ライフサイエンスコーパス: thyroglobulin

1 s, perhaps by augmenting the antigenicity of thyroglobulin.

2 particularly in patients with elevated serum thyroglobulin.

3 oid peroxidase, sodium iodine symporter, and thyroglobulin.

4 nding to the fucose-containing glycoprotein, thyroglobulin.

5 l surface to catalyze iodination of secreted thyroglobulin.

6 antigen, neu, and an unrelated self-antigen, thyroglobulin.

7 an influence on tyrosine sulfate content of thyroglobulin.

8 bonucleoprotein, four to histone and none to thyroglobulin.

9 ession of MHC class II, and up-regulation of thyroglobulin.

10 gative DTC patients with elevated and rising thyroglobulin.

11 osylation sites in the homologous segment of thyroglobulin.

12 gative DTC patients with elevated and rising thyroglobulin.

13 ive congenital hypothyroidism with deficient thyroglobulin.

14 of recombinant human thyrotropin-stimulated thyroglobulin.

15 ha(1)-acid glycoprotein, immunoglobulin, and thyroglobulin.

16 of the parameters evaluated, including serum thyroglobulin.

17 ung NODCCR7(ko/ko) mice by immunization with thyroglobulin.

18 yoglobin (17 kDa), transferrin (77 kDa), and thyroglobulin (670 kDa) proteins was accomplished in a s

19 In addition, four of 22 tumors co-express thyroglobulin (a non-neuroendocrine follicular epithelia

20 h post-translational processing of wild-type thyroglobulin (a secretory glycoprotein) as well as endo

21 amma also inhibited 4-fold the expression of thyroglobulin, a native cAMP-responsive gene, in primary

22 Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich regions I,

23 er than GRP94 did not detectably differ, and thyroglobulin achieved transport competence in both kind

24 ng the IgG through a series of melibiose and thyroglobulin-agarose columns.

25 Among the 75 patients in whom thyroglobulin analysis was performed, 81% had decreased

26 N-gamma(-/-) donor mice activated with mouse thyroglobulin and anti-IL-2R mAb induced severe granulom

27 carcinoma (DTC) patients with elevated serum thyroglobulin and both negative radioiodine imaging and

28 Preincubation of cells with glycoproteins (thyroglobulin and fetuin), but not simple sugars, blocks

29 a specific combination of polymorphisms for thyroglobulin and HLA-DR markedly increases the odds rat

30 ed splenocytes activated in vitro with mouse thyroglobulin and interleukin (IL)-12.

31 ed splenocytes activated in vitro with mouse thyroglobulin and interleukin-12.

32 n, abolished hormone-regulated expression of thyroglobulin and the sodium/iodide symporter.

33 tion in vivo, CBA/J mice were immunized with thyroglobulin and then injected with IFN-gamma and TNF-a

34 se spontaneously occurring autoantibodies to thyroglobulin and thyroid peroxidase were unaffected.

35 develops in NOD.H2(h4) mice associated with thyroglobulin and thyroid-peroxidase, but not TSHR, Abs.

36 All offspring developed Abs to thyroglobulin and thyroid-peroxidase.

37 the substrate for thyroid hormone synthesis (thyroglobulin) and the ability to recover and retain int

38 t chain did not cleave radiolabeled albumin, thyroglobulin, and annexin V under conditions that readi

39 inent early iodination sites in this part of thyroglobulin, and because the N-terminal region was pre

40 ated with circulating autoantibodies against thyroglobulin, and development of primary hypothyroidism

41 histologic subtype of tumor, levels of serum thyroglobulin, and morphologic findings on full-dose CT

42 storis, hen ovalbumin, bovine fetuin, bovine thyroglobulin, and several invertase preparations from w

43 d spleen cells activated in vitro with mouse thyroglobulin, anti-IL-2R, and IL-12.

44 In long-term follow-up of DTC patients with thyroglobulin antibodies, 96% with undetectable TSHR mRN

45 (e.g., elevated thyroglobulin level without thyroglobulin antibodies, positive results on recent fin

46 globulin concentrations or anti-DNA and anti-thyroglobulin antibodies.

47 of the 652 patients (95%) without detectable thyroglobulin antibodies.

48 ovide an overview of the clinical utility of thyroglobulin antibody (TgAb) measurements in the manage

49 molecular weight complex at the position of thyroglobulin (approximately 670 kDa).

