ライフサイエンスコーパス: methylation status

1 ion included clinical factors and tumor MGMT methylation status.

2 GATA1, and USF1) factors was not affected by methylation status.

3 Efficacy did not differ by methylation status.

4 l donor betaine to modulate inflammatory and methylation status.

5 omide for newly diagnosed GBM, regardless of methylation status.

6 utarate (2HG) can cause changes in chromatin methylation status.

7 nhancer activities in response to changes in methylation status.

8 ethylation, histone acetylation, and histone methylation status.

9 H19) and potentially other genes of unknown methylation status.

10 ghtly coordinated and coupled to target site methylation status.

11 he two sense pancRNAs did not change the DNA methylation status.

12 activity, independent of the MMP13 promoter methylation status.

13 . coli, irrespective of its dam, dcm, or hsd methylation status.

14 ent gene transcripts without affecting FoxP3 methylation status.

15 on of these genes through changes in histone methylation status.

16 ld be related to the modification of the DNA methylation status.

17 uanine-DNA methyltransferase (MGMT) promoter methylation status.

18 ing its expression by regulating its histone methylation status.

19 e to recombine correlated inversely with its methylation status.

20 non-normalised hybridisation data to define methylation status.

21 y in other assay formats used to analyze CpG methylation status.

22 s located in 6q12-27 for characterization of methylation status.

23 d by protein isoforms, transcribed mRNA, and methylation status.

24 ffect of PTSD on cortical thickness via SKA2 methylation status.

25 tematic re-evaluation of the mosquito genome methylation status.

26 aintenance of lineage-specific chromatin and methylation status.

27 ntified, and O-GlcNAc levels regulated their methylation status.

28 e-DNA-methyltransferase gene (MGMT) promoter methylation status.

29 the silenced gene with no change in promoter methylation status.

30 lls, also identifying in the RORC2 and IL17A methylation status a novel tool for their distinction fr

31 oligodendroglial elements, and MGMT promoter methylation status, analysed by intention to treat.

32 s were used to identify associations between methylation status and 21 dietary variables hypothesized

33 The DNA methylation status and a repressive histone modification

34 our claim that a methyl-rich diet can affect methylation status and consequent transcriptional regula

35 t epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-gen

36 interactions at enhancers, we find that DNA methylation status and enhancer activity during early ze

37 y showing an inverse correlation between DNA methylation status and expression level.

38 ant association was observed between RASSF1A methylation status and HNSCC risk under a random-effects

39 ism may play an essential role in regulating methylation status and liver injury in Wilson's disease

40 These results also suggest that promoter methylation status and miRNA expression levels represent

41 f the ferT RNA was also regulated by the DNA methylation status and paralleled the expression profile

42 Among the genes whose DNA methylation status and RNA expression were both signific

43 Genome-wide differences in DNA methylation status and RNA expression were demonstrated

44 copy number variations, chromatin structure, methylation status and transcription factor binding.

45 Gene expression levels were opposite to methylation status, and both correlated with birth weigh

46 F (V600E) mutation status, mut-L homologue 1 methylation status, and disease-specific survival in the

47 I "PGFRA," RTK II "classic"), MGMT promoter methylation status, and hallmark copy number variations

48 r markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/IDH2 mutations).

49 a late step of reprogramming associated with methylation status, and implicated a secondary set of pl

50 levels, anti-ADI-PEG20 antibody titer, ASS1 methylation status, and metabolic response by 18F-fluoro

51 lical structure facilitates sampling of H3K4 methylation status, and proffers H3K9 and other residues

52 regardless of its sequence, CpG content, or methylation status, and required signaling through the a

53 IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation with final cha

54 Based on the potential use of global DNA methylation status as a biomarker of disease status and

55 eded to investigate the potential of DNA-(de)methylation status as a predictor for BF as well as for

56 To enable monitoring of methylation status as it changes over time, we establish

57 I IFN-alpha/beta protein levels with the DNA methylation status as well as the expression profiles of

58 Our data comprises the methylation status at 12 CpGs near the 5' end of the CpG

59 e methylation and demethylation and that the methylation status at a single lysine residue confers di

60 However, it is presently unclear how methylation status at individual genes is targeted for m

61 at inflammatory cytokines can change the DNA methylation status at key CpG sites, resulting in long-t

62 otency-associated transcription factors, DNA methylation status at pluripotent cell-specific genes, a

63 abled quantitative measurement of single CpG methylation status at relatively low cost and sample inp

64 tion imparts differential maintenance of DNA methylation status at Tet1 targets, ultimately contribut

65 A gradual change in methylation status at the boundaries of hypomethylated r

66 sequencing has been used to characterize DNA methylation status at the genome scale, but suffers from

67 ylation and changes in the H3K27 acetylation/methylation status at the Il13 locus.

