ライフサイエンスコーパス: repressive

1 5 knockdown using siRNA restored fluticasone repressive action on chemokine production and its abilit

2 Remarkably, this dominant repressive activity is dosage-dependent and causes stron

3 SERK3 and SERK1 as well as the promoting or repressive activity of a single coreceptor in multiple s

4 ction synergistically to achieve the overall repressive activity of bile.

5 Our results suggest that the repressive activity of RXR on prometastatic genes is med

6 sites on the scaffold protein Clr1 and that repressive activity of SHREC can be modulated by the exp

7 omoting the localization and transcriptional repressive activity of TRIM28, which binds BORG and indu

8 Individual bile acids exhibit repressive activity on SPI-1-regulated genes that requir

9 ilencing in adults, and that LRF confers its repressive activity through a NuRD repressor complex ind

10 The Snail-repressive activity, here monitored on genes with a pivo

11 Contrary to its canonical repressive activity, PUM1/2 rather promote FOXP1 express

12 re functional and show similar transcription repressive activity.

13 within this enhancer are necessary for this repressive activity.

14 ivalent histone modifications are defined as repressive and activating epigenetic marks that simultan

15 tively bivalent nucleosomes with concomitant repressive and activating marks, as well as other combin

16 o be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GL

17 In contrast to the repressive association of DNA methylation at CG dinucleo

18 ity contribute to HIV-1 latency, and certain repressive cellular factors modulate viral transcription

19 This includes distal enhancers, repressive chromatin and transcriptional units marked by

20 at this assembly is required for maintaining repressive chromatin at the hTERT promoter.

21 re highly enriched for H3K27me3, which forms repressive chromatin domains upon STRAP silencing.

22 se transgenes for germline expression within repressive chromatin domains.

23 and DNA methylation machinery to establish a repressive chromatin environment at a subset of origins,

24 general role in restricting the spreading of repressive chromatin in interphase mammalian cells.

25 A new study shows that repressive chromatin in oocytes can also confer imprinti

26 re known to travel with RNAPII and establish repressive chromatin in order to limit aberrant transcri

27 Subsequently, the repressive chromatin is rapidly dismantled through a mec

28 was accompanied by a reconfiguration of the repressive chromatin landscape: while H3K9me3 was stable

29 of HIF-1alpha are directly controlled by the repressive chromatin mark, H3K9me3.

30 pression corresponded with deficiencies in 2 repressive chromatin markers, H3K9 dimethylation and H3K

31 Repressive chromatin marks (H3K9me2/3) and transposable

32 ypermethylated genes exhibited enrichment of repressive chromatin marks and reduced expression prior

33 To activate silenced genes, repressive chromatin marks are removed and active marks

34 ication origins that also associate with the repressive chromatin marks H3K9me3 and methylated-CpGs,

35 Furthermore, p53 status correlated with repressive chromatin marks in the 5' sequence of a synth

36 Erasure of DNA methylation and repressive chromatin marks in the mammalian germline lea

37 Furthermore, repressive chromatin marks influence ORCA's binding on c

38 vr1 is associated with reduced levels of the repressive chromatin modification H3K27me3 at VRN1, whic

39 1 that, together, recruit SUV39H1 and induce repressive chromatin modifications in the gene promoter.

40 s ribosomal RNA (rRNA) genes are silenced by repressive chromatin modifications.

41 (-/-) ESCs, indicating that establishment of repressive chromatin on the leading strand following DNA

42 This shift to a repressive chromatin organization may be important to in

43 Disruption of the repressive chromatin over LINE-1 elements in DTPs result

44 CHD4 recruits repressive chromatin proteins to sites of DNA damage rep

45 ependent H3K36 trimethylation to establish a repressive chromatin state in the downstream canonical N

46 eved together with piRNA-mediated changes to repressive chromatin states, and relies on the function

47 modification that warrants inheritance of a repressive chromatin structure during cell division, the

48 NAs in a cooperative manner to form a stable repressive chromatin structure.

49 of transcription and for the maintenance of repressive chromatin.

