ライフサイエンスコーパス: regulatory gene

1 d in peripheral PG synthesis and in the gpsB regulatory gene.

2 ined triple genes: two pathway genes and one regulatory gene.

3 ing DNA accessibility of hypocotyl cell size regulatory genes.

4 ation of metabolism is largely controlled by regulatory genes.

5 that impinges on the transcription of growth-regulatory genes.

6 gnificant deregulation of central cell cycle regulatory genes.

7 d repressing transcription of key cell cycle regulatory genes.

8 e replication and transcription of important regulatory genes.

9 ng by fine-tuning the expression of temporal regulatory genes.

10 ctly regulating the expression of cell-cycle regulatory genes.

11 9 mRNAs, including those of uvrY and 9 other regulatory genes.

12 stinct clusters between antiviral and immune regulatory genes.

13 ific embryonic domains and affect particular regulatory genes.

14 92/101]) simultaneously carried the putative regulatory genes.

15 ormation between developmental processes and regulatory genes.

16 ctly orchestrated process involving multiple regulatory genes.

17 evelopment through the direct control of key regulatory genes.

18 ts a common theme of alteration in chromatin regulatory genes.

19 key stage- and tissue-specific developmental regulatory genes.

20 opoiesis and expression of key hematopoietic regulatory genes.

21 motifs in the promoters of key developmental regulatory genes.

22 ent is controlled by networks of interacting regulatory genes.

23 ion of the lethal of scute and tailup H-cell regulatory genes.

24 resource for the identification of candidate regulatory genes.

25 es and construction coordination networks of regulatory genes.

26 a repressive environment over the cell cycle regulatory genes.

27 e identification of candidate structural and regulatory genes.

28 lls revealed deregulation of many cell cycle regulatory genes.

29 e showed the down-regulation of inflammatory regulatory genes.

30 linked to the actions of recently identified regulatory genes.

31 ngly correlates with essential developmental regulatory genes.

32 te growth in part by suppression of negative regulatory genes.

33 oral ectoderm during cleavage, a sequence of regulatory gene activations occur within this territory

34 Mice deficient in the autoimmune regulatory gene Aire develop a spontaneous T-cell and ma

35 Dysregulated expression of PP(i) regulatory genes ALPL, ANKH, and ENPP1 was also correcte

36 rgets of both factors are enriched for other regulatory genes, although nonoverlapping sets of functi

37 rosses have provided tantalizing evidence of regulatory genes, although, to date, mapping resolution

38 nxiety-like behaviors, and changes in stress regulatory gene and protein hormone levels were evaluate

39 en of the 42 eQTLs associated with 19 master regulatory genes and 29 downstream gene sets (n>30) were

40 which modulate the expression of key cancer regulatory genes and functions.

41 ure on activation and suppression of certain regulatory genes and gene networks, our study demonstrat

42 es required for biofilm formation, including regulatory genes and genes for matrix production.

43 nges, with strong upregulation of cell cycle regulatory genes and genes functioning in the Notch inte

44 the level of individual connections between regulatory genes and highlight how morphological novelty

45 lecule inhibition of VprBP reactivate growth regulatory genes and impede tumor growth.

46 stream regulation of the network, downstream regulatory genes and key morphoregulatory genes are depl

47 and has aided in the discovery of key growth regulatory genes and microRNAs (miRNAs) that have a role

48 ere I report spatiotemporal patterning of 55 regulatory genes and perturbation analyses of key regula

49 neural plate border, expresses a core set of regulatory genes and produces a diverse array of cell ty

50 f a small number of smoking-modified, master-regulatory genes and suggest a central role for altered

51 shed intercellular distribution of expressed regulatory genes and techniques both developed and appli

52 ted by NF-Y to these promoters of cell cycle regulatory genes and that SOX9 is critical for the full

53 ty against insect herbivores; however, major regulatory genes and the signals that modulate these def

54 ants that had inserted within or adjacent to regulatory genes and thereby caused increased expression

55 Overall, OsMADS1 binds to several regulatory genes and, probably in combination with other

56 The expression of SMR7, a cell cycle regulatory gene, and ERF115 and PSK5, regulators of QC d

57 erentiate or efficiently up-regulate lineage-regulatory genes, and eventually fail to sustain for lon

58 ogenicity locus (PaLoc), which also contains regulatory genes, and is absent in non-toxigenic strains

59 l might affect expression or function of SAM regulatory genes, and we found WUSCHEL (WUS) expression

60 ulatory networks, offering opportunities for regulatory gene annotation.