68 dependently established the correct cytosine methylation status at the target CG of each molecule tes

69 d that there was a strong correlation on the methylation status between different generations in the

70 nia, together with the stable inheritance of methylation status between generations, suggests either

71 transcript levels (by quantitative PCR), DNA methylation status (by bisulfite pyrosequencing), and GA

72 a classification-based procedure, called the methylation status calling (MSC) procedure, to make bina

73 mate that Q40 values (0.01% error rates) for methylation status calls could be achieved by reading si

74 atus calling (MSC) procedure, to make binary methylation status calls.

75 sfactory in applications that require binary methylation status calls.

76 No DNA methylation status changes were detected upon Ureaplasma

77 ed or had no significant change in their DNA methylation status compared with normal pregnancy.

78 nks between developmental changes in histone methylation status, congenital disorders and MR.

79 methylguanine-DNA methyltransferase promoter methylation status, contrast enhancement, initial treatm

80 Alterations in MVP methylation status create epigenetic patterns that appea

81 Finally, gene methylation status determines the expression of several

82 grate their genome into the host genome, the methylation status during this stage has been studied ex

83 as validated by quantification of global DNA methylation status following treatment of cells with the

84 have been developed to interrogate cytosine methylation status genome-wide, however these assays mus

85 Changes in histone lysine methylation status have been observed during cancer form

86 equencing is widely used for analysis of DNA methylation status (i.e., 5-methylcytosine [5mC] vs. cyt

87 DNA (gDNA) to analytically infer polymorphic methylation status (i.e., 5-methylcytosine [5mC] vs. cyt

88 gulatory T cell-specific demethylated region methylation status in 1-month biopsy samples revealed a

89 By measuring reelin expression and promoter methylation status in 39 primary breast tumors, as well

90 ations establish a link between SAMe and DNA methylation status in a defined biological system, provi

91 chronological profile of the genome-wide DNA methylation status in a human myoblast differentiation m

92 We determined the methylation status in a panel of 14 markers (7 canonical

93 n levels were negatively associated with the methylation status in beef cattle (P < 0.05).

94 thylViewer can simultaneously query cytosine methylation status in bisulfite-converted sequences at a

95 enous Bt toxins, Bt-transgene expression and methylation status in Bt rice exposed to two levels of C

96 The specific importance of the DNA methylation status in CD4(+) T cells could be confirmed

97 were then selected for analysis of promoter methylation status in cell lines and primary RCC.

98 itors allow unprecedented control of the DNA methylation status in cells and will lead to further adv

99 ixed cell population, the change in promoter methylation status in chronic periodontal disease sugges

100 dy, we investigated gene copy number and CpG methylation status in CRPC to gain insight into specific

101 eatment followed by pyrosequencing confirmed methylation status in juvenile DM and other IIMs.

102 Promoter methylation status in long interspersed nucleotide eleme

103 CpG methylation status in normal cells points to locally act

104 rmed DNA bisulfite sequencing to compare the methylation status in postmortem retina pigment epitheli

105 inting but is a strong factor in determining methylation status in preimplantation embryos, suggestin

106 stered these profiles according to their DNA methylation status in primary normal and tumor tissues.

107 ntial of these sensors in monitoring histone methylation status in response to histone methyltransfer

108 DNA methylation patterns independent of its methylation status in sperm.

109 DNA methylation status in the AMP promoter regions was also

110 on level of cBDNF1 may be related to the DNA methylation status in the chickens.

111 This heterogeneous CpG island DNA methylation status in the tumors is unusual in that othe

112 can be manipulated by altering its cytosine methylation status in vitro.

113 t ORTH proteins are E3 ligases mediating DNA methylation status in vivo.

114 ations and epimutations (changes in cytosine methylation status) in mutation accumulation (MA) lineag

115 ioids, can influence neuronal-cell redox and methylation status including DNA methylation.

116 long-term influence of morphine on redox and methylation status (including DNA methylation levels) in

117 Altered DNA methylation status is associated with human diseases and

118 ation at both K4 and K79, indicating that H3 methylation status is not solely dependent on H2B ubiqui

119 The methylation status is stably maintained even after CpG-f

120 re is a clear rational for the definition of methylation status, it uses DMH data without between-gro

121 )-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of tr

122 of active DNA demethylation, how genome DNA methylation status might be sensed to regulate the expre

123 , thus making it an ideal system to evaluate methylation status more closely.

