ライフサイエンスコーパス: the molecular basis of

1 We sought to investigate the molecular basis of 3 pustular skin disorders: genera

2 Our data not only revealed the molecular basis of ACT biosynthesis but also provide

3 In this article, we focus mainly on the molecular basis of activation and drug modulation of

4 Recent major advances in understanding the molecular basis of acute myeloid leukemia (AML) prov

5 n different lineages has been used to define the molecular basis of acute virulence in the mouse.

6 paradigm of the ground work needed to tackle the molecular basis of all the protein-aggregation-relat

7 yloid peptide Abeta are needed to understand the molecular basis of Alzheimer's disease and develop t

8 model may provide a better understanding of the molecular basis of Alzheimer's disease at atomic res

9 pins and may offer a deeper understanding of the molecular basis of Alzheimer's disease.

10 Our study therefore reveals the molecular basis of an interaction that is crucial fo

11 The crystal structure provides insight into the molecular basis of antibody-carbohydrate interaction

12 ce containing high quality reference data on the molecular basis of antimicrobial resistance (AMR), w

13 These findings elucidate the molecular basis of antiviral mechanism and HIV-Vif t

14 n essential step toward the understanding of the molecular basis of apoptosis and inflammation.

15 nctionally important insertions, and reveals the molecular basis of AR-JP-causing mutations, some of

16 We describe recent progress made in defining the molecular basis of artemisinin resistance, which has

17 t of the NSs core domain in crystals reveals the molecular basis of assembly of this key virulence fa

18 r atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may faci

19 ajor breakthroughs have been made dissecting the molecular basis of auxin transport, perception, and

20 itations curtailed our ability to understand the molecular basis of bacterial cell size control.

21 This establishes the molecular basis of binding of a highly selective non

22 To elucidate the molecular basis of BMP4-induced differentiation of h

23 roup is present may provide new insight into the molecular basis of bone calcium mobilization induced

24 model will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the

25 es (Abs) from immune subjects to investigate the molecular basis of broadly neutralizing antibody res

26 To understand the molecular basis of Ca(2+) binding and open-state sta

27 However, the molecular basis of cancer preventive functions of zi

28 essential to advancing our understanding of the molecular basis of cancer.

29 These findings provide insights into the molecular basis of cardiac reprogramming and represe

30 microRNAs (miRNAs) play an important role in the molecular basis of caste determination and different

31 A powerful approach is to compare the molecular basis of caste determination and different

32 Understanding the molecular basis of cell wall metabolism in sugarcane

33 tus is a premier model organism for studying the molecular basis of cellular asymmetry.

34 To elucidate the molecular basis of charge selectivity for the superf

35 First, we wished to determine the molecular basis of cholesterol homeostatic responses

36 ical disorder chilling injury (CI); however, the molecular basis of CI development remains largely un

37 R functions and provide a model for studying the molecular basis of cnidarian disease and immunity.

38 esis model accounts for adult-onset disease, the molecular basis of congenital DM (CDM) is unknown.

39 ctability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin functio

40 indings lay the foundation for understanding the molecular basis of coupling selectivity within indiv

41 that regulate these processes and illuminate the molecular basis of crosstalk between synapses.

42 Here, we characterize the molecular basis of Cu(+) entry using molecular-dynam

43 The molecular basis of cystic fibrosis (CF) is a mutatio

44 ings establish a framework for understanding the molecular basis of cytochrome c-mediated blocking of

45 To elucidate the molecular basis of DHAR catalysis, we determined the

46 The molecular basis of differences between larval and ad

47 henotype correlations, insights gleaned into the molecular basis of disease, and available therapeuti

48 uctural basis of receptor function and about the molecular basis of disease-associated single nucleot

49 amental understanding of structural biology, the molecular basis of diseases, and possible routes to

50 healthy subjects, can provide insights into the molecular basis of diseases.

51 re of associated SNPs and interpretations of the molecular basis of diseases.

52 n structures are essential for understanding the molecular basis of diverse biological events and imp

53 n and provide a foundation for understanding the molecular basis of diverse cytoskeleton-dependent pr

54 We report the molecular basis of DNA-binding autoinhibition of ETS

55 However, the molecular basis of Eco1 substrate recognition and ac

56 invadens Dissection of the molecular basis of Entamoeba stage conversion is now

57 ations in ENU-induced malignant schwannomas, the molecular basis of ENU-induced gliomas remains enigm

58 The molecular basis of enzyme catalytic power and specif

59 for the drug metformin with implications for the molecular basis of epigenetic dysregulation in cance

60 d will help frame future investigations into the molecular basis of ER-driven neuronal disease states

61 The molecular basis of eRF1 discrimination for stop codo

62 This structure revealed the molecular basis of Erve virus vOTU's preference for

63 To study the molecular basis of facilitated dissociation (FD), we

64 Our results explain the molecular basis of FF-induced glioblastoma cytotoxic

65 This work expands our understanding of the molecular basis of fibre formation laying the founda

66 gellar filaments, and begin to shed light on the molecular basis of filament switching.