61 a more accessible system, and many important regulatory genes appear to function similar to zygotic d

62 In contrast, no endoderm regulatory genes are activated by Delta signaling even d

63 As many cell cycle regulatory genes are essential in C. crescentus, the ess

64 All NSM specific regulatory genes are henceforth expressed exclusively, i

65 totic cells uncovered that key hematopoietic regulatory genes are occupied by GATA1 in mitosis.

66 Interestingly, the early developmental regulatory genes are often located in large genomic doma

67 ranscription and that several key antibiotic regulatory genes are translationally induced at transiti

68 ring the cork growth season showed that most regulatory genes are upregulated early in the season whe

69 The upstream regulatory genes are usually the first to be identified,

70 ed on KEGG pathway showed that metabolic and regulatory genes associated with energy metabolism, tran

71 truction by focusing on discovery of the key regulatory genes at the top of the network.

72 from RPE-specific deletion of the autophagy regulatory gene Atg7 by generating Atg7(flox/flox);VMD2-

73 of Bacillus anthracis, specific towards the regulatory gene atxA.

74 ations primarily in specific transcriptional regulatory genes, augmented by changes in chromatin stru

75 In-frame deletion of two COG3413 family regulatory genes, bat and dmsR, showed downregulation of

76 dentity, JAG directly repressed the meristem regulatory genes BREVIPEDICELLUS and BELL 1 in developin

77 delayed mRNA accumulation of the key asexual regulatory genes brlA, abaA, and vosA.

78 e human T-cells via inhibition of cell cycle regulatory genes but did not induce apoptosis.

79 PRMT5 silences the transcription of regulatory genes by catalyzing symmetric dimethylation o

80 ed with each of these clusters is a putative regulatory gene called cnfR (patB) whose product has a C

81 ding that the chromosomal repositioning of a regulatory gene can determine the cellular phenotype unv

82 is to understand how interacting networks of regulatory genes can direct the often highly complex pat

83 ies have demonstrated that HOXB7 is a master regulatory gene, capable of orchestrating a variety of t

84 ) and the extracellular Toll ligand, spatzle regulatory gene cassette, control expression of the anti

85 3 with H3K9me3 to maintain adipogenic master regulatory genes (Cebpa and Pparg) expressed at low leve

86 Regulatory gene circuit motifs play crucial roles in per

87 Regulatory gene circuits with positive-feedback loops co

88 nched-chain amino acids have identified some regulatory genes controlling seed FAAs, the genetic regu

89 es indicated that a primer pair spanning the regulatory gene cpsB could putatively amplify 84 serotyp

90 ion was higher expression of negative immune regulatory genes (CTLA4, CD69 and PD-L1) in mild lesions

91 ter to express the essential transcriptional regulatory gene ctrA in a periodic, pulsed fashion.

92 hat PUB4 promotes expression of a cell cycle regulatory gene, CYCD6;1, and regulates formative pericl

93 erge diverse circuitries relating downstream regulatory genes directly and indirectly to Nodal signal

94 te transcription of apoptotic and cell cycle regulatory genes downstream of PI 3-kinase/Akt/GSK3 sign

95 new functions, explaining broad retention of regulatory genes during animal evolution.

96 oper mRNA splicing of a set of developmental regulatory genes during early frog development and gastr

97 most sequenced organisms the number of known regulatory genes (e.g., transcription factors (TFs)) vas

98 on patterns for a large number of individual regulatory genes each hour up to gastrulation (30 h) in

99 tool for characterizing the activity of cis-regulatory gene elements during development.

100 reliable way to evaluate the activity of cis-regulatory gene elements in the intact F0 embryo.

