ライフサイエンスコーパス: mer

1 agent for Middle East respiratory syndrome (MERS).

2 extending the analyte recognition beyond a 5-mer.

3 crystal formed by self-assembly of a DNA 13-mer.

4 ags behind beta7 incorporation into the half-mer.

5 al-reproductive tyrosine kinase; ie, soluble MER), a critical biomarker of compromised phagocytosis b

6 Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibro

7 ex formation is observed for homo-sequence 2-mers (AA.DD) where there are no competing folding equili

8 In silico analysis indicated that this 49-mer Aalpha-chain peptide contained a motif (VLITL), with

9 Additionally, POLRMT+TFB2M makes 2-mer abortives on LSP, but longer RNAs are observed only

10 ifferent SNP pipelines, wgMLST approaches, k-mer algorithms, whole genome alignment and others; each

11 with different classification strategies (k-mer, alignment, marker) can combine their respective adv

12 The corresponding hetero-sequence AD 2-mers also form duplexes, but the observed self-associati

13 verage existing approaches already used in k-mer analysis to identify enriched motifs.

14 two maize inbred lines B73 and Mo17 using k-mer analysis to quantify the differences between the two

15 We present the K-mer Analysis Toolkit (KAT): a multi-purpose software too

16 ation kinetics beyond probes longer than a 6-mer and proceeded fastest for a 5-mer PNA probe.

17 to study the functional correlation between Mer and TLRs in the development of GC responses and auto

18 Two different assembly states (36-mers and 32-mers) coexist as well as occasional extended

19 We first split DNA sequences into k -mers and pre-train k -mer embedding vectors based on the

20 The recent outbreaks of MERS and previous emerging infections provide valuable l

21 can be uniquely described by overlapping 31-mers and show how rapid and accurate SNP and indel genot

22 ct matches between short sequence strings (k-mers) and an MLST allele library.

23 mmetry axis (lel/ob), geometric isomers (fac/mer), and configurational diastereomers (R/S) arising fr

24 monstrated by using a previously reported 35-mer aptamer for a small molecule, 17beta-estradiol.

25 al binding between l-tyrosinamide and its 49-mer aptamer for which neither structural nor mechanistic

26 The MERs are for segmenting each single cell in the populati

27 has undesirable behaviors (e.g. too many k -mers are selected when processing certain sequences).

28 This indicates that conventional GlcNAc-mers are unlikely to be produced and/or accumulate in P.

29 aggregates up to the size of at least the 13-mer as well as partially folded beta-sheet containing ol

30 DNA sequence from E. coli O157:H7 having 22 mers as an amine-terminated probe ssDNA was immobilized

31 we used an alignment-free method that uses k-mers as genomic features for a large-scale comparison of

32 e introduce a novel approach that clusters k-mers as the first step.

33 (SARS) and Middle East respiratory syndrome (MERS), as well as a number of important animal pathogens

34 produced fewer chimeras across all single k-mer assemblies.

35 creases in abundance of additional sets of k-mers associated with centromere, 45S rDNA, knob, and ret

36 Recently developed state-of-the-art k-mer based alignment-free dissimilarity measures includin

37 M also provides additional advanced gapped k-mer based kernel functions.

38 A k-mer based method provides greater taxonomic accuracy tha

39 While k-mer based methods are predominantly used in real applica

40 This kernel extends an existing class of k-mer based sequence kernels, based on the recently descri

41 Sasquatch performs a comprehensive k-mer-based analysis of DNase footprints to determine any

42 The DNA 13-mer, BET66, self-assembles via Crick-Watson and noncanon

43 (as high as m/z 2793 corresponding to the 26-mer), but a significant abundance of thermolysis product

44 tors based on the co-occurrence matrix of k -mers by using an unsupervised representation learning ap

45 ggregates all misclassification error rates (MER) by taking cell sizes as weights.

46 in the analogous complex with a pincer-type mer-C,N,S ligation, emphasizing the importance of the fa

47 tion under defined thermodynamic conditions, MER can also be used to capture changes in iron oxide re

48 demic period and sex on the fatality rate of MERS cases and its variation across countries.