50 G9a and SETDB1 to the Il17 locus to deposit "repressive" chromatin marks at H3K9 sites, and consequen

51 Polycomb Repressive Complex (PRC) 2 catalyzes the H3K27me3 modifi

52 The dependency on the polycomb repressive complex (PRC2) and EZH2 represents one such v

53 site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is overexpresse

54 Here we show that Polycomb-repressive complex 1 (PRC1) directs timely activation of

55 The essential functions of polycomb repressive complex 1 (PRC1) in development and gene sile

56 119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the compositio

57 Instead, we found that Pc-repressive complex 1 (PRC1) purifies with coactivators F

58 CBX2, a component of the mammalian Polycomb repressive complex 1 (PRC1), contains a compaction regio

59 fied UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex respo

60 Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiqu

61 ferred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1).

62 BX proteins associate with the core Polycomb repressive complex 1 (PRC1).

63 protein Polycomb (Pc), a subunit of polycomb repressive complex 1 (PRC1).

64 ded to locations bound by canonical polycomb repressive complex 1 (PRC1).

65 /2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominantly utilized

66 lation leads to a redistribution of polycomb repressive complex 1 and de-repression of its target gen

67 ontaining proteins CBX4 and CBX6 of polycomb-repressive complex 1 through the removal of K48-linked p

68 6 in cellular reprogramming through polycomb-repressive complex 1.The ubiquitin-proteasome system reg

69 n hepatocytes, EpCAM is silenced by polycomb repressive complex 2 (PRC2) and ZNF198/LSD1/Co-REST/HDAC

70 ted phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embry

71 Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3,

72 transient recruitment of EZH2, the polycomb repressive complex 2 (PRC2) component responsible for H3

73 al dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EED, and SU

74 Polycomb repressive complex 2 (PRC2) controls maintenance and lin

75 Polycomb repressive complex 2 (PRC2) has been shown to play a maj

76 Polycomb repressive complex 2 (PRC2) is a histone methyltransfera

77 Polycomb repressive complex 2 (PRC2) is a key chromatin modifier

78 Polycomb repressive complex 2 (PRC2) is an essential regulator of

79 Polycomb repressive complex 2 (PRC2) is responsible for methylati

80 The Polycomb repressive complex 2 (PRC2) mainly mediates transcriptio

81 Polycomb repressive complex 2 (PRC2) mediates gene silencing thro

82 Polycomb repressive complex 2 (PRC2) methylates lysine 27 in hist

83 Polycomb repressive complex 2 (PRC2) participates in transcriptio

84 sponse elements (PREs), that direct Polycomb repressive complex 2 (PRC2) placement at developmental g

85 ve complex 2 in cell fate decisions.Polycomb repressive complex 2 (PRC2) plays an essential role in d

86 Polycomb repressive complex 2 (PRC2) silences gene expression thr

87 re is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesio

88 that catalyze H3K27me3, namely, the polycomb repressive complex 2 (PRC2) subunits enhancer of zeste 1

89 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes methylation o

90 ethyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expressed in

91 cus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-mediated

92 s SMN2 expression by recruiting the Polycomb Repressive Complex 2 (PRC2) to its locus.

93 ased communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required for normal

94 to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investig

95 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to maintain the

96 H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these loci.

97 logue (SUZ12), which is a domain of Polycomb repressive complex 2 (PRC2), promoting the methylation o

98 te homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met expression

99 on of EZH2 and SUZ12, components of polycomb repressive complex 2 (PRC2), transcriptional activation

100 Here, we show that, in mESCs, the Polycomb repressive complex 2 (PRC2)-associated protein EPOP (Elo

101 ied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trimethylatio

102 reviously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional reg

103 ranscription repression mediated by Polycomb repressive complex 2 (PRC2).

