ライフサイエンスコーパス: methylation

1 s were significantly associated with low H19 methylation.

2 by attenuating the effect of local arginine methylation.

3 H mutations); and 1 patient had somatic MLH1 methylation.

4 ially sensitive region with mostly decreased methylation.

5 rous splicing factors, microRNAs and m6A RNA methylation.

6 Silencing did not require H3K9me3 or DNA methylation.

7 d patterns based on anonymous markers of DNA methylation.

8 f gene expression regulated, in part, by DNA methylation.

9 sequence variation on proximal CpG site DNA methylation.

10 cide, nor on epigenetic changes, such as DNA methylation.

11 MPO and PRTN3 expression correlated with DNA methylation.

12 lectrochemical sensing and biosensing of DNA methylation.

13 espread redistribution of repressive histone methylation.

14 ide RNAs does not increase the efficiency of methylation.

15 HPV-negative HNSCCs driven by aberrant H3K36 methylation.

16 MLH1 [including one with constitutional MLH1 methylation]; 16, MSH2; 1, MSH2/monoallelic MUTYH; 2, MS

17 is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), range

18 mononuclear cells (PBMCs) using the Infinium Methylation 450K array.

19 DNA methylation, a major epigenetic mark, was investigated u

20 DNA methylation aberrations have been implicated in acquired

21 Through a genome-wide analysis of DNA methylation across 19 cell types with T-47D as reference

22 roles in disease development, thus averaging methylation across RE may lose significant biological in

23 to cause a dominant negative loss of DNMT3A methylation activity, but 15% of DNMT3A mutations are pr

24 P = 0.50), but the presence of TERT promoter methylation, alone or concurrent with promoter mutations

25 DNA methylation alterations are hallmarks of CRC, and epigen

26 Future studies need to explore whether DNA methylation alterations influence the risk of AD-ND code

27 Variation in DNA methylation, an epigenetic mechanism, is implicated in b

28 Additional epigenome-wide methylation analyses using whole blood highlighted 36 di

29 a statistical approach for differential RNA methylation analysis with count-based small-sample seque

30 porating purity information for differential methylation analysis.

31 l TBT exposure induces global changes in DNA methylation and altered expression of metabolism-relevan

32 in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers and ne

33 ies have shown the relationship between WIF1 methylation and CS.

34 azacytidine-treated patients lacked aberrant methylation and DNMTi treatment of primary MDS stroma en

35 ficant negative correlation between promoter methylation and expression of an alternative transcripti

36 In conclusion, alterations in methylation and expression of genes involved in the regu

37 showed a significant association between DNA methylation and gene expression changes were PYGM, which

38 train to examine the genome-wide nuclear DNA methylation and gene expression patterns of brain tissue

39 ia characterized by interactions between DNA methylation and gene regulation mechanisms.

40 c effects of perinatal LPD on both Npy1r DNA-methylation and gene transcription.

41 We characterize genome-wide methylation and highlight conserved motifs across three

42 studies relied on the identification of DNA methylation and histone modifications at specific genes.

43 Alongside DNA methylation and histone modifications, bromodomain and e

44 s of the method by inferring allele-specific methylation and nucleosome occupancy in cell lines, and

45 ion, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a.

46 genome-wide analysis of gene expression, DNA methylation and small RNAs in the rice endosperm and fun

47 amming, by comparing genome-wide patterns of methylation and variation at the DNA level in hatchery-r

48 are known to affect TF binding (such as DNA methylation) and providing increased specificity as comp

49 ific genetic changes to gene expression, DNA methylation, and histone marks but these investigations

50 onfiguration of chromatin accessibility, DNA methylation, and mRNA expression to induce a default neu

51 enetic processes, such as alterations in DNA methylation, and perhaps through alterations in the gut

52 nal differentiation marker FoxA1 by promoter-methylation, and that is regulated by the Plk1 phosphory

53 at influences non-coding RNA production, DNA methylation, and transcriptional silencing.

