ライフサイエンスコーパス: therapeutic modality

1 mization and broader application of this new therapeutic modality.

2 sses established the broad potential of this therapeutic modality.

3 ration of (90)Y microspheres is an effective therapeutic modality.

4 cts of the tumor microenvironment limit this therapeutic modality.

5 oon prove to be an important and widely used therapeutic modality.

6 and cardiovascular disease, and a potential therapeutic modality.

7 tion of development of these structures as a therapeutic modality.

8 ts further exploration in vivo as a putative therapeutic modality.

9 se of RNAi in gene function studies and as a therapeutic modality.

10 eitis is becoming recognized as an important therapeutic modality.

11 sibility of siRNA as a clinically applicable therapeutic modality.

12 fancy despite its potential as an attractive therapeutic modality.

13 Thereby, siRNA offers promise as a novel therapeutic modality.

14 cial to making radioimmunotherapy a standard therapeutic modality.

15 hypoxia markers may influence the choice of therapeutic modality.

16 ncer, and radiation reactions may limit this therapeutic modality.

17 sing chemotherapy, as a potential definitive therapeutic modality.

18 fic down-regulation can serve as an improved therapeutic modality.

19 % confidence interval, 0.29-0.48; P<0.00001) therapeutic modality.

20 point to targets in the development of novel therapeutic modalities.

21 ng approach towards the development of novel therapeutic modalities.

22 tors of Taspase1 as a new candidate class of therapeutic modalities.

23 lar, have been tested in both preventive and therapeutic modalities.

24 both of which must be addressed by effective therapeutic modalities.

25 lymphoma and melanoma status and associated therapeutic modalities.

26 stic nanoparticles, combining diagnostic and therapeutic modalities.

27 sis should suggest strategies for developing therapeutic modalities.

28 may have implications in the development of therapeutic modalities.

29 vance opportunities to safely pursue them as therapeutic modalities.

30 fluence the acceptance of minimally invasive therapeutic modalities.

31 ural course seems to be ideal for evaluating therapeutic modalities.

32 h adaptations may enhance development of new therapeutic modalities.

33 most common allergens and discusses various therapeutic modalities.

34 rgeted NPs as highly selective and effective therapeutic modalities.

35 e significant effect on the response to such therapeutic modalities.

36 hogenesis, and responses to new and evolving therapeutic modalities.

37 sease and thereby to rational application of therapeutic modalities.

38 rgets for the development of antiproteinuric therapeutic modalities.

39 linical course and intense resistance to all therapeutic modalities.

40 er immunotherapy fuels the need for improved therapeutic modalities.

41 ent strategies encompassing a broad range of therapeutic modalities.

42 application of small-molecule inhibitors in therapeutic modalities.

43 gressive disease refractory to most existing therapeutic modalities.

44 as single agent or in combination with other therapeutic modalities.

45 cantly with the advent of new diagnostic and therapeutic modalities.

46 athogenesis and preclinical testing of novel therapeutic modalities.

47 rosis and fibrosis) as well as a key for new therapeutic modalities.

48 th existing chemotherapeutic drugs and other therapeutic modalities.

49 erm adverse effects than currently available therapeutic modalities.

50 E7, or heat shock proteins have been made as therapeutic modalities.

51 s of psoriasis and insights to develop novel therapeutic modalities.

52 nt of improved diagnostic, prophylactic, and therapeutic modalities.

53 will incorporate a variety of diagnostic and therapeutic modalities.

54 ing approach to develop novel preventive and therapeutic modalities.

55 , it is critical to find new target-specific therapeutic modalities.

56 agnostic and prognostic strategies and novel therapeutic modalities.

57 and highly resistant to currently available therapeutic modalities.

58 FN signals will help in designing additional therapeutic modalities.

59 for assessing the clinical potential of some therapeutic modalities.

60 s of antibody fragments with applications as therapeutic modalities.

61 is incurable, highlighting the need for new therapeutic modalities.