67 nt data towards genome-wide understanding of the molecular basis of FLC resistance in T. asahii.

68 ovides the 'toolbox' genes for understanding the molecular basis of flower color diversification in n

69 ics simulation in order to better understand the molecular basis of food protein allergenicity.

70 of genome-wide assays, our understanding of the molecular basis of genomic disorders, specifically t

71 xic agent methyl methanesulfonate (MMS), but the molecular basis of genotoxic stress is unclear.

72 1 complex is a crucial step in understanding the molecular basis of glycoprotein quality control but

73 imetics could be used as a platform to study the molecular basis of GPCR/G protein recognition.

74 another distinct process that contributes to the molecular basis of graphene cytotoxicity.

75 on in the fetal cortex has been suggested as the molecular basis of handedness.

76 that spinal gene expression asymmetries form the molecular basis of handedness.

77 These findings highlight the molecular basis of HCS pathogenesis and provide clin

78 scopy to near-atomic resolution, elucidating the molecular basis of helicase function by relaxases an

79 prominent role in lysosome pathophysiology, the molecular basis of hENT3-mediated transport is unkno

80 reflection of an incomplete understanding of the molecular basis of HNSCC pathogenesis.

81 However, the molecular basis of host defense against disseminated

82 view summarizes our current understanding of the molecular basis of host specificity in the Xanthomon

83 The molecular basis of how cargo engagement affects the

84 to longevity in Caenorhabditis elegans, but the molecular basis of how chromatin structure modulates

85 The molecular basis of how hydrophobic signals within a

86 The molecular basis of how Mtb impairs T-cell function i

87 croscopy and biochemical analysis, we define the molecular basis of how phosphorylation of human APC/

88 Our results define the molecular basis of how PIK3CD and PIK3R1 mutations r

89 d tumorigenesis in vivo Our findings uncover the molecular basis of how the metabolism of myristic ac

90 The molecular basis of how the N-terminal non-catalytic

91 However, the molecular basis of how these endosomal NHEs control

92 However, the molecular basis of how these two highly homologous g

93 ll explored, currently much is unknown about the molecular basis of HUWE1-promoted XLID.

94 To ascertain the molecular basis of ichthyosis patients in Iran, a co

95 We sought to establish the molecular basis of IL-13 overproduction by CD8(+) T

96 These findings illuminate the molecular basis of IMAC enrichment at microvillar ti

97 lens is a powerful system for investigating the molecular basis of inductive tissue interactions and

98 This review will focus on understanding the molecular basis of inflammasomes, recognizing the di

99 gulated in response to physiologic cues, and the molecular basis of inherited diseases characterized

100 hibits RNAPII transcription, suggesting that the molecular basis of inhibition is conserved between a

101 currently in clinical development, although the molecular basis of inhibitor recognition remains unk

102 This study investigated the molecular basis of insecticide resistance in Malaysi

103 Understanding the molecular basis of insecticide resistance is key to

104 omain binding partners have been identified, the molecular basis of interactions with the C-terminal

105 iants to provide a framework for teasing out the molecular basis of interfacial self-assembly.

106 Our structure reveals not only the molecular basis of ion conduction but also the uniqu

107 Understanding the molecular basis of IRD is vital for clinical and gen

108 Our results provide the first insights into the molecular basis of its action and impact on Streptom

109 sarcomere that are strongly bound to actin, the molecular basis of its action is still not completel

110 le-3-propanoate (T-0632), and exploration of the molecular basis of its binding.

111 ree-dimensional structure is unavailable and the molecular basis of its permeation function is unknow

112 However, the molecular basis of its unique product specificity ha

113 Deciphering the molecular basis of leukocyte recruitment is critical

114 Understanding the molecular basis of ligand binding to receptors provi

115 Previous work has discussed the molecular basis of maize - C. graminicola interactio

116 Uncovering the molecular basis of mammalian cardiomyocyte prolifera

117 ulted in an increase in our understanding of the molecular basis of many primary immune deficiencies.

