ライフサイエンスコーパス: regulatory subunit

1 isting of Nem1 (catalytic subunit) and Spo7 (regulatory subunit).

2 complexes targeted to c-Jun by the PR55alpha regulatory subunit.

3 regulated by the phosphorylation of its B'' regulatory subunit.

4 nt on phosphorylation of Ser108 in the beta1 regulatory subunit.

5 targeting of the holoenzyme via the CK2beta regulatory subunit.

6 (PP1) subunit in complex with a PPP1R15-type regulatory subunit.

7 t chain or of myosin light chain phosphatase regulatory subunit.

8 es, a MAPK, a cyclophilin, and a calcineurin regulatory subunit.

9 K2) substrate recruitment site on the cyclin regulatory subunit.

10 of a core dimer (AC) bound to a variable (B) regulatory subunit.

11 affold and catalytic subunits and a variable regulatory subunit.

12 egulatory Associated Protein of TOR (RAPTOR) regulatory subunit.

13 catalytic subunit, a scaffold subunit, and a regulatory subunit.

14 ing through increased phosphorylation of PKA regulatory subunits.

15 eries of specific activators, inhibitors and regulatory subunits.

16 hanism(s) that function independently of the regulatory subunits.

17 s B'beta, thus promoting exchange with other regulatory subunits.

18 addition to creating rings, kleisins recruit regulatory subunits.

19 aling pathways when associated with specific regulatory subunits.

20 that is decorated with a variable number of regulatory subunits.

21 eraction is specific to the B' family of the regulatory subunits.

22 ptor (IGF1R), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1, or p85a) and funct

23 the adaptor protein cyclin-dependent kinase regulatory subunit 1 (Cks1), a cofactor of the SCF(Skp2)

24 M188, renamed nuclear envelope phosphatase 1-regulatory subunit 1 (NEP1-R1).

25 mphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog

26 or 1b (cdkn1b) and phosphoinositide-3-kinase regulatory subunit 1 (pik3r1).

27 erentially regulated by LCMT-1, with the PP4 regulatory subunit 1 (PP4R1)-containing PP4 complex bein

28 we show that the 26 S proteasome non-ATPase regulatory subunit 13 (PSMD13), a newly identified negat

29 The 26S proteasome non-ATPase regulatory subunit 13 mediated degradation specifically

30 ease 14 (USP14) is a component of proteasome regulatory subunit 19 S that regulates deubiquitinated p

31 generated larvae carrying a mutation in cdk5 regulatory subunit 1a (cdk5r1a), an essential activator

32 Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phos

33 Protein phosphatase 1 regulatory subunit 1B(+) BLA pyramidal neurons to dopami

34 ith decreased expression of protein kinase A regulatory subunit 1beta (PRKAR1beta), activation of pro

35 We now find that the EVH1 domain of the regulatory subunit 3 of Drosophila PP4, Falafel (Flfl),

36 Moreover, we identified PP1 regulatory subunit 3B (PPP1R3B) as a targeting subunit t

37 ry protein (GCKR), and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) that were strongly assoc

38 ant near the gene for protein phosphatase 1, regulatory subunit 3B (PPP1R3B; rs4841132, beta = -0.116

39 apped region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a protein (GL) that regu

40 spn; gene name Ppp1r9b protein phosphatase 1 regulatory subunit 9b) and the clathrin adaptors AP-1 an

41 f a catalytic, a scaffolding, and a variable regulatory subunit, all encoded by multiple genes, allow

42 Mechanistically, TAp73 interacts with the regulatory subunit (alpha) of HIF-1 and recruits mouse d

43 Only the B55alpha (55-kDa regulatory subunit, alpha isoform) regulatory subunit of

44 Global heterozygous deletion of the Pik3r1 regulatory subunits (alphaHZ), but not knockout of Pik3r

45 AMPK through interactions with the AMPK beta regulatory subunit and phosphorylates the AMPK alpha cat

46 mouse embryos have reduced levels of PP2A B regulatory subunit and PP4R1 relative to control MEFs, i

47 ed cAMP binding to two tandem domains of the regulatory subunit and release of the catalytic subunit.