62 il organ recovery and as a bridge to further therapeutic modalities.

63 ergy between checkpoint modulation and other therapeutic modalities.

64 otential benefits and limitations of various therapeutic modalities.

65 potency and/or efficacy of prophylactic and therapeutic modalities.

66 nts of allergenicity, and ways of developing therapeutic modalities against newly identified targets.

67 ting the potential of siRNA as an additional therapeutic modality against HCV infection.

68 data support the use of sorafenib as a novel therapeutic modality against human multiple myeloma, and

69 orting the candidacy of probiotics as such a therapeutic modality against obesity and diabetes.

70 on of miR-383 expression may be an effective therapeutic modality against PCa.

71 her development of antisense technology as a therapeutic modality against tuberculosis.

72 cell activation and the increasing number of therapeutic modalities aimed at manipulating the CD28/CT

73 mia biology and for the development of novel therapeutic modalities aimed at modifying the hematopoie

74 isms of aging and aid in the design of novel therapeutic modalities aimed at prevention and regressio

75 ese results may lead to the development of a therapeutic modality aiming at abrogating Gal-3 transloc

76 ocol results in significant empirical use of therapeutic modalities and a moderately effective treatm

77 ummarize relevant information on the various therapeutic modalities and controversies involved in the

78 nform the development of safe HPbetaCD-based therapeutic modalities and may enable engineering HPbeta

79 l transplantation recipients with a focus on therapeutic modalities and outcomes.

80 often associated with resistance to standard therapeutic modalities and poor survival.

81 patient tumors by prognosis and response to therapeutic modalities and to identify the drivers of tu

82 d endpoints in trials should incorporate the therapeutic modality and cancer type because these facto

83 Ionizing radiation is a common therapeutic modality and following irradiation dermal ch

84 the expanding spectrum of cross-linking as a therapeutic modality and its complications.

85 ophin up-regulation offers a pharmacological therapeutic modality and obviates many of the toxicity a

86 internalization of receptors can be a useful therapeutic modality and the article by Wu et al. illust

87 ical examination, differential diagnosis and therapeutic modalities) and technical skills.

88 hotodynamic therapy (PDT) is now an approved therapeutic modality, and induction of vascular endothel

89 l practice to treat such tumor masses, these therapeutic modalities are always associated with substa

90 Therapeutic modalities are manifold, primarily because n

91 At such an advanced stage, therapeutic modalities are often inadequate.

92 Accurate early diagnosis and new therapeutic modalities are therefore urgently needed.

93 r cell transplantation may prove useful as a therapeutic modality as well as an analytical tool.

94 ity of care, communication as an ethical and therapeutic modality, assistance with emotional, social

95 has yet to provide a cure, and there are few therapeutic modalities available for patients with advan

96 appraisal of the underlying pathogenesis and therapeutic modalities available for PV.

97 ortality in the United States, the number of therapeutic modalities available for the treatment of ne

98 per gastrointestinal bleeding and understand therapeutic modalities available in achieving hemostasis

99 Most therapeutic modalities available or under development ta

100 treating metastatic malignant melanoma with therapeutic modalities based on gene expression profilin

101 ts, immunotherapy is emerging as a plausible therapeutic modality because of the recent advances in o

102 Heparin provides a potential therapeutic modality, because it not only prevents exten

103 In addition, new therapeutic modalities, both recombinant and plasma deri

104 ill not only improve targeted diagnostic and therapeutic modalities, but may also provide insights in

105 However, the value assigned to a therapeutic modality by the oncology community at large

106 ological explanation so that preventative or therapeutic modalities can be explored.

107 With such a wide variety of therapeutic modalities, clinicians are faced with the ta

108 In ideal scenarios, the drug or therapeutic modality combinations have different mechani

109 Therapeutic modalities consist of identification/withdra

110 However, the currently available therapeutic modalities do not allow for targeted interve

111 uring pregnancy, and a discussion of various therapeutic modalities during pregnancy and lactation.