49 Further, since many MERS cases are acquired in healthcare settings, public h

50 Lack of autopsies from MERS cases has hindered understanding of MERS-CoV pathog

51 The crude fatality rate of MERS cases was 32.1% (95% credibility interval (CI): 29.

52 outcome of Middle East respiratory syndrome (MERS) cases up to the end of October 2016.

53 a to improve both subsystem annotation and k-mer classification, and tags new genomes as having signa

54 mprehensive framework to integrate useful k -mer co-occurrence information with recent advances in de

55 wo different assembly states (36-mers and 32-mers) coexist as well as occasional extended forms with

56 roach to this task is to model the typical k-mer composition of a set of CRMs known to drive a common

57 pattern to other CRMs exhibiting a similar k-mer composition.

58 Meridional (mer) coordination promotes the generation of larger and

59 ddle East respiratory syndrome and was named MERS coronavirus (MERS-CoV).

60 S)-CoV and Middle East respiratory syndrome (MERS)-CoV, cause severe and lethal human disease.

61 d both vaccinated mice and control mice with MERS-CoV after adenovirus transduction of the human dipe

62 As a result, the interface of MERS-CoV and human interferon-stimulated gene product 15

63 the significantly lower MERS-CoV titers and MERS-CoV and mRNA levels in challenged mice than those i

64 derstanding viral deISGylase activity within MERS-CoV and other CoVs.IMPORTANCE Coronaviruses, such a

65 uch as camels, as well as humans from deadly MERS-CoV and RABV infections.

66 otein induce potent immune responses against MERS-CoV and RABV.

67 uces a new tool to probe the pathogenesis of MERS-CoV and related viruses through the removal of vira

68 Nine camel workers with MERS-CoV antibodies and 43 workers without antibodies we

69 No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney.

70 We now demonstrate that in addition to DPP4, MERS-CoV binds to sialic acid (Sia).

71 MERS-CoV can infect multiple host species and cause seve

72 However, in vivo studies are limited because MERS-CoV cannot infect wild-type mice due to incompatibi

73 World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for

74 accinated mice were fully protected from the MERS-CoV challenge, as indicated by the significantly lo

75 MERS-CoV has been hampered by the fact that MERS-CoV does not replicate in commonly available mouse

76 As part of its viral genome, MERS-CoV encodes a papain-like protease (PLpro) that has

77 ace Sia by neuraminidase treatment inhibited MERS-CoV entry of Calu-3 human airway cells, thus provid

78 and between humans means that the drivers of MERS-CoV epidemics remain poorly characterized.

79 There are no treatment options against MERS-CoV for humans or animals, and there are no large-s

80 Although MERS-CoV generally causes subclinical or mild disease, i

81 Therefore, development of mouse models of MERS-CoV has been hampered by the fact that MERS-CoV doe

82 While the cell surface receptor for MERS-CoV has been identified as dipeptidyl peptidase 4 (

83 DPP4 species-specific differences impacting MERS-CoV host range and better inform our understanding

84 aling species-specific differences impacting MERS-CoV host range.

85 e first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital o

86 MERS-CoV infection during pregnancy may be associated wi

87 These mutations severely compromised MERS-CoV infection into human lung-derived cells, but ha

88 Treatment of SARS-CoV and MERS-CoV infection is limited to providing supportive th

89 mouse model to analyze the host response to MERS-CoV infection using immunological assays and transc

90 related activities may pose a higher risk of MERS-CoV infection, as may cross-border movements of cam

91 While bat, camel, and human DPP4 support MERS-CoV infection, several DPP4 orthologs, including mo

92 then analyzed the ability of mice to control MERS-CoV infection.

93 ation of mouse DPP4 plays a role in blocking MERS-CoV infection.

94 pectrum RBD-based subunit vaccine to prevent MERS-CoV infection.

95 glycosylation site that acts as a barrier to MERS-CoV infection.

96 ansmission occurring during the treatment of MERS-CoV infections imported to Thailand.

97 on prevention and control measures for human MERS-CoV infections.

98 emergence and host susceptibility.IMPORTANCE MERS-CoV is a recently emerged zoonotic virus that is st

99 for use in animals and humans in areas where MERS-CoV is endemic.

100 for highly pathogenic coronaviruses, even as MERS-CoV is spreading throughout the Middle East.