48 until the kinase domain associates with its regulatory subunits and overcomes the energetic barrier

49 es not interact with the beta and Snf4/gamma regulatory subunits, and its activity was independent of

50 catalytic and one of any of four families of regulatory subunits, and the interaction is specific to

51 nic kidney cells and rat organs reveals that regulatory subunits are always in large molar excess of

52 ese processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.

53 catalytic gamma- and epsilon-subunits, with regulatory subunits arranged in asymmetric trimers assoc

54 e-binding domain of protein kinase A's (PKA) regulatory subunit as a prototype signalling unit, we co

55 llular localization (dictated by select PP2A regulatory subunits) as well as local specific post-tran

56 As p85 regulatory subunits associate with and inhibit all class

57 tes interfaces for efficient binding to CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) and c

58 r mutations in protein phosphatase 2A (PP2A) regulatory subunit B family genes protein phosphatase 2,

59 ify Drosophila protein phosphatase 2A (PP2A) regulatory subunit B' [Wrd (Well Rounded)] as a Liprin-a

60 ubunit B family genes protein phosphatase 2, regulatory Subunit B', beta (PPP2R5B); protein phosphata

61 gamma (PPP2R5C); and protein phosphatase 2, regulatory Subunit B', delta (PPP2R5D).

62 t B', beta (PPP2R5B); protein phosphatase 2, regulatory Subunit B', gamma (PPP2R5C); and protein phos

63 (A), a catalytic subunit (C), and a variable regulatory subunit (B).

64 hat the Dictyostelium protein phosphatase 2A regulatory subunit B56, encoded by psrA, modulates Dicty

65 rine/threonine protein phosphatase 2A (PP2A) regulatory subunit, B56beta, due to increased steady-sta

66 luciferase reporter, we identified the PP2A regulatory subunit B56gamma as negative regulator of NF-

67 atase PP2A, in conjunction with its B55alpha regulatory subunit, becomes limiting for replication ori

68 posed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma), which act as a met

69 trimer composed of a catalytic alpha and two regulatory subunits (beta and gamma).

70 r, we find that the L205R mutation abolishes regulatory-subunit binding, leading to constitutive, cAM

71 g shut a "DNA exit gate." How Scc3 and Pds5, regulatory subunits bound to alpha-kleisin, regulate coh

72 profile with enhanced binding to the alpha4 regulatory subunit, but no binding to the scaffolding su

73 channel pore-forming subunit, alpha1, and a regulatory subunit (Ca(V)beta) form a high affinity comp

74 Interaction of MAT2A with its MAT2B regulatory subunit causes no change in the intrinsic KIE

75 rometry shows that association with the p101 regulatory subunit causes substantial protection of the

76 budding yeast, the holoenzyme comprises two regulatory subunits, Ckb1 and Ckb2, and two catalytic su

77 ruitment of Cdk-cyclin in complex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop o

78 the catalytic subunit is promiscuous and the regulatory subunit confers substrate specificity.

79 n FL-HCC, the DnaJ-PKA chimera remains under regulatory subunit control; however, its overexpression

80 mains by CDK1 in complex with p9/Cks2 (a CDK regulatory subunit) controlled loading of coactivator Cd

81 cific DNA-binding protein Cep3 together with regulatory subunits Ctf13 and Skp1.

82 erodimer composed of the Cdc7 kinase and its regulatory subunit Dbf4.

83 lly during late G1/S phase by binding to its regulatory subunit, Dbf4.

84 isrupt AKAP interaction with the PKA RIIbeta regulatory subunit, decreased inhibition of cAMP product

85 at PKA catalytic subunits remain tethered to regulatory subunits during cAMP elevation.