112 are many new interesting, potentially useful therapeutic modalities emerging in pediatric dermatology

113 erapy (RIT) has finally come of age as a new therapeutic modality, exemplifying the collaboration of

114 therapy, and surgical intervention if other therapeutic modalities fail to prevent progression.

115 terventional strategies showed that existing therapeutic modalities for asthma, such as inhaled corti

116 a molecular framework for the development of therapeutic modalities for both contraception and fertil

117 e tumor cells, provide previously unexplored therapeutic modalities for cancer treatment.

118 ygenase-2 risks, and the potential for novel therapeutic modalities for cardiovascular disease focuse

119 metabolism and may provide the basis for new therapeutic modalities for cardiovascular disease.

120 y of beta-cell function and for enabling new therapeutic modalities for diabetes.

121 on of CXCL10 could aid in the development of therapeutic modalities for HAD.

122 hymocyte globulins could provide ad-ditional therapeutic modalities for immune-mediated disease.

123 synapses could aid in the development of new therapeutic modalities for immunological, neurological,

124 red to combine a wide variety of imaging and therapeutic modalities for improved and personalized can

125 in resistance and suggest new diagnostic and therapeutic modalities for managing the disease.

126 urotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients.

127 seases to develop guidance on diagnostic and therapeutic modalities for NASH.

128 d to identification of new, context-specific therapeutic modalities for precision medicine.

129 the anesthesiologist with current and rising therapeutic modalities for pulmonary disease.

130 These data suggest new therapeutic modalities for resistant hypertension based

131 -theta and indicate V3-based 'decoys' may be therapeutic modalities for T cell-mediated inflammatory

132 is essential for development of efficacious therapeutic modalities for the disease.

133 These findings suggest a number of therapeutic modalities for the treatment and detection o

134 the development of effective dual-targeting therapeutic modalities for the treatment of cancer are t

135 There have been many new developments in therapeutic modalities for the treatment of pediatric de

136 the longer term, generate new diagnostic and therapeutic modalities for treating high-grade malignanc

137 rize current state-of-the-art diagnostic and therapeutic modalities for treatment of AF.

138 n and deep brain stimulation have emerged as therapeutic modalities for treatment refractory depressi

139 EG 10, merits further testing as a potential therapeutic modality for a variety of clinically importa

140 ntation (allo-HCT) is a potentially curative therapeutic modality for ALL, and this review describes

141 pe II receptor (TbetaRII), as an alternative therapeutic modality for blocking TGF-beta signaling in

142 c event, suggesting a previously undescribed therapeutic modality for cerebral ischemia/hypoxia and i

143 ta suggest that Nano-CUR may be an effective therapeutic modality for cervical cancer.

144 ill not enough evidence to support tDCS as a therapeutic modality for depression.

145 uggest that TSC may be a safe and beneficial therapeutic modality for early stroke intervention, irre

146 ficacy and safety of gene-modified HSCs as a therapeutic modality for engineered cancer immunotherapy

147 Hb sequestration by Hp might therefore be a therapeutic modality for enhancing transfusion safety in

148 /Stat inhibitors and demethylating agents as therapeutic modality for human liver cancer.

149 cyst(e)inase represents a safe and effective therapeutic modality for inactivating antioxidant cellul

150 ter who had undergone surgery as their first therapeutic modality for invasive breast cancer from Sep

151 evels of MDMX and may offer a more effective therapeutic modality for MDMX-overexpressing cancers.

152 argeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients.

153 Here, we review the development of RNAi as a therapeutic modality for neurodegenerative diseases affe

154 sidered as an alternative minimally invasive therapeutic modality for patients who are not candidates

155 pment of VSV-mediated virotherapy as a novel therapeutic modality for patients with advanced HCC.

156 otential use of antioxidants as a supportive therapeutic modality for patients with RD.

