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3 onfirmed that UbFluor quantitatively detects naturally occurring activation states of PARKIN caused b
4 n of amide- and lactam-containing drugs, and naturally occurring alkaloids, as well as for the select
5 tification of neuroprotective genes based on naturally occurring allelic variations has the potential
7 amino ether ligands, readily accessible from naturally occurring alpha-amino- or alpha-hydroxy acids,
8 Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and
9 ndings highlight the importance of assessing naturally occurring alternative splicing for clinical ev
16 ere we show that cholesterol sulfate (CS), a naturally occurring analog of cholesterol, inhibits CD3
18 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and biomass-sourced bifunctional mon
20 IL-18 activity is modulated in vivo by its naturally occurring antagonist, IL-18 Binding Protein (I
26 ibed herein are the first total syntheses of naturally occurring antitumor agents disorazoles A1 and
29 ece of information, which is missing for all naturally occurring archaeal DNA polymerases, provides a
33 atographically and spectroscopically matched naturally occurring azaspiracid-3, whereas the previousl
34 cating that similar mutations could arise in naturally occurring bacterial populations facing antibio
36 ology of BD torons allowing consideration of naturally occurring BD texture for applications in optic
38 rface morphology of microthin fibers such as naturally occurring biofibers is essential for understan
40 , fibrin, which is one of the most resilient naturally occurring biopolymers and forms the structural
42 New nitrocatechol COMT inhibitors based on naturally occurring caffeic acid and caffeic acid phenet
43 matics and functional analyses, we show that naturally occurring cancer-associated SIRT2 mutations at
46 substrate, providing the first example of a naturally occurring catalytic antibody for polysaccharid
47 re provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthe
49 experimental vaccines have been derived from naturally occurring, cell culture-adapted, or geneticall
51 hich could be inhibited by the addition of a naturally occurring chaperone and a nanobody designed to
53 also used the predictive models to convert a naturally occurring ChR incapable of mammalian localizat
54 nins are one class of versatile and abundant naturally occurring chromophores that produce different
59 These data provide strong evidence that the naturally occurring compound, garcinol, may be a potenti
60 Through this process, we identified another naturally occurring compound, withaferin A, that also ac
62 dies, we report that methyl benzoate (MB), a naturally-occurring compound in many plants, may possess
63 mia; and summarizes LOX-1 modulation by some naturally occurring compounds and efforts toward develop
64 mplex history reflected in both selection on naturally occurring compounds and historical trade route
66 nition of triterpene glycosides, a family of naturally occurring compounds that act as chemical defen
67 en human medial temporal lobe epilepsy and a naturally occurring condition in wild sea lions and simu
69 c peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective a
70 the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety
71 Enantioselective first total synthesis of naturally occurring cytotoxic (+)-subincanadine E was al
73 -stage vaccine candidate antigen; however, a naturally occurring deletion within an immunogenic domai
74 are man-made media that mimic properties of naturally occurring dielectric media, or even manifest p
75 s include passive targeting, which relies on naturally occurring differences between healthy and dise
76 a genetic score consisting of variants with naturally occurring discordance between levels of LDL-C
77 sis of strains and phenotypic variability in naturally occurring diseases, especially in humans, more
79 ls the rate of damage per unit volume due to naturally occurring DNA breaks, whereas the volume fract
80 tein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase cau
81 are then used to generate an alignment of 73 naturally occurring DnaE inteins that are predicted to b
82 membranes is a model system for the study of naturally occurring domains, such as rafts, in biologica
83 aracterize several CGRs that originated from naturally occurring DSBs at (GAA)n microsatellites in Sa
87 e same approach, we attempted to stabilize a naturally occurring efficiently cleaved clade C Env, nam
89 g spermatogenesis, through the activity of a naturally-occurring endonuclease that targets a repetiti
90 HD is 5 kcal.mol(-1) higher than that of the naturally occurring engrailed-HD from Drosophila melanog
93 t plays a large and stabilizing role for the naturally occurring enzyme ketosteroid isomerase (KSI).
