ライフサイエンスコーパス: rational

1 even for subjects whose choices appear fully rational.

2 ext-dependent even when choices appear fully rational.

3 ure of and evidence for CAMs for IBD so that rational advice can be offered to patients who inquire a

4 t leads to present bias, even for completely rational agents with time-consistent preferences.

5 is by bottom-up and top-down approaches with rational and controllable structures, to several importa

6 he catalytic properties of Rh, which enables rational and dynamic tuning of CO2-reduction selectivity

7 ive design principles exist that permit both rational and modular control of foldamer secondary struc

8 e of nanosystems, can provide criteria for a rational and molecular level-based design of AMPDs.

9 The future outlook encompasses rational and sustainable use of effective vector control

10 preferentially form the heterotrimer, and a rational annealing process led to the desired oligomer.

11 Overall, the work represents the rational application of nanotechnology for immunoenginee

12 Such systematic investigations would allow rational applications of nanomaterials', beyond cancer,

13 However, a rational approach to crystallize antibodies is still lac

14 enic profile of recently isolated bNAbs, the rational approach to immunogen design is to make a stabl

15 e and endotype patients, allowing for a more rational approach to picking a specific biologic agent f

16 elop an easy-to-use diagnostic strategy as a rational approach to the widening opportunities for the

17 This rational approach, applicable to other coagulation disor

18 These novel insights offer rational approaches for more selective and therefore mor

19 ly have important implications for designing rational approaches to early intervention.

20 Rational approaches to the case management of cholera wi

21 Exact simplex solvers based on rational arithmetic require a near-optimal warm start to

22 The rational assembly of various nanocrystal systems into no

23 hese two apoptosis regulators and provides a rational basis for clinical testing of this therapeutic

24 nefits of MR antagonism in the pig provide a rational basis for future clinical trials assessing the

25 his model of EV-D68-associated AFM provide a rational basis for selecting empirical therapy in humans

26 ncluding the activation of PPP and provide a rational basis for targeting this gene network for radio

27 ti-diabetic drug discovery; and b) provide a rational basis for the development of future pharmacolog

28 The identified compounds provide a rational basis to initiate the design and chemosensory a

29 unambiguously demonstrating the hallmark of rational behaviour, transitivity.

30 ed, rendering necessary procedures for their rational benchmarking and fueling the quest for leading

31 l catalysis regime is a prerequisite for the rational benchmarking of molecular electrocatalysts that

32 The rational bottom-up synthesis of atomically defined graph

33 s in LC patients, providing an anti-fibrotic rational by enhancing NK cell activity.

34 Radiotherapy is a rational candidate for combining with BCL-2 inhibition,

35 ome in activated immune cells have made it a rational candidate for the targeted treatment of immune-

36 lysts and substrates provide a framework for rational catalyst design that can accommodate a broader

37 According to rational choice theory, beneficial preferences should le

38 These rational choices are associated with direct benefits, en

39 This suggests a mechanism for making rational choices despite the potential bias.

40 n materials design can now be enabled by the rational combination of Machine Learning methods and mat

41 The rational combination of plasmonic nanoantennas with acti

42 Furthermore, these data support rational combinations of hypomethylating agents with SMO

43 r disease-modifying activity is limited, and rational combinations with other targeted agents are nee

44 nd this adaptive response and thereby design rational combinatorial approaches.

45 nisms can be obtained, which may lead to the rational control of active TiO2 (001) and (101) facets f

46 This lays ground rules for rational control of membrane proteins in nanotechnology

47 or highly efficient electrocatalysts by more rational control over the size, shape, composition, and

48 al buffer resistance-based correction, (iii) rational cooling adjustment, (iv) elimination of the non

49 This new understanding permits the design of rational cytokine and intracellular signaling pathway-ta

50 phenomenon may lead to actions aimed at more rational decision making and may contribute to lowering

51 .SIGNIFICANCE STATEMENT Standard theories of rational decision-making assume context-independent valu

52 ty that in humans is considered as optimal, "rational" decision-making.

53 al decision-making tasks, humans often make "rational" decisions, where they maximize expected reward

54 ethane storage capacities, highlighting that rational defect engineering can be an effective method t

55 Thus, membrane self-assembly showed rational dependence on fundamental mineral properties.

56 porous immobilization supports, facilitating rational design (immobilization method, geometry, enzyme

57 interaction and can be a useful tool for the rational design also of G4 ligands.