104 Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 a

105 Polycomb repressive complex 2 and the epigenetic mark that it dep

106 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chromatin-re

107 Polycomb repressive complex 2 deficiency impaired clonal expansio

108 Here, we show that a subset of Polycomb repressive complex 2 factors nucleate silencing in a sma

109 Here we report that knockout of polycomb repressive complex 2 genes in human embryonic stem cells

110 pluripotent state-specific roles of polycomb repressive complex 2 in cell fate decisions.Polycomb rep

111 transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.

112 s of the distinct components of the Polycomb repressive complex 2 in the control of skin development

113 In contrast, polycomb repressive complex 2 is dispensable for pluripotency whe

114 receptor signaling and induction of Polycomb Repressive Complex 2 signaling.

115 activity of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), forming repressive

116 tional ablations of three essential Polycomb repressive complex 2 subunits (EED, Suz12, or Ezh1/2) in

117 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 lysine 27

118 ome and contributed to tethering of polycomb repressive complex 2 through physical interaction, thus

119 methyltransferases or of the PRC2 (Polycomb Repressive Complex 2) by pharmaceutical inhibition or si

120 homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene expressio

121 nteracts with Suz12, a component of polycomb repressive complex 2, to promote oligodendrocyte maturat

122 function largely as subunits of the Polycomb repressive complex 2, which is important in the context

123 ciated protein EPOP (Elongin BC and Polycomb Repressive Complex 2-associated protein; a.k.a. C17orf96

124 We further show that polycomb repressive complex 2-deficient mouse embryonic stem cell

125 results demonstrate a dual role for polycomb repressive complex 2-mediated epigenetic silencing in tu

126 g homeobox genes and targets of the Polycomb repressive complex 2.

127 nvoking the increased enrichment of Polycomb Repressive Complex 2.

128 his is achieved by the activity of three PcG repressive complex 2s (PRC2s) and the participation of a

129 We find that the SIN3A co-repressive complex binds to LINE-1s, ensuring their repr

130 Interestingly, targets of polycomb repressive complex in stem cells were mostly affected su

131 It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC-

132 is a component of the multi-subunit polycomb repressive complex PRC2, and the down-regulation of exon

133 , our findings suggest that the failure of a repressive complex to form or stabilize in breast cancer

134 Formation of a repressive complex, defined by the core clock proteins c

135 -catenin, which contribute to PRC2 (polycomb repressive complex-2) binding to promoter regions of cla

136 ession by recruiting the epigenetic Polycomb repressive complex-2.

137 We find that Polycomb repressive complex-active genes have greater cell-to-cel

138 osylate RING1A, a key member of the polycomb repressive complex.

139 n with the nucleosome remodeling deacetylase repressive complex.

140 HETEROCHROMATIN PROTEIN1 (LHP1), a Polycomb Repressive Complex1 (PRC1) subunit.

141 We studied POLYCOMB REPRESSIVE COMPLEX2 (PRC2) in Brassicaceae.

142 homolog (SUZ12), a core subunit of Polycomb repressive complex2 (PRC2), undergoes proteasomal degrad

143 with each other to form chromatin-associated repressive complexes (Polycomb repressive complexes 1 an

144 Polycomb repressive complexes (PRC) are frequently implicated in

145 The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes

146 Polycomb repressive complexes (PRCs) are important histone modifi

147 are known to oppose the activity of Polycomb repressive complexes (PRCs).

148 in-associated repressive complexes (Polycomb repressive complexes 1 and 2) leading to chromatin compa

149 ether Plasmodium changes its translationally repressive complexes and mRNA targets in different stage

150 ion of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear h

151 Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an imp

152 The Polycomb repressive complexes PRC1 and PRC2 play a central role i

153 The Polycomb-repressive complexes PRC1 and PRC2 play a key role in ch

154 DSBs promote rapid accumulation of repressive complexes, including HP1, the NuRD complex, H

155 least in part, by cooperation with Polycomb repressive complexes.

156 nction of eukaryotic initiation factor 3f, a repressive component in the 43S preinitiation complex.

157 ion both during exponential growth and under repressive conditions.

158 maintain the chromatin of muscle genes in a repressive conformation, whereas its down-regulation all

159 (H2AK119Ub1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.