157 formed to evaluate the effectiveness of this therapeutic modality for patients with sclerotic chronic

158 The blockage of H4R could be a new therapeutic modality for prevention of bone destruction

159 nical trials established ICD as an important therapeutic modality for primary and secondary preventio

160 at PIM1 inhibition might offer an attractive therapeutic modality for prostate cancer, particularly f

161 ed, double-blind multinational trial of this therapeutic modality for ragweed allergy.

162 e adjacent photoreceptors is a promising new therapeutic modality for RPE-related retinal diseases.

163 Thus, PPCA is a therapeutic modality for selective, antigen-specific imm

164 rhBMP-2 represents a potential therapeutic modality for severe peri-implant hard tissue

165 rationale to target the OX40L-OX40 axis as a therapeutic modality for SLE.

166 been employed during the past 30 years as a therapeutic modality for spinal cord injury (SCI) in ani

167 rethral slings continue to be the front-line therapeutic modality for stress urinary incontinence.

168 t omega-3 PUFAs could potentially serve as a therapeutic modality for T1D.

169 conjugates (ADCs), an increasingly important therapeutic modality for targeted cancer treatment, have

170 ease provide a path for using electrons as a therapeutic modality for targeting molecular mechanisms

171 tive ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brai

172 DALK is an effective therapeutic modality for the management of advanced kera

173 GHRH antagonists could offer a new therapeutic modality for the management of advanced NHL.

174 deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of addiction.

175 ide, by inhibition of BACE, is an attractive therapeutic modality for the treatment of Alzheimer's di

176 mmatory cytokine gene expression may offer a therapeutic modality for the treatment of autoimmune dac

177 NLY and suggest that GNLY may prove a useful therapeutic modality for the treatment of cancer.

178 ngly, inhibition of Nox4 may provide a novel therapeutic modality for the treatment of neuropathic pa

179 tation (FMT) has been shown to be a superior therapeutic modality for the treatment of recurrent Clos

180 chemokine pathways may represent a potential therapeutic modality for these lesions.

181 pon TCR signaling may represent an effective therapeutic modality for this class of lethal human canc

182 targeting upregulated Wnt signaling as a new therapeutic modality for this disease.

183 n of the alternative pathway may represent a therapeutic modality for treating acute phases of inflam

184 Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy.

185 RNAi may provide an important new therapeutic modality for treating infection, cancer, neu

186 rate that combination therapy is a promising therapeutic modality for treating NPD and suggest a pote

187 ignaling pathway may represent a significant therapeutic modality for treating synovial sarcoma.

188 r approaches is potentially an effective new therapeutic modality for treating the activated B cell-l

189 expression and activities may provide a new therapeutic modality for treatment of hypoxic tumors.

190 ade of PDK1/PI3K signaling might offer a new therapeutic modality for wild-type PTEN tumors.

191 eby validating this model to test innovative therapeutics modalities for this disease.

192 Lung transplantation is a therapeutic modality frequently used in end-stage lung d

193 that treatment with vismodegib adds a novel therapeutic modality from which patients with advanced b

194 Preclinical development of new therapeutic modalities has been hindered by models with

195 Aside from early surgical resection, no therapeutic modality has been found to afford a high lik

196 However, the application of this therapeutic modality has been impeded by a number of con

197 alysis of protein function, but its use as a therapeutic modality has been limited by inefficient or

198 Minimally invasive therapeutic modalities have become the standard treatmen

199 egy in drug discovery, and a large number of therapeutic modalities have been developed.

200 Common adverse effects of this therapeutic modality have been previously documented.

201 oriented toward defining the most beneficial therapeutic modality have resulted in some well-designed

202 lity in more clinically-relevant imaging and therapeutic modalities, here we have explored the use of

203 ood products, as is keeping abreast of novel therapeutic modalities in a rapidly evolving field.

204 s of antigen-smIg interactions may represent therapeutic modalities in CLL.