58 We employ rational design and a toxin/antitoxin titering approach

59 This report describes the rational design and characterization of expanded-spectru

60 of photosynthetic membranes is essential for rational design and construction of artificial photosynt

61 and are regarded as ideal blueprints for the rational design and construction of metal-organic framew

62 g would provide an informative framework for rational design and could lead to potential antimicrobia

63 We demonstrate rational design and fabrication of hierarchical In2S3-Cd

64 Here, we describe the rational design and implementation of a genetically enco

65 The rational design and implementation of enantiodivergent e

66 wledge of these systems is required to allow rational design and morphological engineering.

67 n, which is helpful to the cathode materials rational design and practical applications of Li-S batte

68 teins and then review recent progress in the rational design and preclinical testing of small molecul

69 blished for some of the COF materials toward rational design and rapid screening of the best electroc

70 ist, NBD-11021, we present in this study the rational design and synthesis of 60 new analogues and de

71 Here we report the rational design and synthesis of a double perovskite PrB

72 nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprisi

73 eutical properties is usually carried out by rational design and/or directed evolution.

74 These promising results suggest that a rational design approach can be used to generate an effe

75 Through a rational design approach we discovered a highly selectiv

76 nctional switch, and is the first example of rational design in which a small molecule is used to tri

77 er, these results suggest a strategy for the rational design of 2D chemical interfaces in which the p

78 Herein, we report the rational design of a broadly applicable Pd-catalyzed met

79 A rational design of a catalyst can be guided by identifyi

80 s could prove to be a tunable feature in the rational design of a catalyst.

81 yngas compositions: we therefore pursued the rational design of a family of electrocatalysts that can

82 tudies and computational modeling led to the rational design of a multifunctional catalyst that enabl

83 This has been achieved by rational design of a small pi-conjugated thiolated molec

84 Vdelta2 T cell subset may be included in the rational design of a TB vaccine or host-directed therapy

85 archetypal IDP sequences and demonstrate the rational design of a vast library of multicomponent prot

86 Here, we present the rational design of a wax-printed 3D-muPAD that enables m

87 experimental contributions have enabled the rational design of active sites.

88 molecule synergistic interactions allows the rational design of additional combinations that bypass d

89 indings provide a molecular basis for future rational design of agents that interfere with the initia

90 loop swapping is an attractive route to the rational design of an antibody targeting a pre-selected

91 esent a proof-of-concept application for the rational design of an epitope-specific antibody binding

92 during natural infection can help guide the rational design of an HIV vaccine.

93 n the arsenal of viruses and may lead to the rational design of antiviral agents.

94 tosynthesis in these organisms and informing rational design of artificial light-harvesting systems.

95 The rational design of biomolecules is becoming a reality.

96 for structural analysis, model building and rational design of biomolecules.

97 9 transition metals and pave the way toward rational design of C-H functionalization catalysts.

98 nucleobases and the structural basis for the rational design of C-HgII-T or T-HgII-T containing DNA n

99 e the nature of active sites and improve the rational design of catalysts.

100 Moreover, we show the importance of the rational design of channels on these devices using gluco

101 cancer and treatment types and allows for a rational design of clinical trials.

102 Our results will help permit the rational design of complex new molecular materials in wh

103 e in silico These results can help guide the rational design of complex therapeutic interventions, wh

104 Rational design of conductive carbon hosts for high ener

105 s of cholera spread, which should inform the rational design of control measures for cholera in Afric

106 ternalization, and biodistribution through a rational design of corresponding analogs.

107 Our structure should inform rational design of countermeasures against HCMV, other h

108 d protection, providing guiding tools to the rational design of cryoprotectant containing nano formul

109 ificity translates into a direct path to the rational design of donor and acceptor compounds which di

110 The rational design of drug delivery approaches leveraging s

111 s expands the space of opportunities for the rational design of drug polypharmacology.

112 These results may aid in the rational design of drugs containing the difluoromethyl m

113 l, our study represents a novel approach for rational design of early-life vaccines.

114 This strategy represents a rational design of efficient electrocatalysts through fi

115 nct conformational states to be used for the rational design of functionally selective ligands that m

116 he physiology of these receptors and for the rational design of GPCR-targeted drugs.

117 Rational design of high efficient and low cost electroca

118 The rational design of high-performance devices requires a d

119 modelling and quantum dynamics to guide the rational design of higher-order synthetic circuits consi

120 Rational design of highly efficient bifunctional electro

121 e changes, providing a powerful tool for the rational design of immune therapies.

122 omplex, thus representing a step towards the rational design of immunogens and drugs inhibiting HCV e

123 titubercular activity were exploited for the rational design of improved analogues.

