ライフサイエンスコーパス: regulatory

1 Concern about regulatory acceptance was the most commonly cited factor

2 e, we have used mouse liver CRMs involved in regulatory activities of the hepatic TR, NR1H4 (FXR; far

3 s for which the two alleles confer different regulatory activities.

4 p a gene editing approach to investigate the regulatory activity of 3'-UTRs in their native context.

5 We tested the cis-regulatory activity of 69 TE subfamilies by luciferase r

6 ys demonstrated that rs9920291 shows allelic regulatory activity, and CRISPR/Cas9 targeting of human

7 Regulatory agencies are considering non-abstinent outcom

8 mmunology (EAACI), experts from academia and regulatory agencies met with chamber operators to list t

9 fore their marketing or formal approval from regulatory agencies, and for this reason their efficacy

10 utical ingredients approved by FDA and other regulatory agencies.

11 e editing of promoters generates diverse cis-regulatory alleles that provide beneficial quantitative

12 ow the multifunctional nature of these HIV-1 regulatory and accessory proteins, and in particular the

13 y mechanisms that affect the balance between regulatory and effector T cells.

14 However, the regulatory and functional relationships between Twist1 a

15 IL-12p40 while enhancing the release of the regulatory/anti-inflammatory cytokine IL-10.

16 of a formal national clinical registry since regulatory approval in March 2015, we obtained procedura

17 se tumorigenesis is a complex mechanism, the regulatory architecture of the immune system is likely t

18 mmatory T cell response while increasing the regulatory arm of the immune response in animals models

19 lids emissions simultaneously and performing regulatory assessments that account for spatial variatio

20 thors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to li

21 c subunit VPS34, the VPS15 scaffold, and the regulatory BECN1 and ATG14 subunits.

22 ator ULK1 phosphorylates beta1-Ser108 on the regulatory beta1-subunit, sensitizing AMPK to allosteric

23 Critically, the sterol regulatory binding protein 1 and its targets are key int

24 k and holm oak outer bark, which unveils new regulatory candidate genes of phellem development.

25 inhibition could reduce cellular complement regulatory capacity.

26 to decipher various molecular aspects of the regulatory cascade that causes chronic infection.

27 oss of total and memory B cells, increased B regulatory cell [Breg] counts, and B cell activation and

28 -like memory B cells, and expansion of the B regulatory cells (Bregs).

29 whether their function is coordinated with T regulatory cells (Tregs).

30 CD3(+) alphabeta TCR(+) cells and Foxp3(+) T regulatory cells were present in DKO mice but significan

31 nctional, Mtb DosR latency antigen specific, regulatory, central memory response is therefore a novel

32 MCHD1 mRNA or protein abundance but revealed regulatory changes in genes and pathways associated with

33 Thus, we show that a fraction of gene-regulatory changes suggest strong mechanistic hypotheses

34 Our results indicate that VSG induces global regulatory changes that impact hepatic inflammatory and

35 expression of INO1 via the Opi1p/Ino2p-Ino4p regulatory circuit.

36 Human-specific regulatory circuitry of DLX5 might help explain certain

37 These findings accentuate the regulatory complexities of bacterial response to antimic

38 Functional regulatory compliant tissue-engineered corneal endotheli

39 gy initiation complex (AIC) and the upstream regulatory components LKB1 and AMPKalpha, which regulate

40 Future regulatory design will minimize compliance costs and HEC

41 specific changes in pathway networks and the regulatory disruptions related to genomic aberrations in

42 We demonstrate the existence and regulatory divergence of many LORe ohnologues with funct

43 ind that a RUNX1 domain, termed the negative regulatory domain for DNA binding, can compensate for th

44 Collectively, our results unmasked the regulatory dominance of the melanophilin adaptor protein

45 ation and thrombosis, followed by changes in regulatory ECM proteins.

46 These studies provide new insights into the regulatory effect exerted by JMJD2B on tumor growth thro

47 The critical regulatory effect of phosphorylation is shown by replace

48 cell line as a model of HE, we explored the regulatory effect of platelets.