94 ut the catalytic activities or mechanisms of naturally occurring enzymes, or the evolutionary process
101 y, observations from coral communities under naturally occurring extremes have become central for imp
105 genic process and assess the interference of naturally occurring fatty acids with the transport proce
108 uarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3.
109 physiological models and robust against the naturally occurring fluctuations in the metabolic respon
110 l variants of Anabaena flavodoxin, where the naturally occurring FMN cofactor is substituted by diffe
111 Ska depletion increases the frequency of naturally occurring, force-dependent P kinetochore detac
112 ohydrate polymers is rooted in the fact that naturally occurring forms of starch, cellulose, and chit
113 cin A or methylenecyclopropylglycine (MCPG), naturally-occurring fruit-based toxins that cause hypogl
115 ic Population Resource (DSPR) as a source of naturally occurring genetic perturbation, we uncover abu
117 e of collections of wild C. elegans to study naturally occurring genetic variation, paving the way fo
118 cs of lithium extraction and production from naturally occurring geothermal and other brines for ener
121 e the high fluorescence quantum yield of the naturally occurring green fluorescence protein (GFP, Phi
122 ositions 158 to 160 of the HA protein of two naturally occurring H5N1 viruses as an important virulen
123 up M HIV-1 isolates, CRF01_AE strains have a naturally occurring histidine at this position (H375).
124 vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have
128 plete Cre-loxP recombination, thus mimicking naturally occurring human tumors resulting from one or a
130 Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, ha
131 ar mechanisms that cause drug resistance are naturally occurring in less susceptible species and are
132 el mechanobiology concept that could exploit naturally occurring in vivo forces for improving stem ce
136 nome-wide association study, we identified a naturally occurring insertion in a regulatory DNA elemen
137 the concept of intrinsic ignition, which are naturally occurring intrinsic perturbations reflecting t
138 cule representative of a large proportion of naturally occurring islet-infiltrating B-lymphocytes in
142 ge, corrects the raw MS spectra both for the naturally occurring isotopes and for the overlapping of
143 signed the Doppler-broadened features of two naturally occurring isotopes of rubidium atoms ((87)Rb a
144 uires special care, such as a correction for naturally occurring isotopes, or overlapping mass spectr
148 g in either the well-documented selection of naturally occurring, less susceptible fungal species, or
151 functions over the last five decades, these naturally occurring macrocyclic systems have emerged onl
153 ns of paleomagnetic observations assume that naturally occurring magnetic particles can retain their
160 iral Bronsted acid prepared in one step from naturally occurring (-)-menthol and readily available 1,
161 We manipulated water availability in two naturally occurring Mertensia ciliata (Boraginaceae) pop
162 showed decreased oxidation stability due to naturally occurring metals but stability increased to a
163 neity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive
164 re either epimeric at C1 and C1' or lack the naturally occurring methyl group at those positions were
165 nation are increasingly appreciated to shape naturally occurring microbe populations, the underlying
166 ular concentrations typically encountered in naturally occurring microbial communities (10(3)-10(6) c
168 One solution to this problem may lie within naturally occurring microdiversity; varying numbers of e
170 may regulate auxin levels and adds a novel, naturally occurring molecule to the chemical toolbox for
171 les such as peptides, pharmaceutical agents, naturally occurring molecules, proteins and alkaloids, a
173 e required for protective immunity against a naturally occurring murine pathogen that infects the thy
174 , stability, and lipid-binding properties of naturally occurring mutants of full-length human apoA-I
175 SR) calcium release in a mouse strain with a naturally occurring mutation in the myostatin gene (Comp
177 at often rely on laborious selection of rare naturally occurring mutations in gene-regulatory regions
180 logically significant electric fields and by naturally occurring mutations of human cyt c that, along
182 d nucleic acid binding assays to explain how naturally occurring mutations within this portion of tel
185 unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides
186 tituting Lys with Arg (or vice versa) in the naturally-occurring myosin-6 SAH similarly increased (or
187 and potentially about the physical basis of naturally occurring nanodomains such as lipid rafts.