124 (and synthetic) nitrogen fixation and to the rational design of improved synthetic N2 fixation cataly

125 e devised a protein engineering strategy for rational design of inhibitors for DUBs and other UPS pro

126 nvestigation on high-capacity electrodes.The rational design of intercalation electrodes is largely c

127 h predictive understanding is needed for the rational design of intervention strategies to actively c

128 study thus represents a new paradigm for the rational design of ionophores that can rapidly and preci

129 eract with their substrates is necessary for rational design of IP modulators.

130 ZNPs provide a chemical guide for rational design of long RNA carriers, and represent a pr

131 ransfer and provide vital principles for the rational design of long-coherence electronic qubits.

132 A scaling theory allows for the rational design of LSMAs to sort and array particles on

133 Our approach enables rational design of materials with targeted crystal symme

134 We report the rational design of metal-organic layers (MOLs) that are

135 cidating the EP effect are important for the rational design of microfluidic devices and impedance se

136 In this context, a rational design of mitochondriotropic antioxidants (comp

137 e insights gained from this study can inform rational design of modular heteromultivalent nanoparticl

138 sinonasal system and the lung may guide the rational design of more effective therapeutic strategies

139 e and "Molecular economical" strategy in the rational design of multifunctional nano-theranostic syst

140 refore provides a promising approach towards rational design of multifunctional, elastic SEIs that ov

141 The rational design of nanomedicines is a challenging task g

142 are provided on the emerging concept of the rational design of NEs and recent technological breakthr

143 s on Zr-based MOFs open new opportunities in rational design of new and superior decontamination mate

144 ng of the FRET-based biosensor and guide the rational design of new biosensor constructs.

145 A critical step toward the rational design of new catalysts that achieve selective

146 rovide a unique structural component for the rational design of new DNA nanodevices.

147 from the descriptors provide an approach for rational design of new electrocatalysts for both clean e

148 concrete feature that can be utilized in the rational design of next-generation organophosphate hydro

149 I) represents an important example where the rational design of next-generation probiotics is being a

150 pathway as a potential leverage point in the rational design of novel adjuvants.

151 ydrides with tailored properties towards the rational design of novel functional materials.

152 rties of Wee kinases and a framework for the rational design of novel inhibitors thereof.

153 echanisms in KR2 may provide a basis for the rational design of novel light-driven ion pumps with opt

154 e that this information could facilitate the rational design of novel long-acting A2A agonists with i

155 uires a systems engineering approach for the rational design of optimized carriers that have a realis

156 ent work, may open new opportunities for the rational design of other 3D transition-metal-based elect

157 metabolic pathways is indispensable for the rational design of plant and microbial systems for the p

158 and these insights can be used to guide the rational design of polymer-coated smart nanopores.

159 of transition state features can enable the rational design of potent inhibitors.

160 oxygen reduction in acidic electrolyte, the rational design of sacrificial metal-organic frameworks

161 nd it provides predictive guidelines for the rational design of selective carbon-based CO2 reduction

162 this promiscuity invites the possibility for rational design of sequences optimized for strand bindin

163 formation of FePYR1 would also assist future rational design of small molecules targeting specific AB

164 knowledge of these pathways may lead to the rational design of small molecules that modulate aging a

165 cranial stimulation, this study will aid the rational design of stimulation protocols for the treatme

166 strategy offers a versatile approach to the rational design of strongly coupled excitonic circuits u

167 dimycolate (TDM), has opened avenues for the rational design of such molecules.

168 The obtained results provide means for the rational design of surface-confined supramolecular archi

169 Our findings enable rational design of synthetic donor DNAs for efficient ge

170 ene circuit behaviours and also benefits the rational design of synthetic gene networks.

171 wever, realizing this complex process by the rational design of synthetic molecules or macromolecules

172 study elastic gridshells with a focus on the rational design of the final shapes.

173 us membrane fusion is expected to inform the rational design of therapeutic and prevention strategies

174 Through rational design of training and validation sets, key dia

175 Our model can be used as a tool in the rational design of treatment for bacterial infections.

176 Herein we report a rational design of uGFPc toward an unprecedentedly high

177 during infection, which may be useful in the rational design of vaccines directed against pathogens a

178 approach that provides a promising route for rational design of variety of sensor devices for LPG det

179 theoretical analysis that enables a precise, rational design of various optical Janus structures with

180 ron-transfer dynamics are poorly understood, rational design rules for improving activity remain uncl

181 te model compounds, which are synthesized by rational design to incorporate systematic variations, ca

182 g novel 2D and 3D auxetic structures through rational design, optimization, and taking inspiration fr

183 Using rational design, we adapted a validated 8-N-benzyladenos

184 y on these receptors that were discovered by rational design.