54 s associations among air pollution exposure, methylation, and transcriptomic patterns.

55 the initiating events that lead to gene body methylation are discussed as a model illustrating how in

56 ption and a high metabolic COMT capacity for methylation are key factors for high HVAL concentrations

57 DNA secondary structures and methylation are two well-known mechanisms that regulate

58 cting m(6)A, the researchers show that m(6)A methylations are enriched in exons and are added to tran

59 escents, we demonstrate that changes in gene methylation associated with lower socioeconomic status (

60 first to demonstrate the involvement of DNA methylation-associated alterations in patients with mono

61 Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median absolu

62 previously reported BMI-related differential methylation at 83 CpGs that replicated across cohorts; B

63 factors, reside in genomic regions devoid of methylation at any stage of seed development.

64 We interrogated DNA methylation at baseline and 3 hours in peripheral blood

65 e the relationship between variations in DNA methylation at birth and the development of allergic dis

66 1B-YWHAQ) influences BP, while BP influences methylation at cg00533891 (ZMIZ1), cg00574958 (CPT1A), a

67 opean ancestry from 4 cohorts suggested that methylation at cg08035323 (TAF1B-YWHAQ) influences BP, w

68 mors, inflammation-induced tumors gained DNA methylation at CpG islands, some of which are associated

69 Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by MET

70 DNA methylation at gene promoters in a CG context is associa

71 Finally, we found that methylation at multiple CpG sites in the HOXA4 promoter

72 ation between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA,

73 CTCF is sensitive to cytosine methylation at position 2, but insensitive at position 1

74 DNA methylation at promoters is an important determinant of

75 rant hypomethylation of distal CGIs, despite methylation at proximal promoters.

76 DNA methylation at SLC7A11 was associated with reduced risk

77 our results demonstrated the association of methylation at specific genomic locations as contributin

78 by recruitment of WDR5 and concomitant H3K4 methylation at targeted genes.

79 as9-SunTag-DNMT3A dramatically increases CpG methylation at the HOXA5 locus in human embryonic kidney

80 mma gene expression through histone H4R3me2a methylation at the PPARgamma promoter.

81 We consider methylation-based tumour classification highly relevant

82 Whereas the use of Infinium Human Methylation BeadChips has shown great utility in clinica

83 epigenome-wide scan suggested differences in methylation between soy formula-fed and cow formula-fed

84 ified as most central disease-associated DNA methylation biomarkers.

85 igated and compared the effects of DOM on Hg methylation by an iron-reducing bacterium Geobacter sulf

86 DNA methylation changes associated with maternal smoking dur

87 Mutation of PKL results in DNA methylation changes at more than half of the loci that a

88 DNA methylation changes can produce meiotically stable epial

89 d that cancer-specific expression-associated methylation changes differ from tissue-specific changes.

90 es from CKD patients and show concordant DNA methylation changes in kidney cortex.

91 enes also have significant asthma-associated methylation changes in nasal epithelia of adult white as

92 3 The novel AKT3 transcriptional variant and methylation changes were confirmed using qRT-PCR and qMS

93 eading to deposition of histone H3 lysine 27 methylation chromosome-wide.

94 or isolates exhibit higher resistance to DNA methylation compared with other fungi.

95 oA synthetase Faa1, independently of the RNA methylation complex (MIS complex).

96 file of skeletal muscle, indicating that DNA methylation constitutes a rapidly adaptive epigenetic ma

97 in the subset of participants with DLPFC DNA methylation data (n = 648), we found that residual cogni

98 al lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposur

99 We evaluate DeepCpG on single-cell methylation data from five cell types generated using al

100 Next-generation RNA sequencing and DNA methylation data were generated using frozen tissue from

101 We report the first whole-genome DNA methylation datasets from single pig blastocysts showing

102 sion of hundreds of loci, acting in both DNA methylation-dependent and methylation-independent pathwa

103 e recent developments of electrochemical DNA methylation detection approaches.