101 al transition, the repression of the luminal-regulatory genes Elf5 and Hey1, and claudin down-regulat

102 Here we examine two regulatory genes encoding repressors, sip1 and ets4, whi

103 ere we report that a subset of developmental regulatory genes, enriched in critical RNA-processing fa

104 found rapid and broad upregulation of immune-regulatory genes, essentially triggered by CTL-derived I

105 It is unclear how regulatory genes establish neural circuits that compose

106 Both at the level of structural and regulatory genes, evolution of PA biosynthesis proceeded

107 bryonic stem cells keep active developmental regulatory genes expressed at very low levels and poised

108 LXR, thus leading to suppressed cholesterol regulatory gene expression and providing a biochemical m

109 , greater apoptosis, and attenuated myogenic regulatory gene expression and stress-responsive signali

110 ave identified key differences in cell cycle regulatory gene expression and transit times between nor

111 hybridization to generate a detailed map of regulatory gene expression domains in the embryonic zebr

112 RNs) control the dynamic spatial patterns of regulatory gene expression in development.

113 inflammatory phenotypes and promotes immune regulatory gene expression in the inflamed colonic epith

114 s utility, we use GEM to analyze patterns of regulatory gene expression in the non-skeletogenic mesod

115 osteoblast differentiation and abolished Wnt regulatory gene expression induced by alpha5beta1 integr

116 and malignant cells in which structural and regulatory gene expression is repressed, suggesting a ke

117 A and "degradome" sequencing, we studied the regulatory gene expression network underlying the double

118 petal spurs could have evolved by changes in regulatory gene expression that cause rapid and potentia

119 tal functions of the Wnt-signaling system in regulatory gene expression throughout the embryo were st

120 chnological applications as a cost-effective regulatory gene expression tool.

121 static progression, including alterations in regulatory gene expression, remain undefined.

122 ding precise temporal and spatial control of regulatory gene expression.

123 We show that the pilus regulatory gene fimK promotes the virulence of K. pneumo

124 ns that lack flagella due to deletion of the regulatory gene fleQ.

125 via influencing the expression of flowering regulatory genes FLOWERING LOCUS C and FLOWERING LOCUS T

126 (Lhx8_enh1) located upstream of Lhx8, a key regulatory gene for craniofacial development.

127 was recently identified as a novel negative regulatory gene for the QS system of another rice pathog

128 ichment and the over-representation of eight regulatory genes for endosperm development.

129 multiple shared biological pathways and key regulatory genes for the development of CVD and T2D.

130 ion (RAD50, IL13, and IL4), but not in the T-regulatory genes (FOXP3, RUNX3).

131 he intermediate class was overrepresented in regulatory genes, further suggesting that these represen

132 ereas a mutant with a deletion in the global regulatory gene gacA produces none of these exoproducts

133 the alternative sigma factor rpoS and of the regulatory gene gadE resulted in very high levels of glu

134 lenge to discover the human-specific cardiac regulatory genes, given that most coding genes are conse

135 ents were used to build a network of the key regulatory genes governing mouse stem cell maintenance a

136 ents were used to build a network of the key regulatory genes governing mouse stem cell maintenance a

137 r the past 15 years, mutations in complement regulatory genes have been demonstrated to predispose to

138 ossess homologs of this GTA's structural and regulatory genes have provided important new connections

139 we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin

140 enerate PCR to identify a positive hemolysin regulatory gene, hlyU, from the unsequenced V. anguillar

141 We also identified a unique regulatory gene hom15 at one end of the gene cluster enc

142 In addition, mutation of the regulatory gene hutC resulted in the loss of biofilm, in

143 tral WGDs resulted in the diversification of regulatory genes important to seed and flower developmen

144 These results suggest that hnf4 is a regulatory gene in planarian regeneration, validate the

145 Generation of a knockout mutant of this regulatory gene in the nonfood bacterial strain altered

146 LYWCH1, PSORSIC3, and G3BP1 are novel master regulatory genes in CAD that may be suitable targets.

147 fications modulates the expression of master regulatory genes in development.

148 st observed at promoters of lineage-specific regulatory genes in embryonic stem cells in culture.

149 ATA3 bind to multiple distal sites at immune regulatory genes in human effector T cells.

150 For example, epigenetic modifications of key regulatory genes in hybrids and allopolyploids can alter

151 Previously, to define the role of some regulatory genes in modulating Act production, we showed

152 tform to identify novel BIA biosynthetic and regulatory genes in opium poppy has been established bas

153 ine the landscape of mutations in epigenetic regulatory genes in paediatric cancer and yield a valuab

154 is associated with down-regulation of CCND1 regulatory genes in sporadic parathyroid adenomas.

