ライフサイエンスコーパス: methylenecyclopropane

1 CO(2)D gives ring-opened products as well as methylenecyclopropane.

2 ly weak allylic C-H bonds (99.3 kcal/mol) of methylenecyclopropane.

3 for the sigmatropic rearrangement of alkenyl-methylenecyclopropanes.

4 unimolecular rearrangement of 2,2-dichloro-1-methylenecyclopropane (1) to (dichloromethylene)cyclopro

5 a)-C(beta) ring cleavage reaction, 1-amino-2-methylenecyclopropane-1-carboxylic acid (2-methylene-ACC

6 1-Amino-2-methylenecyclopropane-1-carboxylic acid (2-methylene-ACC

7 The 2,2-bis(hydroxymethyl)methylenecyclopropane (11) was converted to dibromo deri

8 atalyzed reaction of ethyl diazoacetate with methylenecyclopropane 19, obtained from 2-bromo-2-bromom

9 y Se oxidation and beta-elimination gave cis-methylenecyclopropane 22.

10 lation (30), and oxidation-elimination trans-methylenecyclopropane 31.

11 The greater SE of methylenecyclopropane (39.5 kcal/ mol), relative to meth

12 tes 11a, 11b, 12a, and 12b afforded E- and Z-methylenecyclopropanes 4a, 4b, 5a, and 5b.

13 ormation of a base-stabilized B,N-containing methylenecyclopropane 7.

14 dipolar cycloadditions, a thermally promoted methylenecyclopropane acetal cycloaddition, and a Pd-cat

15 nd 31 + 32 with DIBALH afforded (Z)- and (E)-methylenecyclopropane alcohols 14 + 16 and 33 + 34.

16 a and 11b derived from 2,2-bis(hydroxymethyl)methylenecyclopropane analogues 1a, 1b, 2a, and 2b were

17 - and E-stereoisomers of (1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and

18 The second generation of methylenecyclopropane analogues of nucleosides 5a-5i and

19 important for synthesis of antiviral purine methylenecyclopropane analogues of nucleosides, is also

20 A series of 13 new (S,Z)-2-aminopurine methylenecyclopropane analogues was synthesized, and the

21 hips will be discussed in context with other methylenecyclopropane analogues.

22 Methylenecyclopropanes are important synthetic intermedi

23 tablished for 26,27-DHZ, suggesting that the methylenecyclopropane can serve as a lead structure for

24 The purine (Z,E)-methylenecyclopropane carboxylates 13 and 24 were select

25 Certain 1,1-dimethyl-2-aryl-3-methylenecyclopropanes containing carbonyl substituents

26 enhancements in a series of aryl-substituted methylenecyclopropanes correlate with sigma(+) values.

27 rine (30) with 24 + 25 afforded (Z)- and (E)-methylenecyclopropane derivatives 26 + 27 and 31 + 32.

28 cular Diels-Alder furan cycloaddition, and a methylenecyclopropane dienophile was used for a stereose

29 Several Z-(hydroxymethyl)methylenecyclopropanes exhibited in vitro antiviral acti

30 Nitrogen-substituted methylenecyclopropanes have been prepared by a strain-dr

31 n intramolecular strain-promoted Diels-Alder methylenecyclopropane (IMDAMC) reaction provided a pivot

32 of 1-methylcyclopropene relative to isomeric methylenecyclopropane is ascribed to its weak ring C-H b

33 ion of a second pair of geminal fluorines to methylenecyclopropane lowers the barrier to rearrangemen

34 a new reaction of reductive isomerization of methylenecyclopropanes (MCPs) to vinylcyclopropanes (VCP

35 ntermediate, (2) the relief of strain in the methylenecyclopropane moiety provides the thermodynamic

36 Intermolecular hydroamination of methylenecyclopropane proceeds via highly regioselective

37 thylsilylcyclopropyl alkyl ketones also gave methylenecyclopropane products derived from trimethylsil

38 The rate of the methylenecyclopropane rearrangement is enhanced by an al

39 ains open as to whether the silver-catalyzed methylenecyclopropane rearrangement proceeds via an arge

40 The three triazole groups all enhance the methylenecyclopropane rearrangement rate and are therefo

41 Silver cation also enhances the rate of the methylenecyclopropane rearrangement.

42 rect irradiation or by sensitized processes, methylenecyclopropane rearrangements do not occur.

43 The structures of the methylenecyclopropane ring-opened olefins were determine

44 New nucleoside analogues 14-17 based on a methylenecyclopropane structure were synthesized and eva

45 ddition, and a Pd-catalyzed cycloaddition of methylenecyclopropane to an oxabicyclo[3.3.0]octenone.

46 Instead, it comes from a methylenecyclopropane-type rearrangement of chemically a

47 ylthio)benzene), di- and trivinylarenes, and methylenecyclopropanes with primary amines R' 'NH(2) (R'