49 et of BCL6 in GBM and mediates partially the regulatory effects of BCL6 on both MEK-ERK (mitogen-acti

50 e genome-engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regula

51 Thus, CATAC represents a novel cis-regulatory element encoding clock-controlled regulation.

52 nse element consensus sequence in the sterol regulatory-element binding protein-1c (Srebp-1c) promote

53 be a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly ide

54 their influence through rearrangement of cis-regulatory elements (CREs) remains unclear.

55 The regulatory elements and the environmental signals contro

56 nucleus involving gene promoters and distal regulatory elements are currently considered major force

57 Millions of cis-regulatory elements are predicted to be present in the h

58 r genomics efforts have identified genes and regulatory elements driving cancer development and neopl

59 We sequenced coding and regulatory elements for 608 genes potentially involved i

60 Epigenetic and genetic cis-regulatory elements in diploid organisms may cause allel

61 at erosion of X. laevis genes and functional regulatory elements is associated with repeats and non-a

62 q and found that unlike the naive cells, the regulatory elements of the cytokine genes in the memory

63 Changes in the cis-regulatory elements of these regulators are thought to c

64 n transcriptional promoters and their distal regulatory elements play an important role in transcript

65 tion factors interact to select and activate regulatory elements that control microglia development a

66 Large regulatory elements, so-called super-enhancers (SEs), ar

67 s of tissues or cells, e.g. lineage-specific regulatory elements.

68 Myelin-gene Regulatory Factor (MyRF) is one of the master transcript

69 caffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) interacts with the calcium

70 In this study, we report that IFN regulatory factor 4 (Irf4) is highly expressed in murine

71 Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional det

72 tein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI) that contain receptor-interacti

73 ation for understanding the role of multiple regulatory factors in modulating Fshb gene activity.

74 h vessel patterning might involve modulatory regulatory factors such as R-spondin 1 (Rspo1), an extra

75 d, and that RctB may have evolved additional regulatory features.

76 Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of

77 , transcriptome, and proteome; and a complex regulatory feedback network between free methyl groups a

78 These results suggest that the regulatory foundation for spatiotemporal gene expression

79 For decades, in most regulatory frameworks, recombinant DNA-modified organism

80 The transcriptional regulatory function of DDB2 is significant in colon canc

81 l role of Pik3r1 that was independent of the regulatory function of phosphoinositide 3-kinase in medi

82 pt levels in vts1Delta cells established the regulatory function of these binding sites.

83 o oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accou

84 provide new insights into understanding the regulatory functions of RBPs, including the binding effe

85 The identification of a stem cell regulatory gene which is aberrantly expressed in glioma

86 ring the cork growth season showed that most regulatory genes are upregulated early in the season whe

87 ation of metabolism is largely controlled by regulatory genes.

88 ing DNA accessibility of hypocotyl cell size regulatory genes.

89 link between disease-associated SNPs and the regulatory genome that will improve the functional inter

90 reflecting our limited understanding of cis-regulatory grammar and hampering the design of engineere

91 The iron-regulatory hormone hepcidin is induced early in infectio

92 prostate tumor samples indicated a stronger regulatory impact of structural variants, as they affect

93 ion of gametes, and the second restricts the regulatory influence of new insertions toward neighborin

94 propose a model where positive and negative regulatory influences at each promoter site are integrat

95 n dynamic network models of multi-organ gene regulatory influences.

96 rm for studying how evolutionarily distilled regulatory information commonly controls IEC development

97 The regulatory information encompassed in developmental GRNs

98 ng, potential mechanisms accounting for this regulatory interaction remain unexplored.

99 otential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface o

100 es use of prior biological knowledge on gene-regulatory interactions in order to increase robustness

101 Thus, regulatory interactions of evolutionarily recent sRNAs c

102 We studied the regulatory interactions operating within and across orga

103 rticipation in supramolecular complexes, and regulatory interactions) using CellDesigner software.