155 e presence of genomic imprinting in nutrient-regulatory genes in the adult mammary gland.

156 odal target goosecoid, repress expression of regulatory genes in the central animal oral ectoderm the

157 downregulates the expression of several key regulatory genes in the root tip, including SCARECROW, W

158 three of the most commonly mutated chromatin regulatory genes in two Kras(G12D)-driven mouse models o

159 xpression and methylation profiles of stress regulatory genes in various brain areas.

160 temporal expression of cap5 and hla and the regulatory genes in vivo was carried out using a rat inf

161 promoter regions of important hematopoietic regulatory genes including EBF1, GATA1, and TNF.

162 Transcript levels for early hematopoietic regulatory genes including lmo2 and scl are unaltered, b

163 on for mutations found in known and putative regulatory genes, including hns and vieA, diguanylate cy

164 otentially activating integrations in immune regulatory genes, including interleukin-15 (IL-15), IL-6

165 ll under the control of a central cluster of regulatory genes, including nuclear factor kappaB and he

166 ion factor that directly up-regulates sterol regulatory genes, including PCSK9 Given that PCSK9 contr

167 Wee1 inhibition revealed enrichment of G1/S regulatory genes, including SKP2, CUL1, and CDK2.

168 ssociated with upregulation of several actin regulatory genes, including Snai2 and the Rho GTPase pro

169 GOF mutants bind to and upregulate chromatin regulatory genes, including the methyltransferases MLL1

170 ts alternative splicing fates of several key regulatory genes, including those involved in Wnt signal

171 promoter to create mice in which key hypoxia regulatory genes, including VHL, HIF-1alpha, HIF-2alpha,

172 tonomous pathway through the activity of the regulatory gene indeterminate1 (id1), and tropical teosi

173 rthermore, qRT-PCR profiling of key ripening regulatory genes indicates that the SlymiR157-target LeS

174 Perturbations of key regulatory genes induced a jump to a nearby attractor.

175 messenger RNA expression of the cholesterol regulatory gene insulin-induced gene-1 was higher with t

176 es necessitating the inclusion of additional regulatory genes into the core clock network at differen

177 ted protein kinase and downregulation of key regulatory genes involved in both lipid and glucose meta

178 2 uniquely altered expression of an array of regulatory genes involved in cardiomyocyte homeostasis a

179 atory genes and perturbation analyses of key regulatory genes involved in euechinoid oral-aboral patt

180 understanding of not only the structural and regulatory genes involved in metabolite biosynthesis but

181 nts with intragenic breakpoints altering key regulatory genes involved in PDAC progression were detec

182 se genes and analyzed expression profiles of regulatory genes involved in reproductive development.

183 egastrular D/N signaling targets among these regulatory genes is small and is almost exclusively rest

184 The CD40 gene, an important immune regulatory gene, is also expressed and functional on non

185 In addition to alginate biosynthetic and regulatory genes, KinB and RpoN also control a large num

186 t the defect can be overcome by deleting the regulatory gene lcrQ.

187 We find that Ubx targets range from regulatory genes like transcription factors and signalin

188 promoter depended on whether the V. fischeri regulatory gene litR was also introduced.

189 F RNA regulates the expression of the global regulatory gene lrp.

190 nisms are thought to be due to disruption of regulatory genes (lysyl oxidase-like and clusterin) that

191 This unique mechanism, if adopted by other regulatory genes, may provide new biological insights in

192 Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs i

193 Whereas negative regulatory gene MEFV was upregulated, CD40LG and PYDC1 w

194 ssion of either of the two positively acting regulatory genes, mibR or mibX, leads to precocious and

195 the regulation of transcription of key cell regulatory genes [micro RNAs (miRNAs)] during different

196 sis of >500 human cirrhotics revealed global regulatory gene modules driving HCC risk and the lysopho

197 n the phenotypic variability associated with regulatory gene mutations, the rapid examination of thes

198 specific consequences of naturally occurring regulatory gene mutations.

199 is subject, we identified the structural and regulatory genes necessary for the utilization of alpha-

200 evelopment requires the expression of master regulatory genes necessary to specify a cell lineage.