160 and TP53 mutations, 5q and 19p loss and long repressive domains.

161 n of p21 (CDKN1A) and the recruitment of the repressive DREAM complex to the A3B gene promoter, such

162 tion with TPL/TPR co-repressors, whereas the repressive EAR domain is dispensable and the acidic doma

163 ated by autonomous pathway gene FCA, and the repressive effect of FOF2 in flowering can be overcome b

164 Indeed, p70S6K1 inhibition prevented the repressive effect of JNK activation on insulin action in

165 TNPO1 overexpression partially reversed the repressive effect of miR-128 on L1 retrotransposition.

166 various biological scenarios, including the repressive effect of the upstream open reading frames on

167 ors by enhancing 4E-BP1-mediated translation-repressive effect on cell proliferation and tumor growth

168 f latently infected cells, corroborating its repressive effect on NF-kappaB pathway.

169 odel where H2A.Z in gene bodies has a strong repressive effect on transcription, whereas in +1 nucleo

170 matergic neurotransmission recapitulated the repressive effects of augmented maternal care on Crh, an

171 we show that GLE1 expression suppresses the repressive effects of DED1 in vivo and Gle1 counteracts

172 Moreover, it is unclear whether the repressive effects of uORFs are conserved across species

173 sequences for GR or occupancy patterns with repressive effects on transcription.

174 Here, we investigate how the four repressive elements (REs) we have discovered in the CARD

175 red TCR-inducible by the four autoinhibitory repressive elements in the CARD11 inhibitory domain and

176 CARD11 ID contains an unusual array of four repressive elements that function cooperatively with red

177 ust perturb autoinhibition by at least three repressive elements.

178 It generally constitutes a repressive environment, but several genes, including the

179 g to chromatin was accompanied by sequential repressive epigenetic changes which outlasted NRSF bindi

180 RE1 promoter carried increased levels of the repressive epigenetic mark histone 3 lysine 27 trimethyl

181 Surprisingly, the spread of repressive epigenetic marks (histone H3K9me2) to nearby

182 Aberrant PRC2 activity produces gene repressive epigenetic marks in multiple diseases and led

183 Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which

184 omic context and accompanied by increases of repressive epigenetic marks, H3K9me3 and H3K27me3, near

185 DNA methylation is a repressive epigenetic modification that covers vertebrat

186 titutive heterochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and

187 elevating H3K27me3 levels, thus conferring a repressive epigenetic signature at Olig1&2 sites.

188 , a histone methyltransferase that defines a repressive epigenetic signature, in defining the transcr

189 cal domains and their states (e.g. active or repressive) for 98 additional cell types from Roadmap Ep

190 These results demonstrate the repressive function of FHL2 on TGF-beta1 expression and

191 nonproliferative diabetic retinopathy and a repressive function of let-7 in pathological angiogenesi

192 We confirmed the repressive function of MYBL1 through stable transformati

193 The repressive function of Myt1l is mediated via recruitment

194 rlying the transition between a better-known repressive function of PTBP1 and its role as a bona fide

195 proximal limb mesenchyme and antagonizes the repressive function of TALE factors in osteogenesis.

196 This TPL interaction confers a repressive function on CDF1, as mutations of the N-termi

197 binding to the Sf1 promoter region, and the repressive function was completely abolished when WT1 bi

198 In agreement with its repressive function, the genomic binding sites of Myt1l

199 These findings reveal new "anti-repressive" function for hundreds of tissue-specific enh

200 /SNF chromatin-remodeling complex with known repressive functions in HIV-1 transcription.

201 They perform activation and repressive functions in the regulation of gene expressio

202 s have distinguishable tumorigenic and tumor-repressive functions.

203 e that actively enables transcription across repressive GAA repeats that silence frataxin expression

204 m open reading frames (uORFs) are ubiquitous repressive genetic elements in vertebrate mRNAs.

205 in most human somatic cells results from its repressive genomic environment, providing new insight in

206 repressive complex 2 subunit (EZH2), forming repressive H3K27(me3) marks.