86 nsists of the catalytic Est2 protein and two regulatory subunits (Est1 and Est3) in association with

87 Subunit 4 (COX4), a key regulatory subunit, exists as two isoforms, the ubiquito

88 arepsilon with Frizzled-bound PR61varepsilon regulatory subunit, facilitating the access of PP2A cata

89 a catalytic subunit, factor Xa (fXa), and a regulatory subunit, factor Va (fVa), assembled on a memb

90 dification, and/or trafficking in any of the regulatory subunits forming cardiac L-type Ca(2+) channe

91 In mammalian cells, the regulatory subunits GADD34 and CReP target PP1 to dephos

92 a hypomorphic allele of the RPT2 proteasome regulatory subunit gene (rpt2(E301K)) suppressed the ubi

93 Upon the addition of glucose the regulatory subunit Gid4/Vid24 appears, binds to the Gid

94 affold dimer and either the B55alpha or PR70 regulatory subunit have been implicated in the activatio

95 PKA holoenzyme is a tetramer (R2:C2), with a regulatory subunit homodimer (R2) that binds and inhibit

96 talytic (C) subunits; binding of cAMP to the regulatory subunit homodimer causes activation of the ca

97 In WT S49 cells, PKA-regulatory subunit I (RI) and Bim coimmunoprecipitate up

98 Here, we find that the Pik3r1 regulatory subunits (i.e., p85alpha/p55alpha/p50alpha) a

99 Furthermore, the PKA regulatory subunit II exists mainly in the less cAMP-res

100 ed content of the juxtanuclearly located PKA regulatory subunit IIalpha and PKA regulatory subunit II

101 LRRK2 interacted with PKA regulatory subunit IIbeta (PKARIIbeta).

102 cated PKA regulatory subunit IIalpha and PKA regulatory subunit IIbeta, and a compensatory increase o

103 insically disordered regions within each PKA regulatory subunit impart the molecular plasticity that

104 hus, haploinsufficiency for either of PKA-II regulatory subunits improved bone phenotype of mice hapl

105 ignaling, we solved the structure of the PKA regulatory subunit in complex with cAMP and a related an

106 ten unpredicted roles for PI3K catalytic and regulatory subunits in normal cell function and in disea

107 (cAMP-dependent protein kinase type I-alpha regulatory subunit) in 58 SCD patients (P = 7.9 x 10 - 7

108 he expression of PR55alpha (PPP2R2A), a PP2A regulatory subunit, in pancreatic cancer cells compared

109 a, which encodes for the critical type-I PKA regulatory subunit, induced spontaneous breast tumors ch

110 of the core catalytic subunit PP-1c and the regulatory subunit inhibitor 2 (I-2).

111 m-localized protein phosphatase 2A (PP2A) B' regulatory subunits interact with BRI1 to mediate its de

112 -structures, in concert with the static AKAP-regulatory subunit interface, generates a solid-state si

113 n malignant breast cancer cells, the CK2beta regulatory subunit is downregulated and FOXC2 is found i

114 at the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human and mouse pancr

115 by deleting Reg1, a Glc7 protein phosphatase regulatory subunit, is lethal in combination with defect

116 their activation depends on association with regulatory subunits known as cyclins.

117 constraint, independent of either DNA or its regulatory subunit Ku.

118 nits, Lac1 and Lag1, as well as an essential regulatory subunit, Lip1.

119 cation of B56delta, which we identify as the regulatory subunit mediating PP2A-dependent Bcl-2 dephos

120 osphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin phosphatase targeting subunit

121 lation of the myosin light chain phosphatase regulatory subunit MYPT1 at Thr-696 and Thr-853 and the

122 t chain phosphatase (MLCP), which contains a regulatory subunit MYPT1 bound to the phosphatase cataly

123 estigated the physiological role of the MLCP regulatory subunit MYPT1 in bladder smooth muscle contai

124 estigated the physiological role of the MLCP regulatory subunit MYPT1 in ileal smooth muscle in adult

125 it (MYPT) family member, in addition to MLCP regulatory subunit MYPT1.

126 MLCP with its regulatory subunit MYPT2 bound tightly to myofilaments w

127 , USP18 targeted the IKK complex through the regulatory subunit NEMO of IKK, and specifically inhibit

128 bunits, IKKalpha and IKKbeta, as well as the regulatory subunit, NEMO-mediates activation of the nucl

129 al structures and biophysical studies of the regulatory subunit, NeqB, the apo-NeqAB, and NeqAB in co

130 ASXL1 is the obligate regulatory subunit of a deubiquitinase complex whose cat

131 The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates t

132 Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates t

133 Here we show that PPFR-1, a regulatory subunit of a trimeric protein phosphatase 4 c

134 k2 as query mutants, the latter encoding the regulatory subunit of AMPK.