185 y structural classification that could allow rational design.

186 inhibitor scaffolds by improved screening or rational design.

187 The key features include rational designing and sustainable synthesis of the temp

188 ructure-activity relationships and promoting rational designs of catalysts.

189 These results will inform the rational development of 2D COF polymerizations by contro

190 We anticipate that rational development of drugs targeting molecular chaper

191 A main obstacle in the rational development of heterogeneous catalysts is the d

192 Ps) with serum proteins is necessary for the rational development of nanocarriers.

193 Here we describe the rational development of new molecules with powerful adju

194 may be utilized as a paradigm to aid in the rational development of other efficacious live attenuate

195 ore domain protein, which provides means for rational development of second-generation MINIs.

196 on of this gene can provide a target for the rational development of vaccines.

197 se the available starting scaffolds for both rational drug design and library selection methods.

198 modification and will aid a structure-guided rational drug design approach to treating multidrug-resi

199 some of the CYP51 key features important for rational drug design have remained obscure.

200 at alchemical free energy methods can assist rational drug design projects.

201 ncorporation and can provide information for rational drug design to help combat ASFV in the future.

202 the urgent need for new methods that enable rational drug design.

203 Finally, we consider the implications for rational drug development, in particular regionally sele

204 longer-term use and highlights the need for rational drug development.

205 Here, we exploit this approach to develop a rational drug discovery strategy against Abeta42 aggrega

206 d structural studies provide a framework for rational engineering aimed at altering catalytic functio

207 We used rational engineering and age- and species-specific model

208 ation of the HNH domain can be exploited for rational engineering of Cas9 variants with enhanced spec

209 ease responses, allowing for more efficient, rational engineering of crops that are more robust or re

210 These results may guide the rational engineering of multilayer and core-shell oxide

211 the possibility of using yeast to accelerate rational engineering of nonribosomal peptide antibiotics

212 ion era in microbiome research and lead to a rational evaluation of clinical strategies relevant for

213 The rational evolution of a mechanism-based strategy that le

214 analysis with molecular modelling provides a rational explanation, demonstrating that Glu and Arg for

215 r reported for this amino group, providing a rational for the observed need for a general base in the

216 ressive CLL models and provide a preclinical rational for the use of PARP inhibitors in ATM-affected

217 ctivity in our omega-3 metabolic engineering rationales for Camelina.

218 c thresholds of prior drug exposure to guide rational ganR-CMV testing in SOT recipients.

219 oviding the first step in the development of rational guidelines for patient-specific diagnostics and

220 pre-organoids, respectively, thus providing rational guidelines towards establishing a robust protoc

221 olved in pleuromutilin biosynthesis, through rational heterologous expression in Aspergillus oryzae c

222 mine evolutionary distances for the basis of rational hierarchal classifications.

223 These are essential parameters for the rational improvement of a MASER based on a spin-polarize

224 stems, while requiring advanced analysis for rational improvement.

225 , positive and negative problem orientation; rational, impulsiveness/carelessness, and avoidance prob

226 Is human vision rational in this way?

227 RATIONAL: In Japan patients with Japanese Cedar (JC) pol

228 Iterative cycles of rational inhibitor design and biophysical characterizati

229 l spring-loaded activation mechanism through rational insertion of the light-sensitive LOV2 domain th

230 These results demonstrate that the rational integration of nanomaterials could be a fruitfu

231 Rational investigation, including spinal MRI, nearly alw

232 o address this challenge, we now present the rational, iterative development of a general reaction-ba

233 assay development also provides a basis for rational lead optimization of this very promising class

234 ated from any AAV serotype, whether natural, rational, library derived or a combination thereof, prov

235 On the basis of rational ligand design, a new class of selective antagon

236 This offers opportunities for the rational manipulation of these complex non-covalent inte

237 ve fluorescent probes has been designed in a rational manner with the aid of quantum chemistry tools,

238 ndantly in mate detection and assessment, as rational mate choice largely persists when visual or che

239 A rational mechanistic pathway is presented based on DFT a

240 bles facile insertion and deletion of genes, rational modification of gene expression, and testing of

241 Rational modulation of the immune response with biologic

242 lights that constructing PHJs and adapting a rational molecular design of PHJs are effective strategi

243 strongly predicts that people will behave as rational observers and in many cases social perception s

244 goal to find out which designs are the most rational ones for highly sensitive detection of OTA.