207 e the active H3K4me4 and H3K36me3 as well as repressive H3K27me3 appeared together.

208 -associated H3K4me3 marks and an increase in repressive H3K27me3 marks within the promoters occupied

209 entiation, Pask stimulates the conversion of repressive H3K4me1 to activating H3K4me3 marks on the pr

210 tric dimethylation of H3R17 while preventing repressive H3K9 trimethylation and hence further modifyi

211 chanistically, KDM3 not only directly erases repressive H3K9me2 marks, but also helps to recruit hist

212 nase, which can respectively demethylate the repressive H3K9me3 mark and phosphorylate the activating

213 inheritance of endo-siRNAs and deposition of repressive H3K9me3 marks at target loci.

214 ionally active chromatin and lower levels of repressive hallmarks.

215 Repressive heterochromatin domains silence expression of

216 ila melanogaster is characterized by loss of repressive heterochromatin structure and loss of silenci

217 lly required genes, lead to the formation of repressive heterochromatin, or aid in DNA and chromatin

218 Polyamides can access cognate sites within repressive heterochromatin.

219 cG targets by linking PRC1 to formation of a repressive higher-order structure.

220 directly linked to VEGFA-induced release of repressive histone deacetylases and concurrent recruitme

221 We show that MeCP2, like the repressive histone H1, traps the nucleosome in a more co

222 consequences of shifting the balance of the repressive histone H3 lysine 27 trimethylation (H3K27me3

223 of subtelomeric genes and alteration of the repressive histone H3 lysine 9 methylation (H3K9me) land

224 While inducing pro-invasive genes by erasing repressive histone H3 lysine 9 methylation, KDM3A promot

225 H, and is not attributable to differences in repressive histone H3K9me3 or H3K27me3 levels.

226 a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency.

227 yonic stem cells (ESCs), accumulation of the repressive histone mark H3K27me3 is delayed after DNA re

228 genous loci, accompanied by elevation in the repressive histone mark H3K9me2 and by reduction in RNA

229 1 directly occupies ERVs and is required for repressive histone mark H3K9me3 and H3K27me3 assembly an

230 ated with gene silencing, and increases in a repressive histone mark, H3K9me2.

231 ng to chromatin and reduced global levels of repressive histone marker H3K27 trimethylation.

232 tion and is accompanied by the deposition of repressive histone marks and methylation of the integrat

233 f the MLV promoter through the deposition of repressive histone marks as well as DNA methylation.

234 ansposon activation, while the deposition of repressive histone marks follows as a chronic response.

235 tudies further demonstrated an enrichment in repressive histone marks on the miR-196b promoter during

236 nied by altered distribution patterns of the repressive histone marks trimethylation on lysine 27 of

237 larity, and largely overlapped with reported repressive histone marks.

238 rs, including ATR, gammaH2AFX, and canonical repressive histone marks.

239 scriptional silencing and is associated with repressive histone methylation (H3K9me).

240 Clemastine induced higher levels of repressive histone methylation (H3K9me3), a marker for h

241 yltransferase Ehmt2 (G9a) led to the loss of repressive histone methylation at the Nedd4-1 promoter a

242 accompanied by widespread redistribution of repressive histone methylation.

243 w that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 ly

244 ar protein PARP1, leading to a decrease in a repressive histone modification, accompanied by inductio

245 SET domain and thus the propagation of this repressive histone modification.

246 Our results suggest that so-called repressive histone modifications are not sufficient for

247 undetermined combinations of activating and repressive histone modifications) were enriched for CTCF

248 However, the roles of repressive histone modifications, such as trimethylated

249 s H3K4-me2/3, and subsequent accumulation of repressive histone modifications.