124 drocytes, consistent with the differences in methylation status observed in vivo in normal and human

125 The methylation status of > 485,000 CpG loci was interrogate

126 In the present work, the methylation status of >145,000 CpGs from 5,472 promoters

127 We have used this method to determine the methylation status of >275 million CpG sites in human an

128 The methylation status of 1,421 autosomal CpG sites located

129 We evaluated the methylation status of 11 genes (MINT1, 2, 31, hMLH1, p16

130 The methylation status of 13 candidate genes (CDO1, CNRIP1,

131 Methylation status of 17 CpG sites in PLAC8 negatively c

132 The methylation status of 2 of these candidate genes, BCL-2

133 We have examined the methylation status of 27 578 CpG dinucleotides in 72 CdL

134 Activation changed the methylation status of 466 CpGs and 18 RDMs in Naive but

135 Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate gen

136 The method was scaled to interrogate the methylation status of 77,674 CpGs in the promoter region

137 We therefore investigated the methylation status of a 1512 bp typical CpG island locat

138 4 levels was observed to be dependent on the methylation status of a miR-494 promoter-associated CpG

139 Recent studies suggest that the methylation status of a number of genes is dynamically r

140 get poorly transcribed loci by "reading" the methylation status of a particular lysine residue of his

141 In contrast, measurement of the DNA methylation status of a region within the FOXP3 locus th

142 However, monitoring the methylation status of a specific cytosine biomarker is o

143 This enabled the methylation status of a specific cytosine to be accurate

144 lity in liver tissue, based on comparing the methylation status of adjacent CpG sites on long sequenc

145 ite-converted whole genomes to determine DNA methylation status of an entire genome, which has hereto

146 bisulfite sequencing studies to address the methylation status of Arabidopsis thaliana telomeres.

147 expression of regulatory markers, and FOXP3 methylation status of blood TFR is comparable with tonsi

148 ction in CaM KMT revealed a link between the methylation status of CaM and root length.

149 We sought to elucidate whether the methylation status of CaM plays a role in CaM-mediated s

150 nstitutive and T-cell activation-induced DNA methylation status of CCR5 cis-regulatory regions (cis-r

151 Methylation status of CCR5 intron 2 explains a larger pr

152 Methylation status of CDKN2A, PTEN, and RASSF1A gene pro

153 f single CpG sites are representative of the methylation status of corresponding regions of interest.

154 sferase in mouse and human and regulates DNA methylation status of CpG island-associated promoters in

155 lopment of allergic disease, we examined the methylation status of CpG loci within the promoter regio

156 viruses--particularly small DNA viruses--the methylation status of CpG motifs is rarely known and the

157 Notably, the methylation status of CpG residues within the CTCF targe

158 The methylation status of CpG sites close to the trinucleoti

159 Differences in methylation status of CpG sites, monoallelic silencing,

160 for the multiplexed interrogation of the DNA methylation status of cytosine-guanine dinucleotide isla

161 e high level of accuracy for identifying the methylation status of cytosines in DNA, could find broad

162 Our integrated analysis demonstrates that methylation status of different genomic regions may play

163 arate-dependent dioxygenases that modify the methylation status of DNA by successively oxidizing 5-me

164 We fit a mixed model with the methylation status of each CpG as the dependent variable

165 ic pathways, and detailed information on the methylation status of each cytosine in any given genome

166 The global CpG methylation status of eel liver was determined by means

167 The methylation status of ERalpha has implications for repro

168 the downregulation, we examined the promoter methylation status of GPC5 gene.

169 e that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promot

170 date, a small number of enzymes that control methylation status of histones have been identified as c

171 In this study, we analyzed the methylation status of human promoters in rheumatoid arth

172 The DNA methylation status of human X chromosomes from male and

173 We conclude that the DNA methylation status of IEGs plays a crucial role in FS-in

174 p between maternal PAH exposure and promoter methylation status of IFNgamma and IL4.

175 Many studies have reported the methylation status of individual genes with known involv

176 egulated expression of BRCA1 by altering the methylation status of its promoter.

177 Together, these findings show that the methylation status of m(6)Am in the 5' cap is a dynamic

178 We determined the methylation status of miR-137 CpG island in a panel of s

179 Here, we examined the methylation status of MMP13 promoter and report the deme

180 healthy control livers were analyzed for the methylation status of more than 14,000 genes.

181 Although the methylation status of most CpG dinucleotides in the geno

182 ethod can reliably and accurately detect the methylation status of multiple target sites in each sing

183 ion content and a reduced correlation in the methylation status of neighboring cytosine--phosphate--g

184 rences) but were only weakly affected by the methylation status of neighboring cytosines.