50 and CdtC-II(Ec) bind immobilized fetuin and thyroglobulin as well as fucose and to a lesser degree N

51 of TRA, parathyroid hormone, calcitonin, and thyroglobulin, as part of an effort to better define the

52 of the asialoglycoprotein receptor (ASGP-R), thyroglobulin, asialothyroglobulin, and antibody against

53 iter with defective thyroglobulin, GRP94 and thyroglobulin associate in a protracted fashion.

54 id glands in Mct8-KO mice contained more non-thyroglobulin-associated T4 and triiodothyronine than di

55 is not investigating the standardization of thyroglobulin at the present time.

56 nd inhibited further increases in anti-mouse thyroglobulin autoantibodies when administered to mice t

57 une thyroiditis (SAT) and produce anti-mouse thyroglobulin autoantibodies when they receive 0.05% NaI

58 letion also resulted in increased anti-mouse thyroglobulin autoantibody responses and increased expre

59 nt of SAT, development of SAT and anti-mouse thyroglobulin autoantibody responses were reduced.

60 Tg(+) mice always had reduced anti-mouse thyroglobulin autoantibody responses, compared with Tg(-

61 Most Tg mice produced less anti-mouse thyroglobulin autoantibody than did wild type (WT) mice.

62 yr5, the most important hormonogenic site of thyroglobulin, because Tyr5 and Tyr130 are proximate, be

63 fter thyroidectomy and radioiodine ablation, thyroglobulin becomes a sensitive marker for the presenc

64 or alpha-Gal-containing analytes CTX, bovine thyroglobulin (Bos d TG), and human serum albumin (HSA)-

65 the Engelbreth-Holm-Swarm sarcoma and bovine thyroglobulin, both of which contain multiple Galalpha1,

66 letion did not alter the balance of free vs. thyroglobulin-bound I(-) in the thyroid (distinguished u

67 glands of TSHR-KO mice produced uniodinated thyroglobulin, but the ability to concentrate and organi

68 The same mice were also exposed to mouse thyroglobulin by chronic i.v. injections.

69 stimulates both uptake in and production of thyroglobulin by thyroid cells and the results are compa

70 Thyroglobulin can be measured in either serum or dried b

71 induced diabetes of youth, and misfolding of thyroglobulin can result in autosomal recessive congenit

72 -free survival, safety, and changes in serum thyroglobulin concentration.

73 The serum thyroglobulin concentrations and the prevalence of sympt

74 lysis was performed, 81% had decreased serum thyroglobulin concentrations during treatment, as compar

75 Serum thyroglobulin concentrations increased in 15 of 35 teste

76 Truncated thyroglobulin devoid of the ChEL domain was incompetent

77 nding, we have studied recombinant nonmutant thyroglobulin expressed in control Chinese hamster ovary

78 l lines with DLCs robustly restored hNIS and thyroglobulin expression and iodide uptake capacity.

79 able to prevent, and to reverse, the loss of thyroglobulin expression which occurs normally in TSH-de

80 n of colonies with epithelial morphology and thyroglobulin expression, capable of 10 - 15 population

81 um-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid ho

82 SH-stimulated changes in cell morphology and thyroglobulin expression, while RasG37 had no effect on

83 in humans and rodents; these mutations block thyroglobulin from exiting the ER and induce ER stress.

84 in (NLGN) and associated with autism and the thyroglobulin G2320R (G221R in NLGN) mutation responsibl

85 localized GRINA to band 8q24, distal to the thyroglobulin gene.

86 tiation (for example, thyroid peroxidase and thyroglobulin genes).

87 so expressed the sodium iodide symporter and thyroglobulin genes.

88 congenital hypothyroid goiter with defective thyroglobulin, GRP94 and thyroglobulin associate in a pr

89 as phosphatidylserine, myelin basic protein, thyroglobulin, histone, insulin, cytochrome C, and beta-

90 Three developmental promoters (thyroglobulin, Hox2.6 and Myf5) were then sequentially i

91 elopment of SAT and production of anti-mouse thyroglobulin IgG1 autoantibodies.