135 F2alpha phosphorylation [CReP]) encoding the regulatory subunit of an eIF2alpha-specific phosphatase

136 e sulfonylurea receptor 2B (SUR2B) forms the regulatory subunit of ATP-sensitive potassium (KATP) cha

137 processes, we mutagenized Mcd1p, the kleisin regulatory subunit of budding yeast cohesin.

138 Myristoylation of the regulatory subunit of calcineurin (CNB) is conserved fro

139 The M-domain is the major regulatory subunit of cardiac myosin-binding protein-C (

140 The truncated regulatory subunit of CDK5, P25, accumulated in senescen

141 n yeast, we evaluated the role of CDC55, the regulatory subunit of ceramide-activated protein phospha

142 ations in PIK3R1, which encodes the p85alpha regulatory subunit of class IA PI3Ks, lead to immunodefi

143 and chronic depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin

144 Mice lacking the RIIbeta regulatory subunit of cyclic AMP-dependent protein kinas

145 Upon exit from prophase I, Dbf4, the regulatory subunit of DDK, directly associates with and

146 show here that the mRNA of CReP/Ppp1r15b, a regulatory subunit of eukaryotic translation initiation

147 ssion of the cystine transporter xCT and the regulatory subunit of glutamate-cysteine ligase (GCLM) i

148 pregulated HIF-1 activity by stabilizing the regulatory subunit of HIF-1 (HIF-1alpha) in a murine bre

149 a inducible factor 1 alpha (HIF-1alpha), the regulatory subunit of HIF-1, a master transcriptional re

150 u-mediated ubiquitination of HIF-1alpha, the regulatory subunit of HIF-1, and consequently promotes m

151 of residues of the catalytic domain and the regulatory subunit of human PI3Kalpha in lipid and prote

152 Vice versa, in cardiomyocytes lacking the regulatory subunit of IKK (IKKgamma/NEMO), the induction

153 ntrolled by IKKgamma (also called NEMO), the regulatory subunit of IKK complex.

154 nation of IkappaB kinase gamma (IKKgamma), a regulatory subunit of IKK, is instrumental in the activa

155 ha and IKKbeta, as well as the IKKgamma/NEMO regulatory subunit of IKK.

156 eration and found that a mutation in the p80 regulatory subunit of katanin, encoded by the PF15 gene

157 tivates Rho kinase, which phosphorylates the regulatory subunit of MLC phosphatase, thereby inhibitin

158 sphorylation status of endogenous MYPT1 (the regulatory subunit of myosin light chain phosphatase) at

159 myosin phosphatase-targeting subunit 1, the regulatory subunit of myosin phosphatase that is inhibit

160 hat global knock-out of a small, single-span regulatory subunit of Na,K-ATPase, FXYD2, alters glucose

161 The p47(phox) is a key regulatory subunit of NADPH oxidase; however, due to the

162 The canonical action of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase (PI3

163 Mutation or loss of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3

164 osis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase (PI3

165 cells: phosphotyrosine (pY) peptide IP, p85 regulatory subunit of phosphoinositide-3-kinase (PI3K) I

166 heterozygous mutations in PIK3R1 encoding a regulatory subunit of phosphoinositide-3-kinase (PI3K).

167 raction with Crk family proteins and the p85 regulatory subunit of PI3-Kinase, respectively.