185 ociated with decreases in both the redox and methylation status of neuronal cells, as defined by the

186 Aberrations in the methylation status of noncoding genomic repeat DNA seque

187 cessfully applied this model to evaluate DNA methylation status of normal human melanocytes compared

188 identified 10-base periodicities in the DNA methylation status of nucleosome-bound DNA and found tha

189 high-resolution microarray that detects the methylation status of over 25,000 CpG islands in the hum

190 To test this, we analyzed the methylation status of over 27,000 CpGs mapping to promot

191 We have analyzed the methylation status of over 28,000 CpG islands and 18,000

192 entiation of epiblast cells to PGCs, how DNA methylation status of PGCLCs resembles the dynamics of 5

193 To understand the mechanism DNA methylation status of POLG1 promoter was investigated by

194 Recent reports indicate that the methylation status of promoter proximal CpG dinucleotide

195 as single-CpG resolution and can address the methylation status of repeated sequences.

196 ethod, we characterized the landscape of the methylation status of repetitive elements, such as LINEs

197 sponse and characterization of molecular and methylation status of responders were secondary objectiv

198 Interestingly, the DNA methylation status of resting cells was highly predictiv

199 function had a clear impact not only on the methylation status of RhoA but also RhoA activation and

200 ates with male infertility, we evaluated the methylation status of RHOX genes in sperm from a large c

201 Here we show that the methylation status of rRNA differentially influenced the

202 iR-200b) and pyrosequencing to determine CpG methylation status of selected genes (Aph1a and Dkk4) in

203 Associated with this was an increased methylation status of several CpG dinucleotides in the p

204 We have also examined the methylation status of several CpG islands in this region

205 The methylation status of several nearby zinc finger genes w

206 This suggests that the DNA promoter methylation status of some steroid responsive genes in t

207 RUNX2 gene transcription is regulated by the methylation status of specific CpG sites in the promoter

208 tudy aimed to determine the influence of the methylation status of specific CpG sites in the RUNX2 pr

209 drocytes is controlled by changes in the DNA methylation status of specific CpG sites of the proximal

210 U.S. population, to have effects on the DNA methylation status of specific genes in the placenta and

211 memory and imprinting by regulating the CpG methylation status of specific promoter regions.

212 argets by two rounds of PCR to determine the methylation status of target sites.

213 analyzed complementary DNA and evaluated the methylation status of the androgen receptor gene.

214 resistance was associated with an increased methylation status of the catalytic subunit of protein p

215 the insertion affects the maintenance of the methylation status of the CpG island of the modified bet

216 performed the first systematic survey of DNA methylation status of the CpG islands of the PEG3 (Pater

217 These observations indicate that the methylation status of the CYP24 promoter differs in endo

218 racterizing the functional links between the methylation status of the DNA and of two particularly im

219 We subsequently studied the DNA methylation status of the Eph/ephrin family by bisulfite

220 associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43

221 ry sclerosing cholangitis controls), and the methylation status of the four best performing markers w

222 re in all AML blasts irrespective of the DNA methylation status of the gene.

223 ha (3-fold; P = 0.035) without affecting the methylation status of the gene.

224 Through its SET domain, WHSC1 regulates the methylation status of the histone H4 K20 residue and is

225 n, we determined the effects of GRHL2 on the methylation status of the hTERT promoter.

226 Assessment of the DNA methylation status of the identified genes could contrib

227 (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in

228 In addition, we evaluated methylation status of the IFNgamma promoter in cord whit

229 Anti-IL-1beta did not alter the methylation status of the IL-1beta promoter.

230 e aims of this study were to compare the DNA methylation status of the IL6 promoter in rheumatoid art

231 oss of methylation at a CpG depends upon the methylation status of the immediately preceding CpG.

232 The DNA methylation status of the iNOS promoter and enhancer reg

233 also observed significant differences in the methylation status of the insertion sites among MITE fam

234 These data also show that the DNA methylation status of the intronic CpG island affects tr

235 i and performed manually-curated matching of methylation status of the key regulatory sequences (prom

236 f normal and tumor tissues revealed that the methylation status of the majority of CpG sites adjacent

237 Retrospectively, the methylation status of the methyl-guanine methyl transfer

238 f MITF did not alter the expression level or methylation status of the MITF pathway genes.

239 Therefore, we determined the methylation status of the MSH2 gene in 268 CRC tissues,

240 y, however, the results indicated that the O methylation status of the OPS antigens was also affected

241 We aimed to investigate whether the methylation status of the P2Y12 promoter has effects on

242 was not accompanied with changes in the DNA methylation status of the Peg3 domain.

243 ethylesterase-1 (PME-1), thus preserving the methylation status of the PP2A catalytic subunit.