118 Our results provide insights into the molecular basis of mechanotransduction in a tactile-

119 However, the molecular basis of metastatic breast cancer and its

120 S) have provided unprecedented insights into the molecular basis of microbial phenotypes and enabled

121 ial tethering, and our results shed light on the molecular basis of mitochondrial fusion and mitofusi

122 urthermore, it offers fundamental clues into the molecular basis of MMP regulation by N-TIMP2 and ide

123 The molecular basis of most pustular skin conditions has

124 ructures at high resolution, we investigated the molecular basis of MotA, SocA, and AttC interactions

125 the ontogeny of OSM progenitors and compare the molecular basis of Mrf activation in OSM versus ASM.

126 annel activation, and provides insights into the molecular basis of mucolipidosis type IV pathogenesi

127 To gain insights into the molecular basis of mutant TG6-induced neurotoxicity,

128 AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter card

129 Recent studies have revealed the molecular basis of mycobacterial lipid recognition b

130 omixer partnership and provide insights into the molecular basis of myoblast fusion.

131 volution, clone emergence and expansion, and the molecular basis of niche adaptation.

132 intense investigation, no general model for the molecular basis of nonadditive genetic variance has

133 This review focuses on the molecular basis of Notch-induced signaling and its i

134 The molecular basis of NSAID inhibition of ASICs has rem

135 Understanding the molecular basis of nSH3:PRM interaction will provide

136 oncentrations and provide an explanation for the molecular basis of observed adverse effects of neoni

137 These findings provide new information on the molecular basis of OCD and suggest new avenues for i

138 These findings provide insights into the molecular basis of oleic acid inhibition of TRPV1 an

139 Little is known about the molecular basis of pathogenesis in B. cookei, in lar

140 mination and investigation were performed of the molecular basis of patient's skin fragility and mott

141 Although our understanding of the molecular basis of pediatric cardiomyopathy has impr

142 We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor r

143 ange in DC function was developed to dissect the molecular basis of persistent IDO expression in post

144 ar transcriptome demonstrated herein defines the molecular basis of photoreceptor architecture and fu

145 A more thorough understanding of the molecular basis of plant biomass traits should provi

146 pproach should prove useful for the study of the molecular basis of plasticity in the dorsolateral st

147 ochemical characterizations, we investigated the molecular basis of PME3 inhibition by PMEI7 in Arabi

148 further exploring multitarget activities and the molecular basis of polypharmacology.

149 This review focuses on the molecular basis of posttranslational regulation of e

150 kbone reconfiguration as a way to understand the molecular basis of prion aggregation.

151 ructure, which is critical for understanding the molecular basis of prion infectivity.

152 Although the molecular basis of prion strains is not fully unders

153 Amyloid polymorphs may be the molecular basis of prion strains.

154 Our findings identify the molecular basis of proofreading in bacteria, highlig

155 Currently the molecular basis of protein degradation for CLC-1 cha

156 ant challenges with respect to understanding the molecular basis of protein/membrane interactions.

157 diversity analyses, we show that a shift in the molecular basis of pyrethroid resistance in southern

158 serious attention for full understanding of the molecular basis of Rab GTPase-regulated membrane tra

159 Here, we overview the molecular basis of racial disparity in cancer suscep

160 State-of-the-art knowledge of the molecular basis of RCC and its treatment and imaging

161 We identified the molecular basis of recognition of the C-terminal seq

162 te as alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition fr

163 s the emerging need to more fully understand the molecular basis of residual disease as a prelude to

164 ICB) is revolutionizing cancer medicine, yet the molecular basis of resistance remains unclear.

165 ip between these different roles, as well as the molecular basis of Rif1 function is still unclear.

166 Rj4 gene is the first step in understanding the molecular basis of Rj4-mediated nodulation restricti

167 rocess of Ca(2+)-induced Ca(2+) release, but the molecular basis of RyR2 activation by cytosolic Ca(2

168 However, the molecular basis of SCN CC insensitivity to RF and it

169 To determine the molecular basis of selectivity we generated a series

170 However, the molecular basis of silicic acid transport remains ob

171 scle formation will not only help to unravel the molecular basis of skeletal muscle diseases, but als

172 , providing a tractable model to investigate the molecular basis of skin appendage differences.

173 Improved understanding of the molecular basis of SMA, disease pathogenesis, natura

174 tional protease specificity profiling reveal the molecular basis of some of these changes.

175 to one of the most potent compounds reveals the molecular basis of specificity.