104 ent of the chloroplast import machinery, the regulatory kinase at the outer chloroplast membrane 1 (K

105 eats have also contributed to the p300-bound regulatory landscape following hybridization and whole-g

106 omyosin stress fibers (SFs) depend on myosin regulatory light chain (RLC) phosphorylation, which is d

107 ese foods were in all cases within permitted Regulatory limits of 500 or 1000microg.kg(-1) in fishery

108 onstrated that DNMT1 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression incre

109 vessel normalization, indicating a mutually regulatory loop.

110 n in cancer, it remains unknown whether such regulatory loops operate also in non-transformed cells.

111 his BBX32-COL3 module could be an additional regulatory mechanism affecting the reproductive developm

112 from durum wheat and demonstrate the unique regulatory mechanism by which Iw1 acts to suppress a car

113 elevating mitochondrial cristae density as a regulatory mechanism for increasing metabolic power in h

114 Our findings reveal a distinctive regulatory mechanism for the association of paired reade

115 enrichment at oncogenic enhancers is a novel regulatory mechanism in human pancreatic cancer.

116 To investigate the regulatory mechanism of mIDH2 (mouse mitochondrial IDH2)

117 Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros

118 e MT1-MMP cytoplasmic tail may function as a regulatory mechanism to impact ovarian cancer metastatic

119 Rainbow enhancers may represent a cis-regulatory mechanism to turn on a group of genes that ar

120 ng epidermal differentiation suggested a cis-regulatory mechanism via conserved noncoding elements or

121 ons and intestinal immune cells share common regulatory mechanisms and can coordinate their responses

122 in the Hsp70 proteins are linked with their regulatory mechanisms and cellular functions.

123 allergic airway inflammation and to address regulatory mechanisms and clinical relevance in normal h

124 In this study, we report three regulatory mechanisms contributing to the specificity of

125 h it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer

126 However, the regulatory mechanisms controlling IF dynamics and organi

127 roposed to stem from disruption of conserved regulatory mechanisms evolved during the transition to m

128 Transcriptional programming of regulatory mechanisms facilitates the functional activat

129 PPI hubs reveal new regulatory mechanisms for cancer genes like MYC, STK11,

130 d possibly its function(s) are controlled by regulatory mechanisms involving crosstalk between differ

131 what are conventionally considered negative regulatory mechanisms of olfactory transduction also pla

132 Previous work has elucidated the regulatory mechanisms of p300 acetyltransferase activity

133 her, these results provide new insights into regulatory mechanisms of seed vigor and reveal distinct

134 The stochastic dynamics and regulatory mechanisms that govern differentiation of ind

135 owever, knowledge about the dynamics and the regulatory mechanisms underlying nuclear movements in ro

136 wever, it is unknown how the transcriptional regulatory mechanisms underlying these functions have ch

137 Our findings illuminate core regulatory mechanisms unique to the early Golgi Arf-GEFs

138 To clarify the underlying regulatory mechanisms, we developed three biologically a

139 and the second monomer exhibiting disrupted regulatory metal coordination in an open non-DNA-binding

140 odimer, with one monomer displaying complete regulatory metal coordination in the characteristic cali

141 r, these findings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstrea

142 but likely reflects a linear arrangement of regulatory molecules.

143 ivator, their interaction network presents a regulatory motif characteristic of a "feedback-amplified

144 Target genes of a cis-regulatory motif were identified from the network via th

145 ed intronic sequences harboring distinct cis-regulatory motifs, constitute much of cell-type-specific

146 Here, we show that the regulatory N-terminal residues and the EH domain keep th

147 of these four TFs and PHO1;H3 in a new gene regulatory network controlling phosphate accumulation in

148 we developed an algorithm called GRACE (Gene Regulatory network inference ACcuracy Enhancement).