92 l activity as a transcriptional regulator of thyroglobulin in 1989, the bulk of the ensuing research

93 oexpression of secretory ChEL with truncated thyroglobulin increased intracellular folding, promoted

94 in mice undergoing TUBO tumor rejection and thyroglobulin injection than in those experiencing eithe

95 However, the thyroid-derived protein thyroglobulin is increasingly being used for this purpos

96 a central intrafollicular compartment, where thyroglobulin is iodinated to form the protein precursor

97 xenoantibodies and reactive with epitopes of thyroglobulin, laminin, and heparan sulfate proteoglycan

98 duce thyroid hormone at the acceptor site in thyroglobulin, leaving dehydroalanine or pyruvate at the

99 94% of hypothyroid patients) and stimulated thyroglobulin less than 2 ng/ml (95%, euthyroid; 96%, hy

100 A negative Thyrogen-stimulated thyroglobulin level has a negative predictive value of u

101 fter ablation and also an undetectable serum thyroglobulin level in the absence of antithyroglobulin

102 unnecessary to repeat a Thyrogen-stimulated thyroglobulin level in the surveillance of patients with

103 al evidence of disease included a suppressed thyroglobulin level of less than 1 ng/mL and a stimulate

104 level of less than 1 ng/mL and a stimulated thyroglobulin level of less than 2 ng/mL, rhTSH-assisted

105 was normal in 652 (95%), and the stimulated thyroglobulin level was 1.0 ng per milliliter or less in

106 f having metastasis from DTC (e.g., elevated thyroglobulin level without thyroglobulin antibodies, po

107 nagement of selected cases regardless of the thyroglobulin level.

108 disease; all patients had decreases in serum thyroglobulin levels (mean reduction, 89%).

109 recurrent or metastatic disease with rising thyroglobulin levels (n = 39).

110 ultrasound, I whole body scan, and/or serum thyroglobulin levels for recurrence at the treatment sit

111 ient group and for those patients with serum thyroglobulin levels of less than 5, 5-10, and more than

112 The sensitivities of 18F-FDG PET/CT at serum thyroglobulin levels of less than 5, 5-10, and more than

113 ation, 61 consecutive patients with elevated thyroglobulin levels or a clinical suspicion of recurren

114 Thyroglobulin levels tended to be higher in patients wit

115 w improved understanding of the use of serum thyroglobulin levels to predict future risk of recurrenc

116 venteen (95%) of 19 patients for whom serial thyroglobulin levels were available showed a marked and

117 Serum thyroglobulin levels were concurrently determined by rad

118 ilable showed a marked and rapid response in thyroglobulin levels with a mean decrease of 70%.

119 both negative 131I WBS findings and elevated thyroglobulin levels.

120 operative findings, pathology, imaging, and thyroglobulin levels.

121 e-stranded and double-stranded DNA, insulin, thyroglobulin, LPS, influenza virus, and Borrelia burgdo

122 ration of region I is a limiting step in the thyroglobulin maturation process, and this step is facil

123 Thyroglobulin may prove to be a useful biomarker for bot

124 ed strategies rely primarily on serial serum thyroglobulin measurements combined with cervical ultras

125 catalytic (esterases) and the noncatalytic (thyroglobulin) members of the esterase/lipase family of

126 mice permit thyroiditis induction with mouse thyroglobulin (mTg) after depleting regulatory T cells (

127 Spleen cells from mouse thyroglobulin (MTg) and LPS-primed IL-4(+/+) and IL-4(-/

128 autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies, the levels of which

129 y T and B cells and production of anti-mouse thyroglobulin (MTg) autoantibody.

130 They produced little anti-mouse thyroglobulin (MTg) IgG1, but had levels of anti-MTg IgG

131 Relative to mouse thyroglobulin (mTg) immunized controls, mTg-immunized mi

132 responses to human ErbB-2 (Her-2) and mouse thyroglobulin (mTg) were tested in transgenic mice expre

133 Recipients of mouse thyroglobulin (MTg)-primed spleen cells activated in the

134 mice with autoimmune thyroiditis using mouse thyroglobulin (mTg)-pulsed anti-CTLA-4 agonistic Ab-coat

135 athological features can be induced by mouse thyroglobulin (MTg)-sensitized spleen cells activated in

136 regulatory T cells that could suppress mouse thyroglobulin (mTg)-specific T cell responses in vitro,

137 rat erbB-2 (neu) and another self Ag, mouse thyroglobulin (mTg).