101 Since RBD mutations occur in different MERS-CoV isolates and antibody escape mutants, cross-neu

102 Our results indicate that MERS-CoV maintains the ability to replicate in bats with

103 coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusi

104 during the 2012-2015 outbreaks, 5 MAb escape MERS-CoV mutants, and 2 live human MERS-CoV strains.

105 MERS-CoV strains, as well as antibody escape MERS-CoV mutants.

106 ll shape the capacity to prevent and control MERS-CoV or new emerging disease transmission.

107 The MERS-CoV outbreak began in Saudi Arabia and has spread t

108 for the inflammatory response in regulating MERS-CoV pathogenesis in vivo The Middle East respirator

109 lable vaccines or therapeutics, the study of MERS-CoV pathogenesis is crucial for its control and pre

110 rom MERS cases has hindered understanding of MERS-CoV pathogenesis.

111 Here, biophysical techniques revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C

112 Although the overall impact of MERS-CoV PLpro function is observed to be essential, dif

113 The first structure of MERS-CoV PLpro in complex with this domain exposed the i

114 Subsequently, the structure of MERS-CoV PLpro was solved to 2.4 A in complex with the C

115 % fatalities and now spread to 27 countries, MERS-CoV poses a significant ongoing threat to global hu

116 The emergence of SARS-CoV and MERS-CoV provides evidence that coronaviruses are curren

117 Therefore, this study demonstrates that MERS-CoV RBD is an important vaccine target able to indu

118 icted to infection at the level of DPP4, the MERS-CoV receptor, we generated mice with humanized exon

119 (+) T cells, or macrophages has no effect on MERS-CoV replication in the lungs of infected mice.

120 2,3-linked Sias and the predominant sites of MERS-CoV replication in the upper and lower respiratory

121 bl2), as required for efficient SARS-CoV and MERS-CoV replication in vitro These data demonstrate tha

122 d high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directe

123 only low-level incorporation of full-length MERS-CoV S into RABV particles.

124 that contained the MERS-CoV S1 domain of the MERS-CoV S protein fused to the RABV G protein C terminu

125 BNSP333-S, expresses a full-length wild-type MERS-CoV S protein; however, it showed significantly red

126 eloped a RABV-MERS vector that contained the MERS-CoV S1 domain of the MERS-CoV S protein fused to th

127 ental vaccine vector BNSP333, and the RABV G-MERS-CoV S1 fusion protein was efficiently expressed and

128 ivated rabies virus particles containing the MERS-CoV S1 protein induce potent immune responses again

129 rol studies to assess risk factors for human MERS-CoV seropositivity at a farm complex in Qatar.

130 ay with human erythrocytes and intact virus, MERS-CoV Sia-binding activity was assigned to S subdomai

131 ivated rabies virus (RABV) that contains the MERS-CoV spike (S) protein expressed on its surface.

132 e mutants, cross-neutralization of divergent MERS-CoV strains by RBD-induced antibodies remains unkno

133 in the RBD of representative human and camel MERS-CoV strains during the 2012-2015 outbreaks.

134 e mutations detected in representative human MERS-CoV strains from the 2012, 2013, 2014, and 2015 out

135 S proteins of representative human and camel MERS-CoV strains identified during the 2012-2015 outbrea

136 infection by divergent pseudotyped and live MERS-CoV strains, as well as antibody escape MERS-CoV mu

137 Ab escape MERS-CoV mutants, and 2 live human MERS-CoV strains.

138 ion by divergent circulating human and camel MERS-CoV strains.

139 vaccines against circulating human and camel MERS-CoV strains.

140 ein with multiple changes derived from camel MERS-CoV strains.

141 in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence vari

142 nge, as indicated by the significantly lower MERS-CoV titers and MERS-CoV and mRNA levels in challeng

143 high-specificity, low-affinity attachment of MERS-CoV to sialoglycans during the preattachment or ear

144 ns designated S1(A) through S1(D) Binding of MERS-CoV to the cell surface entry receptor dipeptidyl p

145 tract tissues of humans and camels reflects MERS-CoV tropism.

146 MERS-CoV was first identified in June 2012 and has since

147 By understanding the immune response to MERS-CoV we can develop targeted therapies to inhibit pa

148 pulmonary manifestations when infected with MERS-CoV would advance the field.