176 Our results provide insights into the molecular basis of sperm-egg recognition, cross-spec

177 ion strains, making current understanding of the molecular basis of strains and phenotypic variabilit

178 However, current understanding of the molecular basis of subclass conversion that is often

179 play critical roles in BIA biosynthesis, but the molecular basis of substrate recognition and catalys

180 However, the molecular basis of such a radiation induced effect i

181 To investigate the molecular basis of such attributes, we present here

182 ay key roles in development and disease, yet the molecular basis of such differential signaling remai

183 Here we review the molecular basis of such events from a mechanistic pe

184 To investigate the molecular basis of such regularity, mutants with alt

185 regulated by extracellular protons; however, the molecular basis of such regulation remains unidentif

186 stems have been extensively used to decipher the molecular basis of such regulatory cascades, and one

187 To examine the molecular basis of such variation, we studied the ge

188 CCK1R/CCK2R constructs were used to explore the molecular basis of T-0632 binding.

189 To investigate the molecular basis of TAD formation, we performed Hi-C

190 Here we elucidate the molecular basis of TCS mutations in Saccharomyces ce

191 ne components on pol II transcription reveal the molecular basis of template recognition during pol I

192 The molecular basis of the affinity of 627-NLS for impor

193 To decipher the molecular basis of the allelochemical activity of MD

194 nal mutant CAL027_01_20 was used to identify the molecular basis of the classical C. reinhardtii muta

195 ontribute to furthering the understanding of the molecular basis of the corneal epithelium specific p

196 o interact with FOR20 and OFD1, which may be the molecular basis of the defect.

197 However, understanding the molecular basis of the disease has been impaired by

198 ions in patients with sporadic ALS; however, the molecular basis of the disease mechanism is not yet

199 ers is a current limitation to understanding the molecular basis of the diverse specificity observed

200 tribution to healthy aging and longevity and the molecular basis of the DNA methylation clock.

201 However, the molecular basis of the down-regulatory effect of TUL

202 These findings establish the molecular basis of the extracellular function of ISG

203 stages of the pathways are well elucidated, the molecular basis of the first stage-the serylation of

204 These data reveal the molecular basis of the formation of 'sticky fingers'

205 s, and nonpermissive lipid ligands clarifies the molecular basis of the frequently observed but poorl

206 , simulations, and experiments to understand the molecular basis of the function of Lecsl.

207 The molecular basis of the function of transporters is a

208 The molecular basis of the incomplete penetrance of mono

209 of the G1MDR-mediated silencing machinery is the molecular basis of the initial activation of the Gat

210 dylcholine-liposomes, has been reported, but the molecular basis of the interaction between NM2s and

211 c force microscopy imaging, we characterized the molecular basis of the interaction of CsgB with a me

212 Here we investigate the molecular basis of the interaction of RNA with LAF-1

213 Understanding the molecular basis of the IS provides critical informat

214 those given in earlier reports, illuminating the molecular basis of the JAK-cytokine receptor associa

215 ly, we discovered the disruption of Scyl1 as the molecular basis of the mouse mutant mdf, which is af

216 -restricted autoreactivity, thus elucidating the molecular basis of the observed V gene bias.

217 However, the molecular basis of the opposite actions of tomato GL

218 The molecular basis of the optical properties of chromop

219 The molecular basis of the purported functional differen

220 the CD4-17b-induced intermediate and provide the molecular basis of the receptor-binding-induced conf

221 Defining the molecular basis of the role of RSV F in pathogenesis

222 study provide a framework for understanding the molecular basis of the sleep-wake state-dependent co

223 ructures of PDE6delta/cargo complexes reveal the molecular basis of the sorting signal which depends

224 cturing the catalytic pocket and illustrated the molecular basis of the substrate specificity.

225 sodium/aspartate symporter GltPh, suggested the molecular basis of the transporter cycle.

226 ein translocation across membranes revealing the molecular basis of the unconventional secretory path

227 Understanding the molecular basis of the vernalisation requirement in

228 tive treatments requires an understanding of the molecular basis of their disease.

229 rotease enzymes is critical for illuminating the molecular basis of their diverse and complex roles i

230 To better understand the molecular basis of their function, we have character

231 s emphasizes the importance of understanding the molecular basis of their function.

232 many insects, but their behavioral roles and the molecular basis of their hygrosensitivity remain unc

233 complexes with TCA1 derivatives to elucidate the molecular basis of their inhibitory activities and a

234 However, little is known about the molecular basis of their intrinsic cellular plastici

235 cally interconnected and interdependent, but the molecular basis of their mutual regulation has only

236 om the TCGA-COAD database gave insights into the molecular basis of their phenotypic changes.