138 Since thyroglobulin, no new blood tests for differentiated thy

139 Both proinsulin and thyroglobulin normally form homodimers; the mutant versi

140 patient sera with FcepsilonRIalpha, but not thyroglobulin or thyroid peroxidase, resulted in the dec

141 presence of antibodies to thyroperoxidase or thyroglobulin, or thyroid-stimulating hormone receptor a

142 , cepharanthine blocked T-cell activation by thyroglobulin peptides, in particular Tg.2098 in mice th

143 expressed in Abs formed on immunization with thyroglobulin, pneumococcal polysaccharide, and ssDNA-me

144 as used to then identify its location in the thyroglobulin polypeptide chain.

145 Patients who are thyroglobulin-positive but radioiodine-negative or who h

146 hat further assessment of 131I WBS-negative, thyroglobulin-positive patients by 18F-FDG PET/CT may ai

147 Thyroglobulin (precursor for thyroid hormone synthesis)

148 t not O-linked carbohydrates from fetuin and thyroglobulin prevents binding of CdtA-II(Ec) and CdtC-I

149 at transgenic mice expressing CCL21 from the thyroglobulin promoter (TGCCL21 mice) have significant l

150 irus serotype 8 (AAV8) with a liver-specific thyroglobulin promoter was used to stably express human

151 ice expressing TGF-beta under control of the thyroglobulin promoter were generated to assess the role

152 e (HSVI-TK) is driven in thyrocytes from the thyroglobulin promoter, the drug Ganciclovir causes the

153 e of CD97, we produced a transgenic model of thyroglobulin promoter-driven CD97 expression.

154 cells of transgenic FVB/N mice with a bovine thyroglobulin promoter.

155 expression of IFN-alpha under control of the thyroglobulin promoter.

156 DIT was coupled to porcine thyroglobulin (PTg) with a molar ratio of 205:1.

157 tions in the ChEL domain impaired folding of thyroglobulin region I-II-III.

158 Secretion of mature thyroglobulin requires extensive folding and glycosylati

159 , and 0.9980 for myoglobin, transferrin, and thyroglobulin, respectively, were obtained.

160 ere obtained for myoglobin, transferrin, and thyroglobulin, respectively.

161 protein product bound to IGFBP-2 through the thyroglobulin-RGD region of the C terminus of IGFBP-2.

162 DR3 by separately treating 20 purified human thyroglobulin samples with cathepsins B, D, or L, lysoso

163 ctions between regions that are required for thyroglobulin secretion.

164 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized spleen cells activated in vitro

165 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized splenocytes activated in vitro

166 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized splenocytes activated in vitro

167 n of an alpha-Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response.

168 ression of the thyroid-specific target genes thyroglobulin, sodium iodide symporter, thyroperoxidase,

169 These mice produced thyroglobulin-specific antibody and IFN-gamma-secreting

170 mma(-/-) mice produced lower levels of mouse thyroglobulin-specific autoantibodies after immunization

171 roid slices, isolated and iodinated the [14C]thyroglobulin (Tg I), separated its N-terminal approxima

172 Nonlabeled thyroglobulin (Tg II) was isolated from the same glands

173 cal synergism between amino acid variants in thyroglobulin (Tg) and specific HLA-DR3 pocket sequence

174 in 2 known overlapping protein-coding genes, thyroglobulin (TG) and Src-like adaptor (SLA).

175 unction (as shown by increased expression of thyroglobulin (Tg) and the sodium/iodide symporter).

176 Autoantibodies to thyroglobulin (Tg) are a prominent feature of the two au

177 ans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene.

178 dal T4 production results from iodination of thyroglobulin (TG) at residues Tyr(5) and Tyr(130), wher

179 quantifying three forms of unlabeled, human thyroglobulin (Tg) by bottom-up protein analysis.

180 Follicular thyroglobulin (TG) decreases expression of the thyroid-r

181 In vertebrates, the thyroglobulin (Tg) gene product must be exported to the

182 The 8q24 locus, which contains the thyroglobulin (Tg) gene, was previously shown to be stro

183 erminal cholinesterase-like (ChEL) domain of thyroglobulin (Tg) has been identified as critically imp

184 t factor by binding to the secretory protein thyroglobulin (Tg) in the ER, thereby facilitating its s

185 tric lipase (LIPF) in stomach carcinoma, and thyroglobulin (TG) in thyroid carcinoma.