149 e East respiratory syndrome betacoronavirus (MERS-CoV) and found that 11 of the 22 residues in the pF

150 iddle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipeptidyl peptidas

151 iddle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease.

152 iddle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is a highly pathogenic res

153 iddle East respiratory syndrome coronavirus (MERS-CoV) encode multifunctional papain-like proteases (

154 iddle East respiratory syndrome coronavirus (MERS-CoV) has been attributed to overcrowding, delayed d

155 iddle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and drome

156 iddle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoron

157 iddle East respiratory syndrome coronavirus (MERS-CoV) infection have been reported worldwide, with 6

158 iddle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown.

159 iddle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that

160 iddle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its

161 iddle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in 2012, causing

162 iddle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen that is the caus

163 iddle East respiratory syndrome coronavirus (MERS-CoV) is an important emerging pathogen that was fir

164 iddle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respirator

165 iddle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an e

166 e of AgNPs, giving detection limits of 1.53 (MERS-CoV), 1.27 (MTB), and 1.03 nM (HPV).

167 iddle East respiratory syndrome coronavirus (MERS-CoV), and human CoV 229E (HCoV-229E).

168 iddle East respiratory syndrome coronavirus (MERS-CoV), encode a papain-like protease (PLpro) that po

169 iddle East respiratory syndrome coronavirus (MERS-CoV), Mycobacterium tuberculosis (MTB), and human p

170 respiratory syndrome-associated coronavirus (MERS-CoV).

171 ory syndrome and was named MERS coronavirus (MERS-CoV).

172 V) and Middle East respiratory syndrome CoV (MERS-CoV).

173 iddle East respiratory syndrome coronavirus (MERS-CoV).

174 erefore, the activity of PLPs from SARS-CoV, MERS-CoV, and mouse hepatitis virus was evaluated agains

175 coronavirus, mouse hepatitis virus (MHV) and MERS-CoV, encode 2',5'-phosphodiesterases (2',5'-PDEs) t

176 Upon inoculation with MERS-CoV, human DPP4 knockin (KI) mice supported virus r

177 Relative to the parental MERS-CoV, MERSMA viruses contained 13-22 mutations, incl

178 cts and depletion of macrophages exacerbates MERS-CoV-induced pathology and clinical symptoms of dise

179 epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 tr

180 -scale clinical trials for therapies against MERS-CoV.

181 it high neutralizing antibody titers against MERS-CoV.

182 pothesis of bats as ancestral reservoirs for MERS-CoV.

183 p, we inoculated 10 Jamaican fruit bats with MERS-CoV.

184 r ability to act as functional receptors for MERS-CoV.

185 To study the impact of Mer deficiency on the development of autoimmunity, we ge

186 We previously showed that Mer-deficient mice (Mer(-/-)) have increased germinal ce

187 reference-free methods based primarily on k-mer distributions or coverage information, the proposed

188 uminescence increase in the presence of a 27-mer DNA duplex containing a central CC mismatch.

189 Fluorescence titrations with the 27-mer duplex containing the CC mismatch reveal a DNA bindi

190 Incubation of 135-mer duplexes with single Sp or Gh lesions in human cell

191 We show that k -mer embedding can effectively enhance model performance

192 DNA sequences into k -mers and pre-train k -mer embedding vectors based on the co-occurrence matrix

193 ong Short-Term Memory (LSTM) network with k -mer embedding.

194 The Middle East respiratory syndrome (MERS) emerged in Saudi Arabia in 2012, caused by a zoono

195 Mer executes its function by stabilizing adherens juncti

196 as associated with loss of tubular Tyro3 and Mer expression in diabetic nephropathy tissue and glomer

197 Recently, TYRO3, a member of the TYRO3-AXL-MER family of receptor tyrosine kinases, was identified

198 nto two classes: one based on handcrafted k -mer features and the other based on convolutional neural

199 with Abeta pentamer (oligomer model) and 16-mer (fibril model).

200 onstrated the essentiality of a conserved 16-mer for mRNA stability.

201 specifically near the mismatch site on a 27-mer fragment, consistent with mismatch targeting.

202 ovo genome assemblies, primarily via their k-mer frequencies and GC composition.

203 rained with general features such as multi k-mer frequencies and relaxed open reading frames.

204 xpensive than measures based solely on the k-mer frequencies.