205 he advent of a new generation of much-needed therapeutic modalities in leukemia and other cancers.

206 ly diagnosis, and application of appropriate therapeutic modalities in sepsis-induced AKI include lim

207 intestinal inflammation and may suggest new therapeutic modalities in the future.

208 e prognostic markers and will guide improved therapeutic modalities in the future.

209 ight contribute to the development of better therapeutic modalities in the treatment and/or cure of a

210 e neoplasia type 1, and the precise order of therapeutic modalities in the treatment of patients with

211 ing of EPCR may lead to development of novel therapeutic modalities in treating hemophilia, inflammat

212 ough modulation of PPARgamma signaling, as a therapeutic modality in a large proportion of AML patien

213 trategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better und

214 The use of Intacs as a therapeutic modality in contact lens intolerant patients

215 cacy of systemically administered siRNA as a therapeutic modality in experimental pancreatic cancer.

216 we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice.

217 manized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals.

218 ate that CO administration is effective as a therapeutic modality in mice with established chronic co

219 poE in the central nervous system might be a therapeutic modality in neurodegenerative disorders.

220 e the importance of alpha particles as a new therapeutic modality in patients with bone metastatic ca

221 Administration of CO may have potential as a therapeutic modality in patients with ruptured cerebral

222 septic animals and appears to be a promising therapeutic modality in sepsis.

223 Wnt5a as a potential target for an efficient therapeutic modality in severe human diseases as diverse

224 ntial translational utility of DC.Tbets as a therapeutic modality in the cancer setting.

225 g the transformation of RNAi into a powerful therapeutic modality in the clinic.

226 erventions are becoming a safe and effective therapeutic modality in the management of various valvul

227 roteasome inhibition has been validated as a therapeutic modality in the treatment of multiple myelom

228 apy, as well as explores novel and effective therapeutic modalities including antiviral therapy with

229 Numerous diagnostic and therapeutic modalities including endoscopic ultrasound,

230 clinical trial data with currently available therapeutic modalities, including DES and drug-coated ba

231 al evidence for potential new diagnostic and therapeutic modalities, including imaging, biomarkers, p

232 or to introduce a broad range of imaging or therapeutic modalities into a single conduct.

233 following chemotherapy, and developing such therapeutic modalities is a key priority.

234 rs and acquired or innate resistance to this therapeutic modality is a major clinical problem.

235 Messenger RNA as a therapeutic modality is becoming increasingly popular in

236 macogenomics to predict response to oncology therapeutic modalities led to a dramatic increase in the

237 sponses represents a possible small-molecule therapeutic modality (microbiome-biosynthetic gene thera

238 VEGF-independent pathways and that anti-CEP therapeutic modalities might be of value in limiting CNV

239 sary for surgeons and their patients and new therapeutic modalities must continue to be explored.

240 echnology, and translation from discovery to therapeutic modalities of treatment.

241 Radiotherapy, a therapeutic modality of cancer treatment, nonselectively

242 le for using Aurora kinase A inhibition as a therapeutic modality of CTCL.

243 /or NADPH oxidase inhibition may represent a therapeutic modality of diabetic kidney disease.

244 nsion, renalase replacement is an attractive therapeutic modality owing to its role in catecholamine

245 the genetic engineering of T cells is now a therapeutic modality pursued at an increasing number of

246 Many issues in the identification of new therapeutic modalities remain.

247 Combining ALK inhibition with other novel therapeutic modalities should prove even more effective.

248 LT may hold promise for a broadly applicable therapeutic modality specific to mesenchymal lineage tum

249 R dysregulation, then the development of new therapeutic modalities specifically targeting this viral

250 particularly in combination with established therapeutic modalities such as radiation.

251 uction arises from the fact that traditional therapeutic modalities, such as autologous bone grafting

252 different types of immunotherapies and other therapeutic modalities, such as drugs against specific s

253 Despite the reported therapeutic modalities, such as topical and systemic cor

254 Currently used therapeutic modalities (surgery, radiation, and/or chemo

255 lymphatics in CNS disorders and develop new therapeutic modalities targeting these systems.