250 ar transport of SHP and its interaction with repressive histone modifiers to inhibit BA synthetic gen

251 d by both H3K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of

252 cquisition of DNA methylation, and the added repressive influence of polycomb at a subset of CG-dense

253 The specific outcome is selected by repressive input provided by Shh-induced transcription f

254 COLDAIR and COLDWRAP are required to form a repressive intragenic chromatin loop at the FLC locus by

255 fferences, we detected higher amounts of the repressive mark H3K27me3 in the external layers, compare

256 summary, we demonstrated that removal of the repressive mark H3K27me3 is essential for the induction

257 Through its repressive mark H4K20me3, SUV420H2 silences several key

258 2 mRNA levels and increased association of a repressive mark on histones (H3K9me3) at the FGF2 promot

259 o caused a widespread redistribution of this repressive mark, including a loss of H3K27me3 that was a

260 xpression depends on enhancers clearing this repressive mark.

261 A (H2AUb1) is a reversible transcriptionally repressive mark.

262 Further, ORCA directly associates with the repressive marks and interacts with the enzymes that cat

263 gulator mutations, and by mapping active and repressive marks in purified human hematopoietic stem ce

264 The structure also reveals how binding of repressive marks, like H3K27me3, to the EED subunit of t

265 e complex 2 and the main writer of chromatin-repressive marks.

266 and degradation, blocking recruitment of the repressive Mbd3/nucleosome remodeling and deacetylase (N

267 This dual repressive mechanism reverts upon nutrient addition, thu

268 , thereby demonstrating the need for further repressive mechanisms by anti-inflammatory glucocorticoi

269 have revealed roles of miRNAs and other gene repressive mechanisms in development or other cellular p

270 ssues of Arabidopsis (Arabidopsis thaliana), repressive methylation marks are enriched in FIS2 and ME

271 s a histone demethylase with specificity for repressive modifications.

272 We conclude that repressive motifs are strongest next to cryptic exons an

273 ides, and distinguished known activating and repressive motifs.

274 ssion of the gene through the binding of the repressive MYB transcription factor and, consequently, a

275 a SUMOylation, which causes recruitment of a repressive NCOR/HDAC3 complex to the IL-10 promoter, but

276 cription toward the heterochromatin-enriched repressive nuclear compartments in p63-null cells.

277 nexpected antagonistic interplay between two repressive pathways involved in retroviral silencing in

278 pendent communication between PRC1 and PRC2, repressive Polycomb chromatin domains can erode, renderi

279 ke-induced chromatin changes include initial repressive polycomb marking of genes, later manifesting

280 In contrast, regions associated with the repressive Polycomb-Group showed low turnover in ESCs.

281 lation of HSF1 at S303/307, previously known repressive posttranslational modifications.

282 erpes simplex virus (HSV) DNA is coated with repressive proteins and becomes the site of assembly of

283 scription factors AtWRKY15 and AtWRKY40 have repressive regulatory roles in this touch-responsive gen

284 size and number of eyespots, illustrating a repressive role for this gene in eyespot development.

285 These data suggest that H2A.Z has a repressive role in transcription and counteracts unwante

286 tor of conidiation brlA, indicating a direct repressive role of NsdD in conidiation.

287 oles, and uncovered 'attenuator' motifs with repressive roles in active chromatin.

288 n the delicate balance between inductive and repressive signals induces the normal GnRH-fuelled run-u

289 nced prostate cancers upon reversion of both repressive signals.

290 H3K27, thereby switching the transcriptional repressive state to the active state at the promoters of

291 (NSCs) and occupy black chromatin and a TrxG-repressive state.

292 The repressive status of chromatin largely contributes to HI

293 Thus, nucleosomes are not exclusively repressive to gene regulation when they are retained wit

294 vious research has identified many active or repressive transcription factors (TFs) and core transcri

295 demethylase family participates in multiple repressive transcriptional complexes at promoters and ha

296 R genes are decorated with transcriptionally repressive trimethylated histone 3 lysine 9 (H3K9me3) wh

297 TX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27

298 In this study we found that Pum1 was auto-repressive under growth as yeast, but that auto-repressi

299 s amenable to regulation over constitutively repressive uORFs/oORFs.

300 We also show that orthogonal repressive versions of this mechanism can be created thr