149 To improve the accuracy of gene regulatory network inference and facilitate candidate se

150 a strategy to rewire the endogenous cellular regulatory network of yeast to enhance compatibility wit

151 We define an IEC transcriptional regulatory network that is shared between fish and mamma

152 The failures in the gene regulatory network that lead to cancer are abstracted as

153 disease-associated mutations may perturb the regulatory network through diverse mechanisms including

154 illustrates the elasticity of the bacterial regulatory network, which can be rewired by a single sub

155 se are linked to genes in the pluripotential regulatory network.

156 l behavior is ultimately the product of gene regulatory networks (GRNs) for brain development and neu

157 es that have restructured developmental gene regulatory networks (GRNs).

158 Innovative approaches combining regulatory networks (RN) and genomic data are needed to

159 Modeling of transcriptional regulatory networks (TRNs) has been increasingly used to

160 tent to which cell- and tissue-specific gene regulatory networks are established.

161 impedes the construction of larger synthetic regulatory networks as leak propagation can interfere wi

162 ssess distinct chromatin landscapes and gene regulatory networks associated with tumorigenesis and EM

163 These findings demonstrate that host AIC regulatory networks confer susceptibility to infection a

164 For example, transcriptional regulatory networks consist of interactions among protei

165 at ancient paralogues can remain in the same regulatory networks for dozens of millions of years.

166 the chromatin landscape and Blimp1-dependent regulatory networks governing trophoblast gene expressio

167 gy enables perturbation of the metabolic and regulatory networks in a modular, parallel, and high-thr

168 ally expressed genes was used to reconstruct regulatory networks involved in differentiation.

169 The evolution of RNA-protein regulatory networks is far less understood.

170 a and to build predictive models of the gene regulatory networks that drive the sequence of cell fate

171 approaches are commonly used to identify key regulatory networks that drive transcriptional programs.

172 Regulatory networks that include the Gata2 transcription

173 in breast cancer cells direct critical gene regulatory networks that promote pathogenesis.

174 ll types relevant to pathophysiology and the regulatory networks underlying disease.

175 To fully understand gene regulatory networks, it is therefore critical to accurat

176 dissemination and targeted interventions in regulatory networks, to the development of mitigation po

177 teins, which implies extensive translational regulatory networks.

178 us relate the structure and function of gene regulatory networks.

179 n illuminate components of TF-dependent gene regulatory networks.

180 d that miR172-AP2, miR156-SPLs were critical regulatory nodes contributing to the diversity of double

181 osuppressive characteristics: T cells with a regulatory or an exhausted phenotype and macrophages wit

182 gnature a prime target in the search for the regulatory origins of T cell dysfunction in chronic vira

183 PilB functions as an intermediary in the EPS regulatory pathway composed of the T4P upstream of the D

184 tion of the complement system and respective regulatory pathways, with concordant findings at the pro

185 e intriguing possibility of undiscovered NMD regulatory pathways.

186 ffects on gene transcription and non-genomic regulatory pathways.

187 the cell, including important signaling and regulatory pathways.

188 e conclude that VP1 is a novel streptococcal regulatory peptide that controls biofilm development and

189 ugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for ac

190 ed CD4(+) naive T cell polarization toward a regulatory phenotype and impaired CD8(+) T cell allo-rea

191 h repeat protein phosphatase 1 (PHLPP1) as a regulatory phosphatase that facilitates proper kinetocho

192 sms age, the circadian system shifts greater regulatory priority to the mitigation of accumulating ce

193 profile time-varying biological signals and regulatory programs remains limited.

194 rigidity and plasticity over transcriptional regulatory programs.

195 Regulatory properties of the lead risk variant region we

196 dels toward an understanding of the system's regulatory properties.

197 Here we have shown that CD47-signal regulatory protein alpha (SIRPalpha) axis dictates the f

198 n transducing signals through primate signal regulatory protein alpha.

199 lular assembly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, A

200 roduction of each inhibitor is promoted by a regulatory protein that is itself inhibited by the cell-

201 The inhibitory receptor signal regulatory protein-alpha (SIRPalpha) is a myeloid-specif

202 In the brain, transmembrane AMPAR regulatory proteins (TARPs) critically influence the dis

203 nical Galpha, this rate could be affected by regulatory proteins in the presence of specific signals,

204 olled by the combinatorial action of several regulatory proteins.