168 sphatase type II (SHP2) to the Pi3k21B (p60) regulatory subunit of PI3K (p50/p85 human ortholog) but

169 mutations in the gene encoding the p85alpha regulatory subunit of PI3K (PIK3R1) have been identified

170 Mechanistically, 14-3-3zeta bound to the p85 regulatory subunit of PI3K and increased PI3K translocat

171 Here we demonstrate that the p85 regulatory subunit of PI3K is an IKK substrate, phosphor

172 89), a canonical binding site for the 85-kDa regulatory subunit of PI3K that allosterically activates

173 We identified a role for the p85alpha regulatory subunit of PI3K to modulate the UPR by promot

174 PIK3R1 (p85alpha regulatory subunit of PI3K) is frequently mutated across

175 K3R1, the gene that encodes for the p85alpha regulatory subunit of PI3K, have been recently identifie

176 nsense mutation in PIK3R1, which encodes the regulatory subunit of PI3K, in a metastatic RCC (mRCC),

177 ing catalytic p110alpha subunit and p85alpha regulatory subunit of PI3K, leading to activation of AKT

178 It also interfered with activation of the regulatory subunit of PI3K, p85, and activation of Akt i

179 tion promoting genes, uniquely uses p55gamma regulatory subunit of PI3K, rather than more common p85

180 uces Cbl-dependent ubiquitination of the p85 regulatory subunit of PI3K, which binds to phosphotyrosi

181 -cyclic phosphodiesterase 4D (PDE4D) and the regulatory subunit of PKA (PRKAR1alpha) content culminat

182 MP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity o

183 y high-affinity association of cAMP with the regulatory subunit of PKA and signal termination is achi

184 nase anchoring protein that binds the type I regulatory subunit of PKA, and it is phosphorylated by P

185 ss of Prkar1a, the gene encoding the type 1A regulatory subunit of PKA, in SC to study its role in ne

186 Leu206 directly interacts with the regulatory subunit of PKA, PRKAR1A.

187 chieved through direct interactions with the regulatory subunit of PKA, thereby facilitating cAMP dis

188 e length: Prkar1a, which encodes the R1alpha regulatory subunit of PKA.

189 t miR-297c-5p targets cyclin T2 (CCNT2), the regulatory subunit of positive transcription elongation

190 Multisite phosphorylation of the I-2 regulatory subunit of PP-1I leads to activation or inact

191 erexpression of SIPP1, a cytoplasm-shuttling regulatory subunit of PP1, and increased EBOV transcript

192 a (55-kDa regulatory subunit, alpha isoform) regulatory subunit of PP2A was able to bind p107, and th

193 CKA is a regulatory subunit of PP2A, a component of the STRIPAK c

194 opening, and resulted in the truncation of a regulatory subunit of PP2A, B56alpha.

195 nt for its dissociation from the type Ialpha regulatory subunit of protein kinase A (PKA) in the cyto

196 PRKAR1A deficiency; PRKAR1A codes for type-I regulatory subunit of protein kinase A (PKA).

197 ng of two protein-ligand systems: cAMP-bound regulatory subunit of Protein Kinase A (RIalpha) and IBM

198 in PRKAR1A, which encodes the cAMP-dependent regulatory subunit of protein kinase A and which has bee

199 plex gene Prkar1a, which encodes the type 1A regulatory subunit of protein kinase A.

200 f eIF2alpha by increased levels of GADD34, a regulatory subunit of protein phosphatase 1 (PP1).

201 cule that safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

202 kdown of PPP2R1A, a gene encoding a constant regulatory subunit of protein phosphatase 2, significant

203 genesis checkpoint also depended on Cdc55, a regulatory subunit of protein phosphatase 2A (PP2A).

204 Gankyrin is a regulatory subunit of the 26kD proteasome complex.

205 Cyclin E1 (CcnE1) is the regulatory subunit of the cyclin-dependent kinase 2 (Cdk

206 ved eukaryotic protein that functions as the regulatory subunit of the Dbf4-dependent kinase (DDK) co

207 ctor kinase Rad53 and the BRCT domain of the regulatory subunit of the Dbf4-dependent kinase that is

208 characterized the function of BAF250a, a key regulatory subunit of the ES cell ATP-dependent Brahma-a

209 Here we show that Rts1, a regulatory subunit of the general protein phosphatase 2A

210 B (NF-kappaB) essential modulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

211 eleterious mutations in KATNB1, encoding the regulatory subunit of the microtubule-severing enzyme Ka

212 consistently elevated expression of MICU2, a regulatory subunit of the mitochondrial calcium uniporte

213 o identify how the genetic deletion of a key regulatory subunit of the mitochondrial permeability tra

214 surface expression of p47(phox), a cytosolic regulatory subunit of the NADPH oxidase NOX2.