244 The methylation status of the promoter of O(6)-methylguanine

245 , phosphatase and tensin homolog (PTEN), and methylation status of the promotor region of the MGMT ge

246 Thus, changes in the DNA methylation status of the PRTN3 promoter may predict the

247 he brain of Xenopus embryos, we analyzed the methylation status of the RASSF10-associated 5'-CpG isla

248 f these CpG sites, we also evaluated the DNA methylation status of the rDNA promoter in prostate canc

249 etylation and methylation as well as the DNA methylation status of the TEs.

250 that involves random transitions in the DNA methylation status of the VWF promoter.

251 hout their juvenile phase can affect the DNA methylation status of their oocytes during gonad maturat

252 We assessed the methylation status of these genes and of the repetitive

253 We also show that the methylation status of these genes can cluster important

254 We examined the methylation status of these genes in a test set consisti

255 cAMP response elements, suggesting that the methylation status of these loci could serve as a mechan

256 The methylation status of these regions was obtained from th

257 The methylation status of these sites had a significant impa

258 ated CpG island, binds GLI2 depending on the methylation status of this CpG island, and physically in

259 rategy for parallel determination of the CpG-methylation status of thousands of Alu repeats, and a co

260 this method, we present data on the regional methylation status of two CpG clusters located in the EN

261 can improve over existing DMR detection (i) methylation statuses of nearby CpG sites are highly corr

262 9-2 with microsatellite instability and MLH1 methylation status (P < 0.001) and poor overall survival

263 Consistent with this, H4K20 methylation status plays a direct role in recruiting ORC

264 icrosatellite instability status, CpG island methylation status, PTEN loss, EGFR expression, and copy

265 Analysis of the tumor suppressor gene p16 methylation status revealed a clear reduction in methyla

266 P53INP1, and DDAH1 genes at the level of DNA methylation status, RNA, and protein-level expression.

267 rd, TE insertions are distributed by age and methylation status, such that older, methylated TEs are

268 ncer iHMRs are more variable in sequence and methylation status than any other functional class, cons

269 We identified 195 genes with changes in methylation status that were significantly associated wi

270 Klf10 expression was primarily regulated by methylation status, the Klf10 promoter was examined by m

271 promoters, are the most dynamic in their DNA methylation status throughout development and differenti

272 n >/=5% and a 5-95% range >/=10%, we related methylation status to maternal pregnancy diet and to chi

273 r the quantitative measurement of global DNA methylation status using ultra-performance liquid chroma

274 d to capture PCR amplicons and determine the methylation status via fluorescence resonance energy tra

275 In multivariate analysis, melanoma AIM1 methylation status was a significant prognostic factor o

276 DNA methylation status was altered in IPF.

277 LINE-1 and AIM1 methylation status was assessed in paraffin-embedded arc

278 11p15 methylation status was associated relapse (20% relapse w

279 Methylation status was categorized as low (fewer than tw

280 nts indicated that histone 3 lysine 9 (H3K9) methylation status was changed in elf6 and ref6 mutants,

281 The methylation status was confirmed by pyrosequencing.

282 as not affected, but global protein arginine methylation status was decreased (10-35%) in liver and b

283 Methylation status was determined using bisulfite genomi

284 Methylation status was evaluated for CACNAG1, SOCS1, RUN

285 COX-2 methylation status was initially assessed by capillary a

286 In addition, global DNA methylation status was not affected, but global protein

287 The pooled results showed that MGMT promoter methylation status was significantly associated with an

288 st this hypothesis, DNA and protein arginine methylation status were assessed in liver, brain, heart,

289 Global DNA and protein arginine methylation status were evaluated as the contents of 5-m

290 Thus, the activity of Dam MTase and methylation status were sensitively converted to the DNA

291 features and outcomes based on PTEN promoter methylation status were then analyzed using SPSS and R.

292 c end points of correlative studies of COX-2 methylation status were time to recurrence, overall surv

293 on levels correlated inversely with promoter methylation status, whereas demethylation increased reel

294 etylation and, to a secondary degree, by its methylation status, which aided in the interpretation of

295 pG sites (CpG11 and CpG12 + 13) showed lower methylation status, which correlated with a strong assoc

296 pancreatic cancer is correlated with altered methylation status, which seems to be regulated by DNMT1

297 ybrid offspring, recapitulating the parental methylation status with nearly 100% fidelity, indicating

298 We related these to offspring methylation status within 3 maternally methylated imprin

299 Examination of genome-wide DNA methylation status within 928 TE subfamilies in human em

300 P exposure, adverse health outcomes, and DNA methylation status within human populations.