237 owth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are

238 ts to the important regulatory role of DUBs, the molecular basis of their regulation is still not wel

239 of the principal nuclear import pathways and the molecular basis of their regulation.

240 tal roles in biology and RNA metabolism, but the molecular basis of their structure, assembly, and fu

241 iculture to deliver increases in yields, yet the molecular basis of their superior performance (heter

242 Understanding the molecular basis of thermoadaptation has progressed i

243 To reveal the molecular basis of these associations and to provide

244 Elucidating the molecular basis of these effects, mutation of four p

245 able progress has been made in understanding the molecular basis of these genetically heterogeneous c

246 In order to understand the molecular basis of these MYB-associated changes, we

247 To understand the molecular basis of these observations, we compare th

248 Knowledge of the molecular basis of these rhythms has exploded in the

249 re is hardly any information available about the molecular basis of this adaptation.

250 The molecular basis of this aggressive phenotype is unkn

251 To understand the molecular basis of this architecture, we examined th

252 PP1 also associates with NCX1; however, the molecular basis of this association is unknown.

253 However, the molecular basis of this co-occurrence, and whether i

254 Although the molecular basis of this constitutive JAK/STAT signal

255 ating BR and autophagy pathways and identify the molecular basis of this crosstalk.

256 of physiological and cellular functions, but the molecular basis of this decline remains unclear.

257 To determine the molecular basis of this deficiency we have investiga

258 c, and biochemical approaches to investigate the molecular basis of this difference and identify resi

259 However, the molecular basis of this early malignant susceptibili

260 lting fluid forces in shaping the heart, yet the molecular basis of this function is largely unknown.

261 However, the molecular basis of this gene-environment mechanism h

262 tween neuronal cell types, but in most cases the molecular basis of this heterogeneity is unknown.

263 RNA processing, thus revealing one aspect of the molecular basis of this human disease.

264 ) in crop fields and natural ecosystems, but the molecular basis of this humidity effect is not under

265 ime control now enables the investigation of the molecular basis of this important variation.

266 To study the molecular basis of this inhibition, we generated GST

267 accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly u

268 s currently available vary considerably, and the molecular basis of this is unclear.

269 The molecular basis of this learning mechanism could be

270 linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear.

271 However, the molecular basis of this long-distance shoot-root coo

272 n this study, we have attempted to determine the molecular basis of this paradox.

273 onomy are only now being elucidated, whether the molecular basis of this phenomenon is the result of

274 d Brownian Dynamics simulations to determine the molecular basis of this phenotype.

275 We investigated the molecular basis of this process in the adenosine A2A

276 timal recruitment of BRCA1 to DSBs, although the molecular basis of this process is not well understo

277 However, the molecular basis of this process remains unknown.

278 To understand the molecular basis of this region-specific variability

279 We address the molecular basis of this regulation using crystallogr

280 9 through its effector calmodulin (CaM), but the molecular basis of this regulation was previously un

281 esistance toward many kinase inhibitors, and the molecular basis of this resistance remains poorly un

282 The molecular basis of this shift, however, remains most

283 is toxic for yeast and mammalian cells, but the molecular basis of this toxicity is poorly understoo

284 So far, the molecular basis of this tripartite relationship and

285 Unravelling the molecular basis of TLR1 and TLR6-driven heterodimeri

286 ficantly contributed to our understanding of the molecular basis of trainability.

287 o complex traits and at the same time reveal the molecular basis of trait variation.

288 The molecular basis of transgene susceptibility to silen

289 Despite its pivotal physiological role, the molecular basis of TRPV1 activation and deactivation

290 To better understand the molecular basis of tung tree chloroplasts, we sequen

291 CD1a-urushiol (C15:2) complex, demonstrating the molecular basis of urushiol interaction with the ant

292 a/d-Ala-d-Lac binding that directly overcome the molecular basis of vancomycin resistance, peripheral

293 However, the molecular basis of viral pathogenesis remains poorly

294 tropism of EAV is critical for understanding the molecular basis of viral persistence and for develop

295 ng as the viral transcriptional template, is the molecular basis of viral persistence.

296 ovide valuable information for understanding the molecular basis of virus neutralization.

297 Our results help to elucidate the molecular basis of voltage sensing and establish str

298 The molecular basis of vulnerability to stress during th

299 ents at the nanoscale provides insights into the molecular basis of wetting.

300 Understanding the molecular basis of zinc (Zn) uptake and transport in