205 r taxonomic assignments, or use nucleotide k-mer frequency as the proxy for sequence similarity measu

206 and calculates four different statistics: k -mer frequency, 16S abundance, prokaryotic- and viral-rea

207 of UvrD in vivo is to unwind the excised 13-mer from dsDNA and that mutation of uvrD results in rema

208 ry possible L-long sequence must contain a k-mer from the set.

209 nimizers scheme is a method for selecting k -mers from sequences.

210 We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately ups

211 e previously showed that Mer-deficient mice (Mer(-/-)) have increased germinal center (GC) responses,

212 TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity.

213 compared with B6.Sle1b mice, indicating that Mer immunoregulatory signaling in APCs regulates B cell

214 lower levels of the cleavage product soluble Mer, improved efferocytosis, smaller necrotic cores, thi

215 Given the known role of Mer in contact-dependent inhibition of proliferation, we

216 ctly affect GC B cell responses, the loss of Mer in dendritic cells promotes enhanced T cell activati

217 Mer is constitutively expressed in the glomeruli; Axl ex

218 integers k and L > k, we say that a set of k-mers is a universal hitting set (UHS) if every possible

219 293A cells transiently transfected with mER isoforms were used to detect EDC-mediated changes in

220 milarity over distributions of their short k-mers (k = 3-4) along the sequences.

221 A hash table of junction k-mers (k-mers spanning branching structures in the de Bru

222 i-mismatch kernel performs better than the k-mer kernel, for larger k; and (iii) the di-mismatch + sh

223 Mer-KO mice developed severe glomerulonephritis, with si

224 Conventional peptides in the 20-40-mer length range are rapidly degraded by proteases, whic

225 vely compared 11 ONF metrics using several k-mer lengths for predicting host taxonomy from among appr

226 infiltration into the heart reduced soluble MER levels post-ischemia reperfusion.

227 tivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route.

228 e suggested as another natural reservoir for MERS-like-CoVs.

229 revealed by a small fraction of bona-fide 14-mers (<4%) that may enable subunit exchange.

230 the assumed infectivity of each patient with MERS may be appropriate.

231 In this study, we generated Mer(-/-) mice with a global MyD88, TLR7, or TLR9 deficie

232 lated in GCs drives enhanced GC responses in Mer(-/-) mice.

233 We also show that an 80-mer minicircle DNA using the same TG-motifs faithfully r

234 idney cells had down-regulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer.

235 Mer mutant CySCs fail to coordinate their proliferation

236 rticular, DOCKS uses less than 30% of the 10-mers needed to span the human genome compared to minimiz

237 ation, i.e. the number of times that each k -mer occurs, which is key in transcriptome assemblers.

238 receptor by assembling monomers into 6- to 8-mer oligomers; condensation of the preassembled oligomer

239 MethylBreak (MB) is a 22-mer oligonucleotide with one hemimethylated and two unme

240 R spectroscopy, excludes the intermediacy of mer-(ONO(Q))Re(V)O2(IMes) in this oxygen atom transfer r

241 ide an in-depth analysis of the effect of k -mer ordering on the performance of the minimizers techni

242 With MERS outbreaks resulting in over 35% fatalities and now

243 n control are required to prevent additional MERS outbreaks.

244 number of Middle East respiratory syndrome (MERS) outbreaks have been linked to healthcare facilitie

245 After adjusting for age, epidemic period, MERS patients with comorbidity had around 4 times the ri

246 abolome resulted in the purification of a 22-mer peptaibol, gichigamin A (1).

247 We have previously reported that an 11-mer peptide (SAPP) derived from Streptococcus cristatus

248 We show that a 49-mer peptide derived from the C-terminal part of the Phe5

249 body was used to isolate mimotopes from a 12-mer peptide library in successive selection rounds.

250 threonine-468 of a CB1R distal C-terminus 14-mer peptide reduced CB1R-CRIP1a association.

251 interactions between Fn and each of eight 20-mer peptide variants containing amino acids Ala, Asn, Gl

252 of ArcA, which led to the discovery of an 11-mer peptide with the native sequence of ArcA that repres

253 This 18-mer peptide, which lies in Subdomain IIIA of human serum

254 The top 1% scoring 9- and 10-mer peptides (N = 97, total) were synthesized and tested

255 ico the 41 highest-affinity, A2-binding 8-11-mer peptides and assessed their binding, kinetic complex

256 d 3 NS1 using an Ag microarray tiled with 20-mer peptides overlapping by 15 aa and identified five re

257 , however, Mamu-A2*05 preferentially binds 8-mer peptides.

