mechanical forces to support motility are divergent clas

284 play an integral role in the transmission of mechanical forces to the central foveal cones.

285 d respond to intercellular and intracellular mechanical forces to transduce mechanical signals and ma

286 by the hot bubbles and mechanically by fluid mechanical forces to transiently increase cell membrane

287 n has been proposed to help axons resist the mechanical forces to which they are exposed (e.g., compr

288 Mechanical forces transduced to cells through the extrac

289 response to membrane tension as a result of mechanical force transmitted directly to the channel fro

290 Are mechanical forces transmitted directly from membrane to

291 and bone marrow cells were used to verify if mechanical force triggered IL-33 and ST2 expression as w

292 le proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times sc

293 These results suggest that mechanical forces via cell-matrix and cell-cell interact

294 these subunits in the channel's response to mechanical force, we expressed degenerin channels compri

295 Ductile materials can absorb spikes in mechanical force, whereas brittle ones fail catastrophic

296 e rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure

297 ed blood cells (RBCs) experience significant mechanical forces while recirculating, but the consequen

298 physiological conditions for cell adhesion, mechanical force will drive a nonequilibrium cycle that

299 Mechanical forces will have been omnipresent since the o

300 Mechanical force, with its ability to distort, bend, and