256 ic agents in patients with acute stroke, are therapeutic modalities that are now widely available, wi

257 There are new therapeutic modalities that help patients with this dise

258 oals and endpoints of management, and latest therapeutic modalities that includes the harnessing of i

259 ution of vasculopathy in SCD and may suggest therapeutic modalities that interrupt heme-mediated infl

260 Therapeutic modalities that target or supplement ganglio

261 intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiati

262 At present, bariatric surgery is the only therapeutic modality that can produce sustained weight l

263 geneic stem cell transplantation is the only therapeutic modality that provides a cure for myelofibro

264 rsistent despite exhaustion of all available therapeutic modalities, then an argument can be made tha

265 based use of anticoagulation, and adjunctive therapeutic modalities (thrombolysis, vena cava interrup

266 Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR protein

267 focused on identifying additional drugs and therapeutic modalities to benefit those individuals refr

268 ansduction may eventually lead to innovative therapeutic modalities to improve the clinical response

269 Present therapeutic modalities to limit the adverse consequences

270 prove useful in evaluating antivirals and/or therapeutic modalities to prevent or inhibit demyelinati

271 At present, therapeutic modalities to prevent or treat AKI are extre

272 vide evidence for TCR-like mAbs as potential therapeutic modalities to target EBV-associated diseases

273 use of FAAH inhibitors may constitute novel therapeutic modalities to treat immune-mediated liver in

274 ancer, thus opening up the potential for new therapeutic modalities to treat these diverse diseases.

275 y after ITx but also demonstrate a potential therapeutic modality to ameliorate its consequences.

276 replacement might be a potentially promising therapeutic modality to attenuate or block negative neur

277 rovides biochemical evidence for a potential therapeutic modality to correct beta-oxidation deficienc

278 a novel strategy that may be promising as a therapeutic modality to eliminate the C481S-mutant BTK c

279 ation and vascular remodeling is a promising therapeutic modality to preserve tissues subject to isch

280 e of HA using Pep-1 could constitute a novel therapeutic modality to prevent IL-2-mediated toxicity,

281 e only identified ligand for CXCR4, as a new therapeutic modality to recruit stem cells to individual

282 restoring mTOR signaling may be an effective therapeutic modality to reduce neuronal cell death in di

283 otherapy has emerged as a potential adjuvant therapeutic modality to reduce the incidence and mortali

284 suggest that elafin could be engineered as a therapeutic modality to treat breast cancer without toxi

285 py is being increasingly recognized as a key therapeutic modality to treat cancer and represents one

286 effects and so may be most appropriate as a therapeutic modality to treat GVHD.

287 and/or enhance innate immune responses as a therapeutic modality to treat respiratory infections.

288 Novel therapeutic modalities under investigation include DNA v

289 implications, and, finally, drugs and other therapeutic modalities used in HF treatment that target

290 ed health-care workers who have expertise in therapeutic modalities used in the treatment of patients

291 al complement complex, and its blockade as a therapeutic modality, was investigated in a mouse model

292 to the poor response of GBM patients to any therapeutic modalities, which include ionizing radiation

293 nd the modulation of microglia activity as a therapeutic modality will be discussed.

294 in using miRNAs as circulating biomarkers or therapeutic modalities, will hopefully be able to provid

295 ration, and tissue remodeling are developing therapeutic modalities with great potential medical valu

296 siRNAs are a new class of therapeutic modalities with promising clinical efficacy

297 ng of the human ribosome is an unprecedented therapeutic modality with a genome-wide selectivity chal

298 n in endothelial cells may represent a novel therapeutic modality with the potential to inhibit infla

299 address the complexities to make such novel therapeutic modalities work in the clinic.

300 uggests that preclinical efficacy testing of therapeutic modalities would be most informative when th