215 KBTBD2 targeted p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K

216 Jak3 interacted with and activated p85, the regulatory subunit of the PI3K, through tyrosine phospho

217 dentified a mosaic mutation (Gly373Arg) in a regulatory subunit of the PI3K-AKT-mTOR pathway, PIK3R2,

218 of an activated Smad3-Smad4 complex and the regulatory subunit of the PKA holoenzyme (PKA-R).

219 One of the target genes was Ppp2r2d, a regulatory subunit of the PP2A phosphatase family.

220 The latter is directed by the Ppp2r2a regulatory subunit of the Pp2a phosphatase.

221 T cells promoted interaction of the p85alpha regulatory subunit of the signaling kinase PI(3)K and in

222 emodeling complex identified that BAF250a, a regulatory subunit of the SWI/SNF, plays a key role in C

223 t that conditional knockout of Cdh1, the key regulatory subunit of the ubiquitin ligase Cdh1-anaphase

224 The regulatory subunit of this complex, NF-kappaB essential

225 The main target of cAMP is PKA, the main regulatory subunit of which (PRKAR1A) presents mutations

226 The cyclin D1 gene encodes the regulatory subunits of a holoenzyme that phosphorylates

227 Importantly, the beta and gamma regulatory subunits of AMPK are not required to control

228 By systematically testing the regulatory subunits of Drosophila PP2A, we find that the

229 Cyclins encode regulatory subunits of holoenzymes that phosphorylate a

230 binding proteins NEMO and TAB2 which are the regulatory subunits of IKK and TAK1 kinase complexes, re

231 on channels, to have both functions or to be regulatory subunits of other channels.

232 Thus, regulatory subunits of phosphatases are drug targets, a

233 rmal expression of the p50alpha and p55alpha regulatory subunits of PI3K.

234 SL and Plin1 and the levels of catalytic and regulatory subunits of PKA were increased by glucocortic

235 MEI-S332 can bind directly to both of the B' regulatory subunits of PP2A, Wdb and Wrd, in yeast two-h

236 minal domain recruits both the catalytic and regulatory subunits of the Ca(2+)-activated protein phos

237 radation of all members of the B56 family of regulatory subunits of the key cellular phosphatase PP2A

238 We propose that MrpL35 and Mrp7 are regulatory subunits of the mitoribosome acting to coordi

239 both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is co

240 ure motif F-X-Y-D and act as tissue-specific regulatory subunits of the Na,K-ATPase.

241 recruitment of PP1 (the Dis2 isoform) to the regulatory subunits of the PP2A-B55 and PP2A-B56 (B55 al

242 role of the phosphoinositide 3-kinase (PI3K) regulatory subunits on AT macrophage (ATM) infiltration

243 Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant acti

244 f Gab2, the phosphatidylinositol 3-OH kinase regulatory subunit p85, and Akt, without affecting the L

245 plex with the NGF receptor TrkA and the PI3K regulatory subunit p85, with the degree of TrkA:p85 asso

246 at inhibitory contact sites formed with the regulatory subunit p85alpha.

247 Although the PI3-kinase regulatory subunits p85alpha and p85beta are dispensable

248 Expression of the regulatory subunit p85beta of PI3K induces oncogenic tra

249 PIK3R2 encodes a ubiquitous regulatory subunit (p85beta) of PI3K, an enzyme that gen

250 Interestingly, PfCDPK1 phosphorylates PfPKA regulatory subunit (PfPKA-R) and regulates PfPKA activit

251 etic ablation of the insulin receptor or the regulatory subunits phosphatidylinositol 3-kinase (PI3K)

252 ytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR).

253 cAMP binding to the regulatory subunits (PKAR) relieves their inhibition of

254 accompanied by a decrease in the type I PKA regulatory subunit (PKARIalpha) and activation of RSK1.

255 co-immunoprecipitation of SERCA2, cav3, PKA regulatory subunit (PKARII), PP2A, and AKAP18 with PDE3A

256 of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12.