104 tend to share demethylated promoters, while methylation differences between alpha- and beta-cells ar

105 s, we also found significant genome wide DNA methylation differences.

106 nalysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human interactome.

107 DNA methylation (DNAm) can be used as a biomarker of cell ty

108 Here we use the genotype and DNA methylation (DNAm) data from cord blood and peripheral b

109 es on translation could be attributed to the methylation-elicited alterations in base pairing propert

110 tenance methylated MB corresponds to de novo methylation event.

111 e combined with inhibitors targeting histone methylation for synergistic effects while still maintain

112 etter understanding of how resistance to DNA methylation from the A2UCOE is conferred, and whether th

113 D2/PHIP, which colocalizes with histone H3K4 methylation genome-wide in human cells, mouse embryonic

114 model to measure the relationship among DNA methylation, genomic segment distribution, differential

115 Histone H3 lysine 36 methylation (H3K36me) is critical for epigenetic regulat

116 Finally, using methylation haplotypes we demonstrated quantitative esti

117 Methylation has long been suspected to alter the physica

118 ne, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to

119 ls, we performed genome-wide analysis of DNA methylation, histone marking (acetylated lysine 9 in his

120 Methylation imprints are mostly lost, however.

121 d miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, followed by targeted se

122 PUFA diets increased the mean degree of DNA methylation in adipose tissue, particularly in promoter

123 ociations of prenatal lead exposure with DNA methylation in cord blood at epigenome-wide significance

124 acterized by frequent acquisition of new DNA methylation in CpG islands.

125 to define the contribution of As3MT-mediated methylation in different cell types to the development o

126 Set1A SET domain does not diminish bulk H3K4 methylation in ESCs; instead, only a subset of genomic l

127 oups that overlap with areas of differential methylation in F4 adipose tissue.

128 nonrandom XCI to examine allele-specific DNA methylation in frontal cortex.

129 p3k, indicating extensive involvement of DNA methylation in honeybee olfactory learning and memory pr

130 rove our understanding of the role of global methylation in human diseases, especially cancer.

131 SMAD3 methylation in IIS (n = 60) and in 2 replication cohorts

132 erative disorders in humans, the role of DNA methylation in mast cell biology is not understood.

133 um MethylationEPIC BeadChip for studying DNA methylation in mouse.

134 investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide DNA

135 emphasize the significance of histone lysine methylation in normal human development and the importan

136 etic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function met

137 ing about 85% of the total cellular arginine methylation in proteins.

138 We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males

139 (Hg) redox reactions and anaerobic microbial methylation in the environment.

140 Insulin increased DNA methylation in the gene body of DAPK3, a gene involved i

141 The changes in DNA methylation in the pkl mutant are correlated with change

142 disruption of bimodal, CpG density-dependent methylation in the placental progenitor.

143 suggest a potential role for impaired H3K36 methylation in their development.

144 is, with a corresponding increase in histone methylation in these tissues.

145 aternal lead exposure and epigenome-wide DNA methylation in umbilical cord blood nucleated cells in P

146 sted for association between genome-wide DNA methylation in WBCs and total IgE levels in 2 studies of

147 nt of one epigenetic mark in particular, DNA methylation, in human populations, and the examination o

148 Its expression is also regulated by DNA methylation, including at an upstream enhancer that is p

149 into two groups, on the basis of whether DNA methylation increased or decreased from active disease t

150 acting in both DNA methylation-dependent and methylation-independent pathways.