205 a sarcomere, such as filament stiffness and regulatory proteins.

206 pression changes in key ion transporters and regulatory proteins.

207 mputational tools fail to reliably determine regulatory region accessibility from the analysis of the

208 ta resources include evidence-based gene and regulatory region annotation, genome variation and gene

209 of the expansion segment 7 (ES7), a putative regulatory region located on the surface of the 60S ribo

210 redoxin-binding domain, along with a central regulatory region that links the two.

211 We surveyed the Gdf5 locus for regulatory regions in transgenic mice and fine-mapped se

212 they are not designed to identify individual regulatory regions mediating risk or the genes under the

213 genomic variation, especially in non-coding regulatory regions of human genome.

214 by binding to TH response elements (TREs) in regulatory regions of target genes.

215 and histone methylation marks identified DNA regulatory regions within the Cd44, Cdkn1a, and Cdkn2b g

216 for high-throughput screening of genes, gene regulatory regions, and long noncoding RNAs.

217 l enrichment of disease risk alleles on gene regulatory regions, they are not designed to identify in

218 sing H3K27me3 deposition at critical genomic regulatory regions.

219 t effect on pseudogene formation and loss of regulatory regions.

220 ese data across monkeys and humans support a regulatory relationship between the OT and opioid system

221 iceAntherNet) that allows prediction of gene regulatory relationships during pollen development.

222 identify new cytoskeletal configurations and regulatory relationships that orchestrate neuronal delam

223 stered nanoparticles was prepared to satisfy regulatory requirements for nasal dosage forms and the p

224 Enhanced and standardized regulatory requirements for reporting spills could impro

225 and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.

226 cal systems affect apical end points used in regulatory risk assessments, and without mechanistic dat

227 y translational applications for these small regulatory RNAs in AML.

228 boswitches are a widely distributed class of regulatory RNAs in bacteria that modulate gene expressio

229 These results establish a regulatory role for BCAT1 in macrophage function with th

230 We uncover a dual regulatory role for chromatin during DNA replication: pr

231 rs and mutants, provided insights into their regulatory role in defined modules of the JA network.

232 lude that nucleoporins play an unanticipated regulatory role in NEBD, by recruiting PLK-1 to the NE t

233 Vasopressin receptors appear to have a regulatory role in stress, anxiety, and alcohol.

234 f holo-ACPP in the cell identify a potential regulatory role of ACPS in fatty acid biosynthesis.

235 try and replication and highlight a positive regulatory role of IFN-induced proteins in HIV-1 infecti

236 dent, we resolve the paradox, highlighting a regulatory role of telomeres in cancer.

237 ighted for an especially early and important regulatory role.

238 gion, suggesting that this region may play a regulatory role.

239 SOCS-3 and SOCS-4 appear to play regulatory roles in a number of keratinocyte and endothe

240 a current view of the enteric glia and their regulatory roles in gastrointestinal (GI) (patho)physiol

241 block, These findings confirm the important regulatory roles of AlucJHEH in A. lucorum and indicate

242 Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-spec

243 These findings, along with the well-known regulatory roles that SIRT1 plays in modulating both ana

244 Apart from their regulatory roles, they are also involved in the producti

245 RNAs and RNA-binding proteins with potential regulatory roles.

246 removal, respectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (

247 minants of differences in cis-regulation for regulatory sequences residing in episomes versus chromos

248 diverse array of conformations to respond to regulatory signals in signaling pathways.

249 ome and the DNA conformation can provide key regulatory signals.