201 This process is tightly controlled by a regulatory gene network centered on the transcriptional

202 We further created an integrated regulatory gene network of the salt response in P. euphr

203 Little is known regarding the regulatory gene networks controlling endosperm prolifera

204 ineage-specific gene families into conserved regulatory gene networks to create functional organ dive

205 ent and differentiation under the control of regulatory gene networks, which include the distal-less

206 Analysis of the key regulatory gene, Npas4, indicated that its promoter regi

207 own defence genes, such as the master immune regulatory gene NPR1 (ref.

208 SHORT HYPOCOTYL UNDER BLUE1 (SHB1) is a key regulatory gene of seed development with a broad express

209 has recently been identified as a novel key regulatory gene of the DNA damage response pathway.

210 The glial cells missing (gcm) regulatory gene of the sea urchin Strongylocentrotus pur

211 hering various structural, rate limiting and regulatory genes of CPT biosynthetic pathway.

212 r with the down-regulation of structural and regulatory genes of the flavonoid pathway as revealed by

213 owledge of the epistatic relations among the regulatory genes of the oral ectoderm.

214 dent growth control in vivo and conserves QS regulatory genes, of which one can complement a T. bruce

215 The effect of deletions of the regulatory genes on the GDAR system and the effects of o

216 transcriptional repressors, the products of regulatory genes operating across the border of each sub

217 lization of the exsB gene within the exsCEBA regulatory gene operon suggested an implication in the T

218 ization of the ExsB-encoding gene within the regulatory gene operon.

219 diseases are characterized by the failure of regulatory genes or proteins to effectively orchestrate

220 The regulatory gene PAP1 (production of anthocyanin pigment

221 RPE experimentally manipulated to express a regulatory gene participating in transcriptional network

222 In addition, GCNF also showed a regulatory gene pattern that is different from RA treatm

223 ngle AAV vector and targeted the cholesterol regulatory gene Pcsk9 in the mouse liver.

224 was a concomitant decrease in mitochondrial regulatory genes PGC-1alpha, SLC25A25, NRF1, and TFAM, s

225 starvation and limitation although a second regulatory gene, phoB, was not.

226 ated with upregulated expression of negative regulatory genes PIAS3, SHP2, and SOCS3 in CD4 T cells.

227 xpression of genes, including the transposon regulatory gene piwi, in terminally differentiated cells

228 key transcription factors and other crucial regulatory genes play in these events.

229 Mutations in bacterial regulatory genes played no detectable role in this outbr

230 re tool, we characterized as hnf4 an unknown regulatory gene predicted to exist by the reverse-engine

231 A P-stress regulatory gene, ptrA, was upregulated in response to bo

232 t DLDH did not regulate rafK or the putative regulatory genes rafR and rafS.

233 r function and distribution around important regulatory genes raises the question of how they relate

234 Not only are different regulatory genes rapidly regulated by light in each orga

235 post-translational and post-transcriptional regulatory genes rather than in genes directly involved

236 Expression of apoptotic regulatory genes regulated by E2f, like Apaf1 and Bak1,

237 ransport is still fragmentary, and important regulatory genes remain to be identified.

238 With this method, which involves regulatory gene remodeling, we successfully expressed a

239 Master regulatory genes require stable silencing by the polycom

240 represses transcription of ssrB, a virulence regulatory gene required for expression of the Spi/Ssa t

241 ession, as well as altered expression of MYC regulatory genes, resulting in increased activity of the

242 consisting of contiguous enzymatic and often regulatory gene(s) devoted to the production of a metabo

243 edicts genetic linkage of a gamete cell-size regulatory gene(s) to an ancestral mating-type locus as

244 uired for tissue growth, and it shows that a regulatory gene shapes plant organs by releasing a const

245 algorithm retained all triple genes where a regulatory gene significantly interfered two paired path

246 c state through the suppression of chromatin regulatory genes Sin3b, Hbp1, Suv420h1, and Btg1, as wel

247 There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) i

248 sites adjacent to a number of heterochronic regulatory genes, some of which drive male-specific expr

249 Remarkably, almost all of the regulatory genes specifically expressed within these dom

250 overexpression of BTB (blood-testis barrier) regulatory genes such as FAK and its phosphomimetic muta