151 Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the

152 Roots treated with a DNA methylation inhibitor also showed a significant decrease

153 DNA methylation is a key epigenetic modification involved in

154 DNA methylation is a stable epigenetic mark that distinguish

155 DNA methylation is an important epigenetic mechanism that re

156 Protein methylation is an important modulator of signal transduc

157 DNA methylation is an important tissue-specific epigenetic e

158 uman populations, and the examination of DNA methylation is becoming increasingly common in psycholog

159 ogical validation showed that PCSK9 promoter methylation is conserved across tissues and positively c

160 Potent methylation is dependent on the multimerization of Dnmt3

161 In both plants and animals, DNA methylation is involved in the regulation of gene expres

162 on factors within regulatory CGIs, where DNA methylation is rare.

163 na's 450k array and showed that aberrant DNA methylation is significantly altered at enhancer regions

164 ic silencing of RAD51C and BRCA1 by promoter methylation is strongly associated with signature 3 and,

165 e of miR487b editing, as well as 2'-O-ribose-methylation, is increased in murine muscle tissue during

166 yrosine kinase domain of EGFR, and that this methylation leads to enhanced activation of its downstre

167 Global DNA methylation level (%5-mC) was quantified using ELISA met

168 tive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Esch

169 tly altered at enhancer regions and that the methylation levels at specific enhancers predict overall

170 Certain gene bodies with the highest methylation levels correlate with lower expression level

171 The genome-wide investigation of DNA methylation levels has been limited to reference transpo

172 Next, we quantified CDH1 promoter methylation levels in CDH1 mutation-positive families, i

173 We analyzed DNA methylation levels of inflammasome-related genes in pati

174 Moreover, as methylation levels of neighboring CpG sites are known to

175 placentas not associated with differences in methylation levels of the H19ICR.

176 Indeed, we detected stark differences in methylation levels within promoters and regulatory regio

177 tion of these DMRs revealed differential DNA methylation localized to a 600 bp region in the promoter

178 in wild cottons but highly expressed due to methylation loss in all domesticated cottons tested.

179 at ORCA coordinates with the histone and DNA methylation machinery to establish a repressive chromati

180 ChIPseq analysis for FOXF1 and histone methylation marks identified DNA regulatory regions with

181 Emerging evidence suggests presence of methylation marks on mitochondrial DNA (mtDNA); but thei

182 -familial and familial NSCLP and altered DNA methylation may be a second hit contributing to penetran

183 DNA methylation may be one of the underlying mechanisms for

184 , these data suggest that differences in DNA methylation may partly explain the enantioselectivity of

185 However, methylation may vary in specific RE and play diverse rol

186 chor to help decipher the likely role of DNA methylation measured in peripheral blood in the etiology

187 e Bisulfite Sequencing provides high-quality methylation measurements at the resolution of nucleotide

188 Collectively, our data revealed a novel rRNA methylation mechanism by a radical SAM superfamily enzym

189 Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) pr

190 l blood to identify SNPs associated with DNA methylation (meQTL lists).

191 leotide polymorphisms (SNPs) and genome-wide methylation (methylation quantitative trait loci [mQTLs]

192 rehensive molecular profiling, including DNA methylation microarray analysis, and did unsupervised cl

193 ring method and an R function which uses DNA methylation microarray data to infer tumor subtypes with

194 In patients with increased DNA methylation, MPO and PRTN3 expression correlated with DN

195 f cancer samples, using gene expression, DNA methylation, noncoding microRNA, and copy number variati

196 om the 2 diet groups were combined, the mean methylation of 1444 genes, including fatty acid binding

197 PNP pincer complex was shown to catalyze the methylation of 2-naphtol rather than its aminomethylatio

198 tudies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart

199 and HBV replicating cells, and examined DNA methylation of a CpG island located downstream from SALL

200 or during recovery from LT-IH prevented DNA methylation of AOE genes, normalized the expression of A

201 on by M6CK results in a dramatic decrease in methylation of arginines adjacent to M6CK-phosphorylated

202 DNA promoter methylation of cyclin D1 regulators were assessed and co

203 A key finding was that the methylation of cytosine at the specific CpG dinucleotide

204 Chromatin modifications, such as cytosine methylation of DNA, play a significant role in mediating

205 biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics.

