ライフサイエンスコーパス: mechanosensation

1 r membrane through processes referred to as "mechanosensation".

2 t formation is not simply caused by impaired mechanosensation.

3 brain injury, whereas ASIC2a is involved in mechanosensation.

4 ntral nervous system regions associated with mechanosensation.

5 nt defects in peripheral thermosensation and mechanosensation.

6 ave a function in noxious cold sensation and mechanosensation.

7 n viability, cell-to-cell communication, and mechanosensation.

8 ide variety of receptor cells, especially in mechanosensation.

9 the contribution of ASIC3 to nociception and mechanosensation.

10 t implications for mammalian nociception and mechanosensation.

11 family perform diverse functions, including mechanosensation.

12 le is known of molecular mechanisms of human mechanosensation.

13 nnel proteins in the process of gentle touch mechanosensation.

14 le is known about the molecular machinery of mechanosensation.

15 lity most tightly linked to motor control is mechanosensation.

16 of temperature to modify taste sensation and mechanosensation.

17 ated in touch sensitivity and other forms of mechanosensation.

18 hat PPK may be a channel subunit involved in mechanosensation.

19 hanism for innate defensive behavior through mechanosensation.

20 hysical properties and queried their role in mechanosensation.

21 vel way in which Merkel cells participate in mechanosensation.

22 worms that have defects in head movement or mechanosensation.

23 ironment, and therefore exhibits features of mechanosensation.

24 proximity, independent of genes required for mechanosensation.

25 hannel(s) must account for noxious (painful) mechanosensation.

26 in line with its proposed functional role in mechanosensation.

27 or currents, the initiating step of cellular mechanosensation.

28 nsor, implicating them directly in inner ear mechanosensation.

29 nt of the fly chordotonal organs and mediate mechanosensation.

30 ns, especially membrane proteins involved in mechanosensation.

31 CNQ4), which is involved in both hearing and mechanosensation.

32 ermine whether Piezo2 is involved in EC cell mechanosensation.

33 age-dependent ion channels to play a role in mechanosensation.

34 n, cell shape regulation, contractility, and mechanosensation.

35 ally found in the TRNs, is not essential for mechanosensation.

36 haviors of the myosin II accumulation during mechanosensation.

37 not required for sensory neuron survival or mechanosensation.

38 his active tension is essential for cellular mechanosensation.

39 ntify a role for integrin signaling genes in mechanosensation.

40 ith the myocardial Z-disk, playing a role in mechanosensation.

41 is important in metazoan cell migration and mechanosensation.

42 r TRP proteins simply play indirect roles in mechanosensation.

43 understanding how TRP channels contribute to mechanosensation.

44 odulate chemosensation, thermosensation, and mechanosensation.

45 rchetypal example in this regard is cellular mechanosensation, a process by which mechanical forces a

46 which is thought to be responsible for their mechanosensation ability, also spontaneously generating

47 genetic and molecular dissection of auditory mechanosensation and auditory behavior.

48 esulting in behavior defects associated with mechanosensation and chemosensation.

49 annel that plays a major role in light-touch mechanosensation and has recently been identified as the

50 amine P2X(3) receptor contributions to colon mechanosensation and hypersensitivity, electrophysiologi

51 e Caenorhabditis elegans are central to both mechanosensation and locomotion.

52 Impaired mechanosensation and mechanotransduction associated with

53 echanism by which opioids modulate cutaneous mechanosensation and provide a rationale for targeting D

54 expressed in the inhibitory pathway linking mechanosensation and pumping activity.

55 n the cilium, cell-cycle, and cilia-mediated mechanosensation and signaling activity will hopefully p

56 g concepts in podocyte biology, particularly mechanosensation and signaling at the slit diaphragm.

57 to ion channel activity, a prerequisite for mechanosensation and the integrity of the kidney filtrat

58 of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception.

59 duction, including olfaction, osmosensation, mechanosensation, and chemosensation.

60 TAT is important in neuronal polarity and mechanosensation, and decreased tubulin acetylation leve

61 y accelerated reinnervation, the recovery of mechanosensation, and epithelial wound healing.

62 regulation, nociception, neuronal function, mechanosensation, and even defaecation.

63 to socially aggregate [3, 4] and use vision, mechanosensation, and gustation to recognize each other

64 physiological processes such as nociception, mechanosensation, and learning-memory, and in the pathol

65 ons of ASICs in mammals include nociception, mechanosensation, and modulation of synaptic transmissio

66 pore domain (K2P) K(+) channel important for mechanosensation, and recent studies have shown how incr

67 ogical friction, we propose a model for cell mechanosensation as opposed to previous more biochemical

68 mplexes involved in structural integrity and mechanosensation, as well as cell signaling.

69 TRP family channels have been implicated in mechanosensation, but none have been demonstrated to for

70 ortant physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeo

71 ophysiological activity, resulting in larval mechanosensation defects.

72 we uncovered a central role for kinocilia in mechanosensation during development.

73 s acts as a mechanostat to modulate cellular mechanosensation during differentiation.

74 orchestrated cellular behaviors required for mechanosensation, embryogenesis, and physiological contr

75 tallisation, has provided a new paradigm for mechanosensation, enabling a deeper understanding of the

76 Aberrant mechanosensation has an important role in different pain

77 ng molecules and wiring patterns involved in mechanosensation has been dramatic over the past few yea

78 Mechanosensation has been studied for decades, but under

79 Among sensory modalities, mechanosensation has been the most elusive with regard t

80 logenetic framework, we show that peripheral mechanosensation has evolved with limb biomechanics, evo

81 Molecules required for mechanosensation have been identified from invertebrate

82 a number of intriguing mutants defective in mechanosensation have recently been described.