189 Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with simil
190 Both heterocycles of carinatine A, a rare naturally occurring nitrone, were formed in a single ope
192 the development of new antibiotics, as many naturally occurring nucleoside inhibitors with antibacte
193 ne (GlcNAc) is an abundant building block in naturally occurring oligosaccharides, but its incorporat
195 tential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for i
198 s plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)-
199 elucidate the nature of sleep deficits in a naturally occurring ovine model of neuronal ceroid lipof
201 ted the effect of birnessite (delta-MnO2), a naturally occurring oxidant in soils, on the formation o
202 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain
204 e capabilities associated with a majority of naturally occurring peptaibols such as alamethicin.
208 ified an alternative binding conformation of naturally occurring peptides from Toxoplasma gondii boun
219 ucture of EBNA1 with an interface subject to naturally occurring polymorphisms that modulate EBNA1 fu
220 the ability of thymosin alpha 1 (Talpha1)-a naturally occurring polypeptide with an excellent safety
221 determining helical stability in de novo and naturally-occurring polypeptides, giving new insight int
224 Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect o
225 like oligomers in solution when triggered by naturally occurring polyphosphates (PIP2 and ATP) and ma
229 the potential for automated analysis of this naturally occurring post-translation modification in neu
230 Cysteine S-nitrosation and S-sulfination are naturally occurring post-translational modifications (PT
231 st, SR has been demonstrated in a variety of naturally occurring processes, including human perceptio
232 UMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tai
233 e by studying the geometry of beta sheets in naturally occurring protein structures and folding simul
236 pe parasites grow in any one of a variety of naturally occurring purines, the proliferation of these
238 itutions, including the highly prevalent and naturally occurring Q80K polymorphism that impacts simep
239 knot aptamers were rendered insensitive by a naturally occurring R277K variant, providing the first d
240 gy of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biolo
242 iative and dissociative processes, mimicking naturally occurring reactions and giving rise to a decou
243 seroconvert in response to diverse IAVs, and naturally occurring reassortants of CIV-H3N2 and the 200
244 f development.SIGNIFICANCE STATEMENT Probing naturally occurring reciprocal copy number variation in
247 of asthma in wild-type (WT) mice, with both naturally occurring regulatory T (nTreg) cells and induc
249 replicated with human polyclonally expanded naturally occurring regulatory T cells, which we have pr
252 ively, our data rationalize the existence of naturally occurring RG4-assembling tRNA fragments and em
253 t immunological and anatomical evidence of a naturally occurring rod-monochromatic mammalian retina,
255 ges is a platform for chemical remodeling of naturally occurring scaffolds that targets virtually all
262 igratory marine vertebrates, we measured the naturally occurring stable nitrogen isotope (delta(15) N
265 RNA-based three-way junctions (3WJs) are naturally occurring structures found in many functional
267 We therefore investigated the role of these naturally occurring substitutions in BTX autoresistance
274 MP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adju
275 perties in turn could facilitate identifying naturally occurring topologically nontrivial RNA molecul
278 onse of the aquifer system has not mobilized naturally occurring trace metals, including arsenic, chr
279 geting of histone modifications, which model naturally occurring transcriptional phenomena that contr
280 l fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and
282 the communities we detected associating with naturally occurring trees at the seedling source populat
283 vel of Foxp3 expression, or affiliation with naturally occurring Treg or induced Treg in the circulat
284 ligand-expressing MDCs, and increased donor naturally occurring Treg recovery (P < .01) compared wit
285 ausal link between aberrant FOS function and naturally occurring tumors has not yet been established.
288 d the effect of DHA on aS-derived species: a naturally occurring variant, H50Q; an oxidized aS in whi
291 rtunity to identify genes that contribute to naturally occurring variation in quantitative traits.
292 discover and validate genes contributing to naturally occurring variation in quantitative traits.
296 hydroxyvitamin D3 (1,25-D3 or calcitriol), a naturally occurring VDR agonist, VDR 4-1 therapy even at
297 itis virus (VSV), a transsynaptic tracer, or naturally occurring VSV-derived defective interfering pa
300 adaptive population, by taking advantage of naturally occurring X-linked somatic PIGA mutations in h
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