206 DNA methylation of HDAC4 CpG sites were tagged by a nearby s

207 ngs report that DNMT3B shapes intragenic CpG-methylation of highly-transcribed genes.

208 tution and NSD1 defects converge on altering methylation of histone H3 at K36 (H3K36), subsequently b

209 PRMT5 methylation of histone H3R2me1 induced transcriptional a

210 ically, COX2/PGE2 signaling induced promoter methylation of let-7, resulting in its downregulation an

211 and PG species was developed after one-step methylation of lipid extracts in combination with high m

212 ient to increase ANO1 expression, suggesting methylation of positively correlated CpG's likely serves

213 Only a few studies have investigated DNA methylation of selected candidate genes or a very small

214 levels in OA chondrocytes and the percentage methylation of the CpG sites in the RUNX2 P1 promoter.

215 he production of 2-hydroxyglutarate, reduced methylation of the Foxp3 gene locus, and increased Foxp3

216 ne extraction and assembly, is followed by N-methylation of the mature (pseudo)pilin N terminus.

217 Many viral RNAs are modified by methylation of the N(6) position of adenosine (m(6)A).

218 Methylation of the same CpG was positively associated wi

219 ed by real-time quantitative RT-PCR, and DNA methylation of their promoter regions was analyzed by PC

220 In addition, promoter methylation of two translationally relevant genes, Schla

221 al cognition was related to differential DNA methylation of UNC5C and ENC1 (false discovery rate < 0.

222 the transcriptional levels, but not the DNA methylation, of the Peg3 domain.

223 igated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial samp

224 Arginine methylation on histones is a central player in epigeneti

225 actor receptor (EGFR), the effect of protein methylation on its function has not been well characteri

226 RS and polydextrose did not affect SFRP1 methylation or alter the expression of 10 microRNAs pred

227 s result suggests that quantitatively little methylation or demethylation occurs in cytoplasmic mRNA.

228 ric point of effector proteins, induce their methylation or demethylation, and alter their conformati

229 This effect may occur in vivo for DNA methylation outside CpG islands (CGIs) and could facilit

230 Abnormal methylation pattern could contribute to the pathogenesis

231 Although altered DNA methylation patterns and mutations in DNMT3A correlate w

232 BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intes

233 covered characteristic accessibility and DNA methylation patterns at DNase hypersensitive sites (DHSs

234 Here, we compare genome-wide methylation patterns between isogenic ESC and EGC lines

235 pluripotent stem cells (iPSCs) show variable methylation patterns between lines, some of which reflec

236 reliable detection of disease-associated DNA methylation patterns has major potential to advance mole

237 rthermore, we identified distinct epigenetic methylation patterns that are conserved across tissues,

238 le (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future therapeut

239 - treated FAP patient tissue after which the methylation patterns were visualized by Next Generation

240 Epigenetic modifications, including DNA methylation, play an important role in the pathogenesis

241 randomization approach to assess whether DNA methylation plays a mediating and causal role in associa

242 Comprehensive studies have shown that DNA methylation plays vital roles in both loss of pluripoten

243 e effect of genome sequence variation on DNA methylation precludes a comprehensive assessment of the

244 le in accuracy to other state-of-the-art DNA methylation prediction algorithms.

245 n and glucose exposure acutely alter the DNA methylation profile of skeletal muscle, indicating that

246 equently performed the best, followed by DNA methylation profile.

247 Genome-wide methylation profiles for different clones within almond

248 ongitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of P

249 The advent of high-throughput DNA methylation profiling techniques has enabled the possibi

250 mory cells was coupled to erasure of de novo methylation programs and re-expression of naive-associat

251 Moreover, these exhaustion-associated DNA-methylation programs were acquired in tumor-infiltrating

252 n is coupled to preservation of acquired DNA methylation programs.