250 ts on gene expression of rare genic CNVs and regulatory single-nucleotide variants and found that rea

251 t subsequently binds to UAS2 (a critical cis-regulatory site located approximately 600 base pairs dow

252 To identify regulatory sites during sex determination, we subjected

253 We found FXR to bind to regulatory sites of genes encoding these proteins in con

254 their transcriptome structure and output of regulatory small RNAs (sRNAs) are incompletely understoo

255 ent approaches to determine the potential of regulatory SNPs depend on inadequate knowledge of cell-s

256 The regulatory state of the thick filament also seems to con

257 cific DNA-binding protein Cep3 together with regulatory subunits Ctf13 and Skp1.

258 This hypersensitive regulatory switch is entirely dependent on the unique fl

259 n of mutational effects of a transcriptional regulatory system differs from the distributions of its

260 Today, we are faced with a regulatory system that, weakened by decades of limited r

261 environment through the use of two-component regulatory systems.

262 Follicular regulatory T (TFR) cells are a newly defined regulatory

263 munization primes responses characterized by regulatory T (Treg) cells and immunosuppression.

264 ase has been well characterized, the role of regulatory T (Treg) cells in the loss of tolerance to gl

265 requires the production of Foxp3-expressing regulatory T (Treg) cells in the thymus.

266 cluding activation of host immunosuppressive regulatory T (Treg) cells.

267 of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 i

268 regulatory T (TFR) cells are a newly defined regulatory T cell (Treg) subset that suppresses follicul

269 crophage infiltration and higher presence of regulatory T cell after ischemia-reperfusion injury.

270 olism, as were cytokine secretion levels and regulatory T cell numbers.

271 ells, and CD70 limits T cell expansion via a regulatory T cell-independent mechanism that involves ca

272 When regulatory T cells (2 x 106/mouse) were intravenously ad

273 ve failed to investigate the role of natural regulatory T cells (nTregs) on the mitigation of GvHD by

274 , had a lower percentage of CD4+CD25hiFoxP3+ regulatory T cells (P < .01), but higher proportions of

275 feration, the distinct metabolic features of regulatory T cells (Tregs) are less well established.

276 Regulatory T cells (Tregs) in skin preferentially locali

277 Recently, regulatory T cells (Tregs) were described as necessary f

278 ther short-chain fatty acids (SCFAs), induce regulatory T cells (Tregs).

279 a subset of these cells into CD4+CD25+FoxP3+ regulatory T cells (Tregs).

280 n while promoting the generation of Foxp3(+) regulatory T cells (Tregs).

281 2s by co-stimulatory molecules such as ICOS, regulatory T cells and by compounds such as nicotine.

282 demonstrated that soluble CD137 produced by regulatory T cells contributed to their autoimmune-suppr

283 inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their

284 PA treatment led to sustained suppression of regulatory T cells in the blood.

285 esults in a marked increase in the number of regulatory T cells in the ipsilateral limb.

286 ually repopulated the numbers of circulating regulatory T cells within the first 7 days after stroke,

287 ugh most tolerance-inducing regimens rely on regulatory T cells, we found that induction of tolerance

288 rogram inducing the accumulation of Foxp3(+) regulatory T cells, while decreasing the levels of Th17

289 and number of thymic and peripheral Foxp3(+) regulatory T cells.

290 in vitro that mainly drives lesions, but not regulatory T cells.

291 e immune response by modulating the effector/regulatory T ratio.

292 onstrates that Aspergillus fumigatus induces regulatory T-cells with a TH17-like phenotype.

293 T follicular regulatory (Tfr) cells control the magnitude and specifi

294 to gluten, their amount must not exceed the regulatory threshold levels.

295 s that jointly encompass many key phenotypic regulatory Type II MADS-box gene clades (SEP1, SQUA, TM8

296 er operators to list technical, clinical and regulatory unmet needs as well as the prerequisites for

297 Among them, 70 variants are regulatory variants for which the two alleles confer dif

298 w the importance of investigating non-coding regulatory variants when determining risk factors contri

299 REEP3 (vesicle trafficking) are enriched for regulatory variants, of which at least six (35%) alter t

300 ptional regulation, we uncovered significant regulatory variation in individual yeast cells, both bef