251 these mutants reveals that mutations in key regulatory genes such as HXK2 and STD1 adjust the regula

252 5+FoxP3+ cells exhibit reduced expression of regulatory genes such as IL-10, and adoptive transfer of

253 including ubiquitously expressed cell cycle regulatory genes, such as CCNB1 and CCNB2, CDK1, and TOP

254 Key regulatory genes, suppressed by Polycomb and H3K27me3, b

255 S and dCAPS markers for cotton developmental-regulatory genes that are important in plant breeding pr

256 Here we describe additional regulatory genes that contribute to the oral ectoderm re

257 In a screen for dauer regulatory genes that control the activity of the FoxO t

258 We next identified mutations in regulatory genes that disrupted the wild-type pattern of

259 Signal reception leads to expression of regulatory genes that later contribute to the aboral NSM

260 uding rare intermediates and the networks of regulatory genes that orchestrate cell-type specificatio

261 n-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various pro

262 st time, we were able to show a hierarchy of regulatory genes that regulated downstream biosynthetic

263 rs act during cortical development as master regulatory genes that specify cortical arealization and

264 MicroRNAs (miRNA) are regulatory genes that target and repress other RNA molec

265 rt increased expression of E2f and apoptotic regulatory genes that trigger apoptosis upon Rb1 loss.

266 The regulatory genes that underlie the formation of these mu

267 omains generally marked by the expression of regulatory genes, the embryonic brain of the lamprey, a

268 rticipant in the epigenetic silencing of HSC regulatory genes, thereby enabling efficient differentia

269 tains most of the structural, enzymatic, and regulatory genes thought to be involved in PDU microcomp

270 Kdm5a is a direct repressor of metabolic regulatory genes, thus explaining the compensatory role

271 athogen-induced ectopic co-expression of two regulatory genes to enhance pathogen success, although t

272 probe the mechanisms that predispose ancient regulatory genes to reutilization and diversification ra

273 nd the resulting inappropriate expression of regulatory genes, together, lead to oncogenesis.

274 cific deletion of Bax, but not the apoptosis regulatory gene Tp53 (encoding p53), significantly reduc

275 ired for conjugative transfer, including the regulatory genes traR, traI, and traM.

276 8/Fog) that is deployed by the developmental regulatory genes twist and snail [7-10].

277 nd are wired in tandem, plus a set of target regulatory genes under hesC control.

278 ression of algR, an alginate transcriptional regulatory gene, under ciprofloxacin pressure.

279 In Aspergillus nidulans the global regulatory gene veA is necessary for the biosynthesis of

280 About 7-fold upregulation of the biofilm regulatory gene vpsT was observed within 30 minutes of a

281 The transcription of a few regulatory genes was also affected, and the role of one

282 Whereas expression of iron-regulatory genes was markedly down-regulated, genes rela

283 In addition, the expression of cell cycle regulatory genes was measured by qRT-PCR and immunoblott

284 The level of expression of these cell-cycle regulatory genes was relevant to human tumors with low D

285 ammation was caused by mutation in the actin regulatory gene WDR1 We report a homozygous missense mut

286 These changes in stress regulatory genes were normalized following treatment wit

287 Numerous iron regulatory genes were significantly changed in the light

288 luding all spatially expressed oral ectoderm regulatory genes, were established.

289 The identification of a stem cell regulatory gene which is aberrantly expressed in glioma

290 NAs (miRNAs) are a newly recognized class of regulatory genes which repress the expression of protein

291 cognition receptor that triggered downstream regulatory genes, which in turn, regulated downstream me

292 4me3 modification, and they include numerous regulatory genes, which may act as primary response gene

293 oughout development and identifies candidate regulatory genes, which warrant further investigation in

294 upregulated expression of a panel of immune-regulatory genes, which was distinctly different from th

295 are coregulated by the supercluster-embedded regulatory gene with biosynthetic genes belonging to one

296 The regulatory genes with highest interference frequency wer

297 We suggest that certain regulatory genes with low pleiotropy are predisposed to

298 monstrated that PML shared a large cohort of regulatory genes with Stat1 and Stat3, indicating an imp

299 Nodal signaling drives cohorts of regulatory genes within the oral ectoderm and its derive

300 toward upregulation of immune activation and regulatory genes, without signs of rejection.