253 orphisms (SNPs) and genome-wide methylation (methylation quantitative trait loci [mQTLs]) were identi

254 We found significant cis-methylation quantitative trait loci at 64% of the 193 Cp

255 ith levels of inflammatory markers using cis-methylation quantitative trait loci single nucleotide po

256 e loci that are targeted by RNA-directed DNA methylation (RdDM).

257 (MTHFR) generates methyltetrahydrofolate for methylation reactions.

258 However, the extent of DNA methylation reprogramming in plants remains unclear.

259 ecreased 2HG, maintenance of G-CIMP, and DNA methylation reprogramming outside CGI.

260 osarcoma cells was downregulated by promoter methylation, resulting at least in part from increased e

261 To examine whether this aberrant methylation results from genetic variation or non-geneti

262 tin, these losses are counteracted such that methylation returns to a normal level over four generati

263 rovide additional mechanisms by which lysine methylation signaling impacts on cell fate decisions.

264 of A/B compartments precedes and defines DNA methylation signatures during differentiation and matura

265 Methylation signatures identified a layer 6 excitatory n

266 nning method that incorporates bacterial DNA methylation signatures, which are detected using single-

267 f the fusion proteins selectively alters the methylation state and also regulates gene activity.

268 of the EBV type III latency program and DNA methylation state.IMPORTANCE Epstein-Barr virus (EBV) la

269 overage and hence methods to predict missing methylation states are critical to enable genome-wide an

270 I IFN-alpha/beta protein levels with the DNA methylation status as well as the expression profiles of

271 lopment of allergic disease, we examined the methylation status of CpG loci within the promoter regio

272 Thus, changes in the DNA methylation status of the PRTN3 promoter may predict the

273 Gene expression levels were opposite to methylation status, and both correlated with birth weigh

274 IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation with final cha

275 of Tv6-931 can perform two consecutive alpha-methylation steps on the last beta-keto intermediate to

276 ncing (WGBS) data that enable us to quantify methylation stochasticity genome-wide using Shannon's en

277 the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to re

278 iver to have a pattern of acquisition of DNA methylation targeted to candidate enhancers active in li

279 CG methylome and entirely miss two forms of methylation that are common in brain and likely of parti

280 gests the existence of context-specific H3K4 methylation that regulates transcriptional outputs durin

281 are needed to determine MGMT activity as DNA methylation, the current standard, does not accurately r

282 The ratio of methylation to demethylation varied between 0.3 and 1.5,

283 e during cellular reprogramming requires DNA methylation to silence somatic gene expression and dynam

284 We precisely map RNA-programmed DNA methylation to targeted CpG sites as a function of dista

285 wild type RUNX2 promoter was decreased upon methylation treatment in vitro.

286 Inhibition of DNA methylation triggers changes in the histone modification

287 amework that learns a regulatory code of DNA methylation using a deep convolutional neural network an

288 ear to what extent robust stress-induced DNA methylation variation can underpin stress memory.

289 he exploratory study of the major sources of methylation variation, which should lead to a deeper und

290 ted across cohorts; BMI-related differential methylation was associated with concurrent changes in th

291 Dynamic local methylation was evident during gastrulation, which enabl

292 Differential DNA methylation was found in only a small subset of symbioti

293 Foxp3 methylation was increased in peanut extract-sensitized a

294 scriptase-polymerase chain reaction, and DNA methylation was quantified at 7 CpG sites within the SFR

295 of the NCR genes, whereas in most genes DNA methylation was unaffected by the ploidy levels and was

296 DIP2B, which is involved in DNA methylation, was localized with 5-methylcytosine in the

297 Cytokines and transcription factor gene methylation were assessed.

298 ation is suggested, as no differences in DNA methylation were observed between 24-h aerobically and a

299 eotide and a small-molecule inhibitor of DNA methylation, which, together, achieve 30,000-fold MECP2

300 We then investigated the association of DNA methylation with levels of inflammatory markers using ci