83 s of sensory perception, thermosensation and mechanosensation, highlighting pathways whose perturbati

84 We conclude that mechanosensation, if it originates in primary cilia, is

85 ealistic membrane models for the analysis of mechanosensation in a continuum mechanics framework.

86 ave yielded fundamental insights relevant to mechanosensation in all animals, and also to point out h

87 , several of which have been associated with mechanosensation in animals.

88 In order to demonstrate mechanosensation in artificial cells, we develop a novel

89 sion could explain cell tension response and mechanosensation in different environments.

90 annel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in

91 e use of Yvc1p as a molecular model to study mechanosensation in general is discussed.

92 results show that PIEZO2 is a determinant of mechanosensation in humans.

93 Here, we review our current understanding of mechanosensation in insects and its role in adaptive mot

94 While the ubiquity of mechanosensation in living cells is evident, the ion cha

95 Piezo channels have a physiological role in mechanosensation in mammals.

96 Mechanosensation in many organs (e.g. lungs, heart, gut)

97 by mechanical tension are thought to mediate mechanosensation in many systems.

98 as been shown to be essential for aspects of mechanosensation in model organisms.

99 iquitous and diverse, the molecular bases of mechanosensation in most cases remain mysterious MscL, a

100 rimary cilia function may also shed light on mechanosensation in other organ systems.

101 uding insulin-stimulated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, tra

102 Their role in mechanosensation in the animal kingdom, identified by ge

103 ASICs have also been implicated in mechanosensation in the peripheral nervous system and in

104 dout of polycystin function and that loss of mechanosensation in the renal tubular epithelia is a fea

105 been suggested to contribute to thermal and mechanosensation in the tooth via expression of transien

106 els, which together are necessary for normal mechanosensation in the worm.

107 tudies have shown the importance of antennal mechanosensation in various aspects of insect flight con

108 th muscle cell differentiation, adhesion and mechanosensation in vitro.

109 Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels.

110 These findings support a model of mechanosensation in which the activities of Abeta-, Adel

111 d system in fact broadly regulates cutaneous mechanosensation, including touch.

112 licated in varied biologic functions such as mechanosensation, ion homeostasis, cell growth, and phos

113 Mechanosensation is a primitive and somewhat ubiquitous

114 Mechanosensation is emerging as a general principle of m

115 In bacteria, mechanosensation is mediated by the mechanosensitive cha

116 Mechanosensation is perhaps the last sensory modality no

117 ted in perception of pain, ischaemic stroke, mechanosensation, learning and memory.

118 s the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechano

119 licit changes in adhesion complex stability, mechanosensation, matrix assembly, and migration, but th

120 Although previous data indicated that mechanosensation might contribute to hygrosensation, the

121 d spinal cord and a significant reduction in mechanosensation occurs before detectable fibrillar tau

122 and cell-cycle-stage-specific control of the mechanosensation of myosin IIB, but not myosin IIA or II

123 anization (centrosomal function) but also in mechanosensation of urine flow (a primary ciliary functi

124 cyte to the microvasculature, and astrocytic mechanosensation of vascular changes.

125 nd distribution emphasizes the importance of mechanosensation on osteoblastic cell function in a 3D e

126 Mechanosensation, one of the fastest sensory modalities,

127 This flow-induced ciliary mechanosensation opens the calcium (Ca(2+)) channel poly

128 impaired thermoregulation but did not impair mechanosensation or beta-alanine itch-stimuli associated

129 approach devoid of unwanted abnormalities in mechanosensation or pain perception.

130 e direction of flow is sensed either through mechanosensation, or via the detection of chemical signa

131 elegans TRPV channels function in olfaction, mechanosensation, osmosensation, and activity-dependent

132 cently identified, but mechanisms underlying mechanosensation, particularly in vertebrate organisms,

133 portunity to discern the respective roles of mechanosensation (perception and proprioception) and mec

134 well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in

135 cross-linking proteins observed in cellular mechanosensation, provided that a similar mechanism oper

136 tential (TRP) channel NOMPC is important for mechanosensation-related behaviours such as locomotion,

137 The functional role of the polycystins in mechanosensation remains largely unknown.

138 Mechanosensation requires the transduction of mechanical

139 ring development, liquid flow in the kidney, mechanosensation, sight, and smell.

140 TMCs bind other proteins essential for mechanosensation, suggesting a larger transduction compl

141 pathological processes such as nociception, mechanosensation, synaptic plasticity, and acidosis-medi

142 a touch-transducing ion channel critical for mechanosensation that when hyperactivated by a mec-4(d)

143 Mechanosensation, the ability to detect mechanical force

144 ous proteins, are thought to be important in mechanosensation, the process by which the cell senses a

145 Mechanosensation, the transduction of mechanical force i

146 Mechanosensation, the transduction of mechanical forces

147 eral genes encoding channels associated with mechanosensation, thermosensing or water transport.

148 have become the current structural models of mechanosensation to atomic detail.

149 ic screens that allowed molecules needed for mechanosensation to be identified without any prior unde

150 The sensing of physical force, mechanosensation, underlies two of five human senses-tou

151 that Merkel cells have a role in vertebrate mechanosensation using Piezo2, particularly in shaping t

152 The mechanosensation via receptor unfolding may be applicabl