245 es a foundation for a general method for the rational overexpression of integral membrane proteins ba

246 c pocket provides a new and novel target for rational P2X7R drug development.

247 Here we demonstrate the combination of rational peptide array library design, parallel screenin

248 e processes, paving the way for a new era of rational piloting of the gut microbiome functions, throu

249 ly stabilize unravelling among a majority of rational players.

250 that have worked against a comprehensive and rational policy for regulating toxic chemicals and discu

251 ential for both appropriate clinical use and rational policy making.

252 tases (NRPSs) and lay the groundwork for the rational reengineering of NRPSs by swapping domains hand

253 Thus, rational removal of ssDNA exonucleases may be broadly ap

254 PVR might be treated by rational repositioning of existing drugs that target mTO

255 tal role was permitted by the development of rational sampling, point-of-care tests, and extended aut

256 graphs from the DCCT/EDIC study to develop a rational screening frequency for retinopathy.

257 periments provide a proof-of-principle for a rational search for pharmacochaperones, which may be use

258 ents suspecting of having reflux, leading to rational selection of treatment and better outcomes.

259 her, our results have broad implications for rational selection of vaccine strains that do not contai

260 Upon rational selection/design of quinone structures, we demo

261 Recent developments of rational strategies for the design of antiviral therapie

262 A rational strategy to achieve this end is to determine in

263 n of Bax activation and mTOR inhibition as a rational strategy to improve lung cancer treatment.

264 This, in effect, enables the generation of a rational strategy to improve the delivery efficiency of

265 these findings provide a proof-of-principle, rational strategy to target the MYB "addiction" of Ph(+)

266 gn and optimization of peptidic catalysts by rational structural modifications is difficult.

267 mapping for hot spot identification to guide rational structure-based design and NMR screening of foc

268 on process was the successful application of rational structure-based drug design to address bromodom

269 Rational surface engineering of 2D nanoarchitectures-bas

270 ly-stage invasive cancer will help formulate rational surveillance guidelines and allow us to divest

271 The first rational synthesis of a BN-doped coronene derivative in

272 tructure-activity relationship and promote a rational synthesis of X-ray amorphous IrOx hydroxides th

273 These results have implications for rational tailoring of substrate tolerance in sortases.

274 Overall, our results highlight EZH2 as a rational target for therapeutic intervention in sunitini

275 toward future clinical trials incorporating rational targeted agents into the therapeutic armamentar

276 eins, protein and metabolic engineering, and rational techniques for immobilization, have become avai

277 ediment to plastid transformation provides a rational template to implement plastid transformation in

278 hanism and the reaction kinetics enables the rational, template-free synthesis of ssDNA that can be u

279 that targeting Cbx3/HP1gamma can represent a rational therapeutic approach to control growth of solid

280 Rational therapeutic approaches based on synthetic letha

281 , our findings suggest HDAC6 inhibition is a rational therapeutic strategy to be implemented in combi

282 illnesses, and the ER blockade represents a rational therapeutic strategy.

283 ding of NPC biology, disease progression and rational therapy design.

284 one of which emphasized abstract, idealized, rational thinking and the other, which emphasized the em

285 I agree it is rational to rely on stereotypes, but in the complexity o

286 and assert that perceptions are ecologically rational to the degree that they adapt to the social rea

287 ain micro-metastasis detection or for making rational treatment decisions and monitoring therapeutic

288 (NF2), their pathogenic etiologies, and the rational treatment options for people with these neoplas

289 ion of 3-substituted azetidine groups allows rational tuning of the spectral and chemical properties

290 In particular, distinct molecular rationales underlie the distinct evolutionary behavior o

291 r cells, is fascinating and passes through a rational understanding of the ligand/G4 interaction.

292 objective risk stratification is needed for rational use of advanced therapies such as mechanical ci

293 eloping BSI is a promising method of guiding rational use of empiric anti-VRE antimicrobial therapy i

294 e repertoires with potential applications in rational vaccine design and immunotherapeutics.

295 e experimental validation for the concept of rational vaccine design from genomic sequence data.

296 immune system provide important targets for rational vaccine design.

297 nscriptome data has the potential to advance rational vaccine development but yet there are no licens

298 erpinnings of such features is essential for rational vaccine development.

299 e has been no framework to achieve this in a rational way.

300 g the structural and dynamic investigations, rationales were developed for the stabilizing effect at