258 cross-beta-sheet self-association of the 49-mer Phe521Leufs peptide identified in vivo, whereas its

259 es reveal that removing the Ubl2 domain from MERS PLpro has no effect on its ability to process the v

260 s not required for the catalytic function of MERS PLpro in vitro.

261 We conclude that the catalytic core of MERS PLpro, i.e. without the Ubl2 domain, is sufficient

262 The X-ray structure of MERS PLpro-Ubl2 was determined to 1.9 A and compared to

263 r than a 6-mer and proceeded fastest for a 5-mer PNA probe.

264 assemblies through pairwise comparison of k-mers present in both input reads and the assemblies.

265 by PacBio or Oxford Nanopore), efficient k -mer processing is still crucial for accurate assembly, a

266 nscripts based on the gene fingerprint (as k-mers) profiles of the RNA-Seq paired-end reads.

267 eutralizing antibodies cross-neutralizing 17 MERS pseudoviruses expressing S proteins of representati

268 inase-1, and interleukin-10 by activation of mer receptor tyrosine kinase associated with inhibition

269 phagocytic and immunomodulatory functions of Mer regulate GC responses to prevent the development of

270 any changes in the structure of an Hsp27 12-mer, representative of larger Hsp27 oligomers.

271 ing platform involves immobilization of a 40-mer RNA probe specific for a characteristic fragment of

272 hese data establish that an inactivated RABV-MERS S-based vaccine may be effective for use in animals

273 lysis of DNase footprints to determine any k-mer's potential for protein binding in a specific cell t

274 This mer-selective self-assembly could be used to prepare tet

275 s analyse the complete set of read-derived k-mer sequence at once, resulting in the need for computer

276 cribed ES, as well as conserved VSG 3'UTR 16-mer sequences for the generation of functional levels of

277 mistry was used to synthesize all possible 3-mer sequences: AAA, AAD, ADA, DAA, ADD, DAD, DDA, and DD

278 Mer tyrosine kinase (Mer) signaling maintains immune tolerance by clearing ap

279 lies using eight programs with a series of k-mer sizes (from 25 to 71), including BinPacker, Bridger,

280 autoimmune-prone B6.Sle1b mice deficient in Mer (Sle1bMer(-/-)).

281 A hash table of junction k-mers (k-mers spanning branching structures in the de Bruijn grap

282 The TAM (Tyro3, Axl, Mer) subfamily of RTKs in particular feature in a variet

283 kinase family consisting of Tyro3, Axl, and Mer (TAM) is one of the most recently identified recepto

284 (CI) of TER are computed based on the SE of MER that is calculated using the bootstrap method.

285 stitution matrix and the maximum length of k-mers that it includes.

286 No therapeutics or vaccines are approved for MERS; thus, development of novel therapies is needed.

287 we used mediated electrochemical reduction (MER) to directly quantify the extents and rates of ferri

288 attempt to map sequence-level features ( k -mers) to binding event but usually ignore the location o

289 t in the detection of HRGPs using multiple-k-mer transcriptome assembly methodology was observed.

290 Mer tyrosine kinase (Mer) signaling maintains immune tol

291 e of the macrophage efferocytosis receptor c-Mer tyrosine kinase (MerTK) reduces efferocytosis and pr

292 ons and synapses via the phagocytic receptor Mer tyrosine kinase (MerTK).

293 ecruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic c

294 tact between MPhi and dying cancer cells via Mer tyrosine kinase.

295 and the natural lexicographic ordering of k -mers used by minimizers was recognized as their origin.

296 lly supported by the pairwise comparisons of MERs using 106 manually segmented ground-truth cells wit

297 sing concerns over the efficacy of RBD-based MERS vaccines against circulating human and camel MERS-C

298 Therefore, we developed a RABV-MERS vector that contained the MERS-CoV S1 domain of the

299 The B73 and Mo17 polymorphic k-mers were used to examine allele-specific expression of

300 event but usually ignore the location of k -mers, which can cause data fragmentation and consequentl