257 PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is embedded in a feedbac

258 PP2A associated with the Rts1 regulatory subunit (PP2A(Rts1)) is required for cell siz

259 s and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP.

260 ), including the catalytic subunit PPP6C and regulatory subunits PPP6R1 and PPP6R3.

261 loinsufficiency of the protein kinase's main regulatory subunit, PRKAR1A.

262 receptor for protein kinase 1 (RACK1) as the regulatory subunit, protein phosphatase 2A (PP2A) dephos

263 Here, we show that a dynamic linker in the regulatory subunit (R) of PKA serves not only as a passi

264 the central receptor for cAMP is the single regulatory subunit (R) of protein kinase A (PKA).

265 KAR1A tumor suppressor gene that encodes the regulatory subunit R1alpha of the cAMP-dependent protein

266 we found that inhibiting mTOR, depleting its regulatory subunit raptor, or inducing hypoxia all trigg

267 lytic Snf1/alpha subunit, and the Snf4/gamma regulatory subunit regulates phosphorylation through ade

268 NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently o

269 n experiments showed that a group of PP2A B' regulatory subunits, represented by B'eta, negatively re

270 ing CSR and that knockdown of cohesin or its regulatory subunits results in impaired CSR and increase

271 selective high-affinity AKAP for type I PKA regulatory subunits (RI).

272 cleotide phosphodiesterase (PDE8A) and a PKA regulatory subunit (RIalpha isoform) in mammalian cAMP s

273 xpression of the type 3b bipolar cell marker regulatory subunit RII-beta of protein kinase A was unch

274 easome, which is critically dependent on the regulatory subunit Rpn6.

275 volved catalytic (Pph3), scaffold (Psy2) and regulatory subunits (Rrd1, Tip41), as well as uninvolved

276 from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiolo

277 DNA.PK complexes with the regulatory subunit SAPSR1 (R1) of protein phosphatase-6

278 instead, depends on PP1 phosphatase and its regulatory subunit Sds22.

279 y the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic su

280 trols mitosis is associated with a conserved regulatory subunit that is called B55 in vertebrates and

281 inhibitory domain of WNK1 (WNK1-AI), a small regulatory subunit that lies immediately C-terminal of t

282 B'beta is a brain-specific PP2A regulatory subunit that mediates dephosphorylation of Ca

283 in diabetes (downregulation of an inhibitory regulatory subunit) that leads to deficits of circulatin

284 to the paradigm of distinct PP1-targeting or regulatory subunits, the unique N terminus of yeast eIF2

285 o associate with IRS1 independent of the p85 regulatory subunit, thereby rewiring this oncogenic sign

286 , during which the two cAMPs unbind from the regulatory subunit to allow association of the catalytic

287 irect binding of the EVH1 domain of the Psy2 regulatory subunit to the polyproline motif of Mth1.

288 nit, allowing TIPRL, but not the overlapping regulatory subunits, to tolerate disease-associated PP2A

289 rising a lipid kinase, PI4KIIIalpha, and two regulatory subunits, TTC7 and FAM126.

290 used by PRKAR1A mutations, the gene encoding regulatory subunit type 1 of protein kinase A.

291 daptive PP2A complex containing the B55alpha regulatory subunit via providing the catalytic subunit u

292 hromosome arms in a process dependent on the regulatory subunit Wapl.

293 ast mutant restricted in the 19 S proteasome regulatory subunit was unaffected in clearance, whereas

294 the hypothesis that the PRKAR2A and PRKAR2B regulatory subunits were in part responsible for the bon

295 Phylogenetic analysis indicates that regulatory subunits were present in ancestral cnidarians

296 oth PKA catalytic subunit mutants by the PKA regulatory subunit, whereas cells from patients with ger

297 P2R1A increased its binding ability with B56 regulatory subunits, whereas PPP2R1A-mutations lost the

298 Deletion of the BK-beta4 regulatory subunit, which is required for normal BK(Ca)

299 y rescued after concomitant depletion of B55 regulatory subunits, which are mostly cytoplasmic before

300 acidic loop of the PPP2R5D-encoded B56delta regulatory subunit, with the same E198K mutation present