186 We recently showed that thyroglobulin (Tg) is a heparin-binding protein and that

187 When thyroglobulin (Tg) is endocytosed by thyrocytes and tran

188 Thyroglobulin (Tg) is the macromolecular precursor of th

189 ted thyroid carcinoma, based on an increased thyroglobulin (Tg) level and negative neck ultrasound (U

190 Serum thyroglobulin (Tg) levels were measured while patients w

191 We also identified 5 thyroglobulin (Tg) peptides that bound to DRbeta1-Arg74.

192 Follicular thyroglobulin (TG) selectively suppresses the expression

193 tudy, we show that the previously identified thyroglobulin (Tg) T cell epitope p2549-2560 containing

194 n the apical surface of thyroid cells, binds thyroglobulin (Tg) with high affinity in solid phase ass

195 f secretory proteins, we studied the fate of thyroglobulin (Tg), a large oligomeric secretory glycopr

196 n reflection mode for the detection of human Thyroglobulin (TG), a protein marker of differentiated t

197 thyrocytes, GRP94 interacts transiently with thyroglobulin (Tg), and in thyrocytes of animals sufferi

198 permits disease induction with heterologous thyroglobulin (Tg), but unlike conventional susceptible

199 cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porp

200 ance, the thyroid hormone precursor protein, thyroglobulin (Tg), has been experimentally investigated

201 iditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic con

202 Moreover, it is inducible with thyroglobulin (Tg), the common autoantigen in either spe

203 Thyroglobulin (Tg), the major protein secreted by thyroi

204 Newly synthesized thyroglobulin (Tg), the major secretory glycoprotein of

205 Thyroglobulin (TG), the primary synthetic product of the

206 Newly synthesized thyroglobulin (Tg), the secretory glycoprotein that serv

207 Thyroglobulin (Tg), the thyroid hormone precursor, is a

208 Newly synthesized thyroglobulin (Tg), the thyroid prohormone, forms detect

209 Detection of mRNA transcripts for thyroglobulin (TG), thyroid peroxidase (TPO) and RET/PTC

210 Polyreactive and thyroglobulin (Tg)-directed proteolytic activities prese

211 nts included response correlation with serum thyroglobulin (Tg); functional imaging; tumor genotype;

212 Secretion of thyroglobulin (Tg, a large homodimeric glycoprotein) is

213 Thyroglobulin (Tg, precursor for thyroid hormone synthes

214 In humans, deficient thyroglobulin (Tg, the thyroid prohormone) is an importa

215 FT3], thyroid-stimulating hormone [TSH], and thyroglobulin [Tg]) and levels of Pb, Hg, and Cd in bloo

216 pression of thyroid differentiation markers, thyroglobulin, thyroid-stimulating hormone receptor, thy

217 SH and the agonists increase mRNA levels for thyroglobulin, thyroperoxidase, sodium iodide symporter,

218 ained significantly lower levels of AIRE and thyroglobulin, to which tolerance is typically lost in a

219 ction including thyroid-stimulating hormone, thyroglobulin, total and free thyroxine, and total and f

220 Upon immunization with murine thyroglobulin, transgenic mice developed milder disease

221 by expression of cytokeratin 18, E-cadherin, thyroglobulin, TTF-1 and Pax-8 proteins.

222 domain (GA733 type 1 motif), a cysteine-rich thyroglobulin type 1A domain (GA733 type 2 motif), and a

223 recently determined disulfide pattern of the thyroglobulin type 1A domain of insulin-like growth fact

224 ing hormone (TSH), free thyroxine (FT4), and thyroglobulin, vary widely due to variability in the com

225 amined for BRAF and RAS mutations, and serum thyroglobulin was measured at baseline and at each visit

226 ccal vaccines; and autoantibodies to DNA and thyroglobulin were assessed before and after supplementa

227 The immune responses to neu or thyroglobulin were greater in mice undergoing TUBO tumor

228 lum-associated protein degradation of mutant thyroglobulin, whereas degradation of a nonglycosylated

229 ons (thyroid extract, desiccated thyroid, or thyroglobulin), which contain both thyroxine (T4) and tr

230 timulated secretion of the secretory protein thyroglobulin with an efficiency similar to that of wild

231 60 fullerene derivative conjugated to bovine thyroglobulin yielded a population of fullerene-specific